See the mirror

A link between brain damage and religious fundamentalism has now been established by scientists

Just to be clear:   Frontal lobe suppression is a result of infection and illness.   It's part of the immune response and does not necessarily cause brain damage.
Frontal lobe impairment results in increased anxiety and less neural bandwidth to think with. 
You literally get a hyperactive one-track mind.

Religiosity is only one form of obsession.
I have known men with more basic obsessions.
Mine has always taken the form of compulsive medical research.

Yeah, I am now at the point where my frontal lobe dysfunction makes me obsess about frontal lobe dysfunction...


via GIPHY

Next year will be better

Ending the year with an appropriately ironic twist-
A broken lower molar I cannot feel.  Of course...

Hopefully when I get it fixed, my verbal tics will finally cease.
It is the one symptom I have that has not resolved after all my efforts.
I have been blurting and spasming uncontrollably for months.

This connection between pain insensitivity and mental problems is getting so frakking annoying...

Okay I'll Play

So this is what I did for the past decade:

-I survived.
-I found what I was looking for.

Right under my nose.

Go figure.

Squad Goals

I have always hated Miss America.
This one rocks a lab coat.


‘Miss America can be a scientist’: Camille Schrier of Virginia wins after onstage chemistry experiment.

So much onion dust in this kitchen...

EFFIN AY!!! HERE IT IS!!!!!

Effects of Very Low Calorie Ketogenic Diet on the Orexinergic System

Orexin-A levels significantly increased after dietary treatment.

Grazie Italia!

Article Roundup

Science underestimated dangerous effects of sleep deprivation

Chronic ketamine abuse is associated with orexin-A reduction

Greatly increased number of detected hypocretin cells in human heroin addicts

Reduced plasma orexin-A levels in patients with bipolar disorder.


Association of pharyngitis with oral antibiotic use for the treatment of acne

High resistance against clindamycin, metronidazole and amoxicillin in Porphyromonas gingivalis isolates of periodontal disease

Antimicrobial resistance is drastically rising

Green tea could hold the key to reducing antibiotic resistance

Antibiotic usage associated with increased risk of rheumatoid arthritis

Antibiotics Before Dental Visit Can Be Harmful

Antibiotics weaken flu defenses in the lungs
Antibiotics can leave the lung vulnerable to flu viruses, leading to significantly worse infections and symptoms



Ketogenic diet helps tame flu virus

Flu virus' best friend: Low humidity

This Inexpensive Action Lowers Hospital Infections And Protects Against Flu Season
Raise the humidity...    

A bad bout of flu triggers 'taste bud cells' to grow in the lungs ...
A severe case of the flu can actually reshape the architecture of their lungs and forever compromise their respiratory function.
(odd personal observation- this sounds exactly like what asthma felt like, fuzzy lungs)

Cells That ‘Taste’ Danger Set Off Immune Responses


Aspirin may halve air pollution harms

Washing Machines May Sometimes Harbor Drug-Resistant Bacteria,
Try adding baking soda to your laundry after illnesses.

Omega-3 fatty acids' health benefit linked to stem cell control

What tattoos really do to our bodies' immune systems

Groundbreaking New Study Sheds Doubt on Many Heart Procedures
The new research study shows drugs and a healthier lifestyle can be as effective as many heart procedures for patients with stable coronary artery disease.

Man’s body brews its own beer after yeast take over his gut microbiome

Want to Take Better Notes? Ditch the Laptop for a Pen and Paper
New research might have you reconsidering that old school pen and paper if you want to remember more of your notes.

'Mental rigidity' at root of intense political partisanship on both left and right

Did a common childhood illness take down the Neanderthals?
The authors believe the path to extinction may well have been the most common and innocuous of childhood illnesses - chronic ear infections.

The Body’s Clock Offers a Rhythmic Target to Viruses
Viruses and other parasites may sync with their host’s biological clock — or reset it — to gain an advantage.

Happy Immigrant Gratitude Day

 
Last month, for the first time since records began, the number of refugees resettled in the US hit zero.

Holiday Shopping

Dietary zinc protects against Streptococcus pneumoniae infection

Good zinc info here.

State of the Insanity

The big bag of endotoxin has unleashed his berserker brigade.   Fuckin Hooray.

President pardons service members in high profile war crimes cases

“Nine members of his platoon testified against Clint Lorance at his trial. Together, they described a man who arrived in Afghanistan determined to get his hands bloody... not a single soldier from Lorance’s platoon testified on his behalf.”

Buckle up.  Hold the Door.
Winter is Coming.

Endotoxic Masculinity

Trump says Rep. Adam Schiff has a "little 10-inch neck." He then performs this exchange: "What size shirts do you need, Adam?" "I wear a size 9." Returning to his own voice, he says, "Nine! He will not make the LSU football team."

Ha.  Slim, taut necks are a sign of great nasal and oropharyngeal health.  
Schiff is also a competitive runner.

Trump's acute neck inflammation and morbid obesity is suffocating him.
He can barely walk or talk.

A couple more

Well, it looks like Porphyromonas gingivalis is also associated with-

Oral Cancer-  it promotes the proliferation of immortal epithelial cells.
 (which I believe can travel to the lungs and breasts)


Prostate Cancer- yeah, all the old men I know have that.

Ankylosing spondylitis - a rare type of arthritis that affects the spine


here's another plug for Cleure Toothpaste.  Everyone I know is getting it for a gift this year.

Better Insomnia Advice

        Up all night. Sleep all day. Bitchy all the time.

Personally, I like insomnia. I get stuff done at night.

But I'm not normal, so I have thought about this a lot and come to the conclusion that it's pretty much this simple:

It's not that we can't sleep, we prove we can all day long. We just have major problems when we lie down.

It's simply easier for us to sleep upright in a chair.   At work, or school, or while driving...

We make a lot of mucous and it gets in our sinuses and throats and lungs.

When we lie down, all that goop shifts into positions that restrict our breathing.

When our oxygen level is restricted, our brain stems panic and we are supposed to wake up.

Unfortunately, when we are really sick we do not wake up when sleeping in positions that are not conducive to breathing.  We just sleep fitfully instead.

(This manifested as sleepwalking when I was a child.  About thirty minutes after I was put to bed, I would scream-walk to the couch and pass out sitting next to my mother.  Freudians had a grand old time with that symptom.)

You will not get better if you can't breathe or sleep properly.

So first order of business is clean out your snot before bed.

Then get over the idea that you need to lie down flat to sleep.   It's a fallacy perpetuated by mattress companies to get you to buy more expensive beds that still cause poor sleep.

Sleep on an incline. Your head should be higher than your lungs, and your lungs higher than your hips.  This facilitates cranial drainage and movement of the diaphragm. I just use pillows, not a wedge. There are more positional options that way.

If you're really snotty, you have to sleep with your head on it's side. This allows the top sinus to drain, allowing you to relax somewhat.

Get a super squishy pillow that you can shape to prop your head in the right position, and to put gentle pressure on any problematic facial nerves.

When you're really sick, you should sleep almost sitting up. Don't worry what your spouse or roommates think.

Recliner chairs should probably be prescribed instead of cpap.

Your teeth and gums will keep you awake too.

If you are clenching or grinding, or sleep with your hands touching your cheeks- try soothing your mouth.

I have found a teaspoon of olive oil taken orally before bed works wonders.
It seems to lubricate my mouth and throat and help me breathe and swallow and relaxes my head, and before I know it, it's morning.  If you cannot stand to swallow it, swish and spit it out instead.
I keep a small squirt bottle on my nightstand-  I find that I will not get out of bed when my head is clenched, even if I cannot sleep.   But I can reach out one arm...

If that doesn't work, you can try Chloroseptic spray on your gums, or Anbesol on any suspicious teeth.

(But if that works, you need to visit a dentist.)

Shoulders -

A lot of our pathology affects the neck and thus the shoulder nerves. Make sure you have proper pillows and positioning so your neck and arms are comfortable. If you're on your side, prop up the upper arm so your ribs can expand.

Back- 

Our intestinal problems mostly manifest as lower back pain. You're probably constipated and need to check your diet.

Skin-

Dehydration activates the stress response. This is why bathing helps too.

In any case, while you are lying there trying to sleep, think about this... it's the most memorable thing I learned in a decade of research, and I spent a lot of time observing the phenomenon while getting better.

See the Pathology

He's a very sick and twisted man.
Who was put into office by adults who behave like children- just like him.

See the Porphyromonas Gingivalis

The uppers are gone, that's a denture up there.

Update:  heh.
‏Verified account @andylassner Sep 20

Big teaching moment in the Lassner household. Making my kids watch last night’s Rudy Giuliani interview to show them what can happen when you let your teeth rot and it seeps into your brain.

Worse Than Narcolepsy

So much worse.

Cheap and Cruel

Malevolence exacerbated by incompetence.

An attorney "met one 16-year-old mother whose 8-month-old baby was sick with the flu and forced to sleep outside for four days... The mother said the guards took the clothing off the baby’s back, leaving her in a diaper, and forced them to sleep on concrete without a blanket."

A completely preventable infectious and immunological nightmare.
Because of this, I will never forgive any woman who voted for Trump.

Please donate to one of these organizations.

One for the Freudians

Don't EVER call us Hysterical again, you self-serving asshats...

Further Adventures in Pain Insensistivity

Porphyromonas gingivalis is a gram negative bacteria.  The endotoxin in the cell wall of P gingivalis REDUCES PAIN SENSATION, so you don't know it's there.
Your first clue is when you can't remember things.

Go effin figure.

Zombie Shopping List

I use almost all of these products on a regular basis, because I have found they reduce my mouth problems and cognitive weirdness.
Y'all seem to like Chile Chocolate, I am partial to cream cheese with taco sauce.

Go Figure.

These are things that are known to inhibit Porphyromonas gingivalis, which causes gingivitis.

P. gingivalis is the most probable cause of  Alzheimer's Disease. 

Please do not use antibiotics or hydrogen peroxide.   They disrupt the entire microbial balance in your mouth.

===========================

BAKING SODA

A four-week clinical study to evaluate and compare the effectiveness of a baking soda dentifrice and an antimicrobial dentifrice in reducing plaque.
The results of this study indicate that the baking soda dentifrice was more effective than the non-baking soda, antimicrobial dentifrice in plaque removal after a single tooth brushing, and in maintaining significantly lower plaque levels during a four-week period of twice daily, unsupervised tooth brushing.

GREEN/WHITE TEA
Suppresses P. gingivalis and helps your gums resist it too.

Antibacterial, antiadherence, antiprotease, and anti-inflammatory activities of various tea extracts: potential benefits for periodontal diseases.
Extracts from green tea, white tea, oolong tea, and black tea show promise for controlling periodontal disease by their capacity to interfere with P. gingivalis growth and virulence properties, host destructive enzymes, and inflammatory mediator secretion.

Green tea polyphenols enhance gingival keratinocyte integrity and protect against invasion by Porphyromonas gingivalis
These deleterious effects mediated by P. gingivalis were abolished by the green tea extract and EGCG. This protection may be in part related to the ability of tea catechins to inhibit the protease activities of P. gingivalis.

RED WINE

Both resveratrol and low concentration alcohol inhibit P. gingivalis

Resveratrol inhibits Porphyromonas gingivalis lipopolysaccharide-induced endothelial adhesion molecule expression

MILK/CHEESE
Lactoferrin and k-Casein in milk and cheese are preventative too.

Lactoferrin inhibits Porphyromonas gingivalis proteinases and has sustained biofilm inhibitory activity.

Porphyromonas gingivalis Cysteine Proteinase Inhibition by κ-Casein Peptides

LACTOBACILLUS
A probiotic bacteria available at the Health food store. Mostly available in multiple species pills.
Look for this strain on the label: L. Rhamnosus.  It helps me a lot.

Lactobacillus rhamnosus could inhibit Porphyromonas gingivalis biofilm formation

The immunomodulatory probiotic strain L. rhamnosus ATCC 9595 is proposed to be essential for maintaining healthy tissue, with multiple roles including co-aggregation, adhesion, and priming immune responses to ensure rapid and efficient defense against P. gingivalis.

DARK CHOCOLATE
Clinical and biochemical effects of dark chocolate in moderate chronic periodontitis
Consuming dark chocolate could decrease lipid peroxidation, gingival bleeding and inflammation.

FISH OIL/VITAMIN D
I think you have to use the real deal and put the liquid in your mouth.  I use drops in my coffee.

Omega-3 fatty acid reduces Porphyromonas gingivalis-induced experimental periodontal disease in rats.

CAPSAICIN (Chile spice)
Capsaicin inhibits Porphyromonas gingivalis growth and biofilm formation

CURCUMIN
Curcumin is a bright yellow chemical produced by turmeric, a member of the ginger family. It is sold as an herbal supplement. I have good reports on this one, but haven't tried it yet.

Novel therapeutic approach for the treatment of periodontitis by curcumin.

CRANBERRY
I have never tried this.  I think there are extracts available.

Inhibitory effect of cranberry polyphenol on biofilm formation and cysteine proteases of Porphyromonas gingivalis.

A KETOGENIC DIET HELPS TOO
Enhancement of Wound Healing with Dietary Ketosis

If you must eat carbs, Rice has anti-gingivalis activity and sticks to your teeth less than other grains.

METFORMIN
A diabetes drug.  Tightens epithelium.  If you are taking this, stay on it.

STATINS
Atherosclerosis is also associated with P. gingivalis.  Cardiac plaque is probably the same as dental plaque (a theory proposed by Leonardo DaVinci.  Seriously.)

Effects of statins on multispecies oral biofilm identify simvastatin as a drug candidate targeting Porphyromonas gingivalis.
All four tested statins efficiently inhibited P. gingivalis growth and significantly decreased the cumulative bacterial load in developing and established biofilms. Simvastatin was most efficient and decreased P. gingivalis counts more than 1,300-fold relative to the control.

I'm gonna get me some of that.

NICOTINE
Tightens up your epithelium, so your gums bleed less.
But the tars and particles from cigarettes destroy the tissues in other ways.
You should use gum or vapes, and try to quit later when your mouth has healed.

For the record, my dentists never brought up gum disease in my entire life.
Much less offered me non drug options to prevent it.   I learned all this on my own.
Surgery is how they make money.
They were perfectly happy to ignore everything until I needed teeth extracted.

Yo Dr. Mignot

Fuck You, Motherfucker.
We told you over a decade ago it was gastrointestinal.
See the Fucking Vortex.

Lipopolysaccharide Challenge Reduces Orexin Production

Lipopolysaccharide (LPS) is a microbial toxin, produced during gram-negative bacterial infection.
Injecting animals with LPS reduces Orexin production, just like an infection.

**New Research** Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier 

Low orexin levels allow LPS from your microbiome to leak through your intestine into the bloodstream (endotoxemia),  which causes even more orexin dysfunction.  (!!!!!)

Hypocretin/orexin loss changes the hypothalamic immune response

The hypothalmic response to LPS challenge in orexin deficient animals is to cease orexin production altogether.

Effects of inflammation produced by chronic lipopolysaccharide administration on the survival of hypocretin neurons and sleep.

Long term endotoxemia kills orexin cells.

Three Strikes and You're OUT

Infection with the influenza virus causes massive lung damage, raising endotoxin levels drastically, which lowers orexin levels.
Endotoxin reduces the immune response to many bacterial infection, so those are common afterwards.

Strep and staph bacteria then give you another big dose of endotoxin by causing open lesions.

And then the antibiotics they give you burst the bacteria and release A LOT more endotoxin, which shuts down your orexin production completely.

Low levels of orexin impairs healing and promotes intestinal permeability which allows all that endotoxin to leak into your bloodstream constantly,  finally killing the orexin cells.

THIS IS WHY

Because my mother and my doctors regularly dosed me with beta lactam antibiotics when I was a child.

Then they proceeded to tell me I was a stupid, lazy, ungrateful human when I got fat and tired and weepy.
And to just "Snap Out of It"...
And to just eat more frakking fruits and vegetables...

No, I'm not asleep

Please-  If any of you know people on Suvorexant, beg them to discontinue using it.
If they have bad teeth or get an infection, they may end up in the vortex too.

Links I forgot about

The crippling thing about growing up poor that stays with you forever
Terrible diets cause dysfunctional glucose regulation.

The woman who can smell Parkinson's disease
more evidence for my hypothesis that this is a respiratory fungal infection.

The Five Stages of Decay Cupcake

What If Global Warming Were Global Cooling?

Study finds natural selection favors cheaters

People with schizophrenia experience emotion differently from others, 'body maps' show

How a Little Known Native-American Tribe Is Leading the Way to Better Dental Care in America

What makes humans unique among animals
Dolphins have cultural transmission; many animals learn. But only humans teach

Military Doctors Told Them It Was Just "Female Problems."

School shooters usually show these signs of distress long before they open fire
Our analysis found that about 80 percent of mass school shooters were suicidal, based on records we have gathered thus far. This includes the Parkland shooter. Almost all of them die at the scene of the shooting, often by their own hand.

The parking lot suicides
Veterans are taking their own lives on VA hospital campuses, a desperate form of protest against a system that they feel hasn’t helped them.

Negative mood signals body's immune response

Oropharygeal Adjacent Articles

Men with Beards shed a lot of pathogenic bacteria
I have been wondering about that for a long time.

Artificial intelligence can diagnose PTSD by analyzing voices
I'm guessing it's microbial biofilm related nerve dysfunction...

The history of humanity in your face

The Truth About Dentistry
It’s much less scientific—and more prone to gratuitous procedures—than you may think.

Why I do not Pray

Because I have lived a lifetime proving that prayer has absolutely no effect on endotoxin.

RIP  Rachel Held Evans.

For some reason I have been reminded of this old joke a lot lately

One day the different parts of the body were having an argument to see which should be in charge.
The brain said, “I do all the thinking so I’m the most important and I should be in charge.”
The eyes said, “I see everything and let the rest of you know where we are, so I’m the most important and I should be in charge.”
The hands said, “Without me we wouldn’t be able to pick anything up or move anything. So I’m the most important and I should be in charge.”
The stomach said, “I turn the food we eat into energy for the rest of you. Without me, we’d starve. So I’m the most important and I should be in charge.”
The legs said, “Without me we wouldn’t be able to move anywhere. So I’m the most important and I should be in charge.”
Then the rectum said, “I think I should be in charge.”
All the rest of the parts said, “You?!? You don’t do anything! You’re not important! You can’t be in charge.”
So the rectum closed up.
After a few days, the legs were all wobbly, the stomach was all queasy, the hands were all shaky, the eyes were all watery, and the brain was all cloudy. They all agreed that they couldn’t take any more of this and agreed to put the Asshole in charge.

Uh Huh

A four-week clinical study to evaluate and compare the effectiveness of a baking soda dentifrice and an antimicrobial dentifrice in reducing plaque.

The results of this study indicate that the baking soda dentifrice was more effective than the non-baking soda, antimicrobial dentifrice in plaque removal after a single tooth brushing, and in maintaining significantly lower plaque levels during a four-week period of twice daily, unsupervised tooth brushing.

Enhancement of plaque removal efficacy by tooth brushing with baking soda dentifrices: results of five clinical studies.

The collective results from the five controlled clinical studies on over 270 subjects reported in this paper, consistently demonstrate that Arm & Hammer baking soda dentifrices enhanced plaque removal effectiveness of tooth brushing to a significantly greater extent than the non-baking soda dentifrice products.

Bonus:   Green/White Tea suppresses P.gingivalis and helps your gums resist it too.

Constant Ticcing

I am having a real hard time thinking about this.
I have been telling my doctors and dentists my brain problems come from my effin teeth for a decade.
They have rolled their eyes at me.
And taken my money anyway.

The only reason I am alive is because I didn't listen to them.

I can't look at much research because I am tired of screaming right now.
I am very exhausted from living in this mirror.

Anyway, here's the one search I could manage.

Orthodontic brackets increase levels of porphyromonas gingivalis.
(and the tissue wounds that transfer bacteria to the brain...)

Yeah, I had braces for nine years before I was 21.


I'm pretty sure that living in an Alzheimer's facility, eating pancakes, and not remembering to brush your teeth does the same thing...

Tic Tic Tic Tic Tic

We may finally know what causes Alzheimer’s – and how to stop it

Multiple teams have been researching Porphyromonas gingivalis, the main bacterium involved in gum disease, which is a known risk factor for Alzheimer’s. So far, teams have found that P. gingivalis invades and inflames brain regions affected by Alzheimer’s; that gum infections can worsen symptoms in mice genetically engineered to have Alzheimer’s; and that it can cause Alzheimer’s-like brain inflammation, neural damage and amyloid plaques in healthy mice.

“When science converges from multiple independent laboratories like this, it is very compelling,” says Casey Lynch of Cortexyme, a pharmaceutical firm in San Francisco.

Now researchers from Cortexyme and several universities have reported finding the two toxic enzymes that P. gingivalis uses to feed on human tissue in 99 and 96 per cent of 54 human Alzheimer’s brain samples taken from the hippocampus – a brain area important for memory (Science Advances, doi.org/gftvdt). These protein-degrading enzymes are called gingipains, and they were found in higher levels in brain tissue that also had more tau fragments and thus more cognitive decline.

The team also found genetic material from P. gingivalis in the cerebral cortex – a region involved in conceptual thinking – in all three Alzheimer’s brains they looked for it in.

“This is the first report showing P. gingivalis DNA in human brains, and the associated gingipains co-localising with plaques,” says Sim Singhrao at the University of Central Lancashire, UK, who wasn’t involved in the study. Her team has previously found that P. gingivalis actively invades the brains of mice with gum infections.

Everywhere. Always.

Endotoxic Masculinity