Friday, January 26, 2018

Correlation Games

The Startling Link Between Sugar and Alzheimer's
A high-carb diet, and the attendant high blood sugar, are associated with cognitive decline.

Healthy mitochondria could stop Alzheimer's


Hmmmm.   What could possibly affect sugar metabolism and mitochondrial function?
Chronic immune response to bacterial infection and the antibiotics used to treat them...

Boss Baby

One of the more notable recurring bits in the ongoing shitshow:
The Predator in Chief doesn't actually have the balls to say "You're Fired!".

He demands that one of his employees to do the dirty deed.   Every time.

Wednesday, January 17, 2018

For the Record

I passed the cognitive test he took too.
It was pretty freakin simple.
It clearly means nothing.  I'm totally mentally unfit to be the president.

Tuesday, January 16, 2018

The Golden Ticket

McCarthy had one of his staff buy Starbursts and pick out the red and pink ones, which were placed in a jar bearing the name of the majority leader on the side and delivered to the president. A White House official told The Washington Post that Trump was grinning upon receipt of the gift.

These people understand his pathology.   Have found his Pavlovian trigger.
He's a dry drunk.   Alters his mind and poisons his liver with fructose instead.

Sunday, January 14, 2018

Just Saying

If I'm gonna be incinerated, I would like enough warning time to cook a pot of pasta first.
I want to die with the taste of penne with cream and parmesan in my brainstem.

Saturday, January 13, 2018

So glad to be alive today

Glad there were no missile attacks. Glad the internet is still available.  Because I waited my entire life to read this-


Newborn immune activation may have long-term negative impact on brain function
McLean Hospital neuroscientists have found that even a brief episode of immune system activation within days of birth can cause persistent changes in sleep patterns concurrent with increases in epilepsy-like brain activity -- a combination of symptoms common in autism spectrum disorder (ASD) and other developmental conditions. The detailed findings are available in the January 12, 2018, issue of Neuropsychopharmacology."A growing body of evidence suggests that immune system activation, such as that caused by bacterial and viral infections, can play important roles in many brain disorders," explained William Carlezon, PhD, chief of the Division of Basic Neuroscience at McLean Hospital, and senior author of the paper. "While previous research in laboratory animals has established that immune activation during critical prenatal (before birth) developmental periods can later produce the core features of ASD, including decreased social interaction, aberrant communication, and increased repetitive behavior, we wanted to evaluate whether postnatal (during infancy) immune activation could also produce other symptom clusters that are often seen in ASD and related conditions."
In humans, ASD is also frequently associated with certain co-occurring medical conditions, such as sleep disorders and seizures. To determine whether early postnatal immune system activation can produce these types of effects, McLean researchers treated mice with a lipopolysaccharide (LPS), a chemical that simulates a bacterial infection and causes a temporary (1-3 day) activation of the immune system. The LPS was given at a time point in mice (9 days after birth) that approximates the stage of brain development in humans at birth after full-term pregnancy. The mice were then implanted with micro-transmitters that enabled the researchers to collect an uninterrupted stream of data on sleep, muscle movement, and activity levels. Data collection continued through 12 weeks of age, a time point considered to represent adulthood in mice.
Carlezon, who is a professor of psychiatry at Harvard Medical School, and his team discovered that temporary immune system activation shortly after birth produced two main findings in the adult mice. First, immune-activated mice spent more time in slow-wave sleep, a sleep phase often associated with systemic inflammation. Second, the mice also showed dramatic increases in brief (lasting 2-3 seconds) bouts of abnormal brain wave activity. These events had the hallmark characteristics of spike-wave discharges (SWDs), a type of epilepsy-like brain activity that is not accompanied by full-body seizures. Although the SWDs occurred throughout the day, they were much more prevalent during periods when the mice were sleeping. When they occurred during wakefulness, they were accompanied by complete behavioral arrest -- a period of no movement throughout the body -- and immediately followed by recovery of normal brain activity and movement. Collectively, these findings demonstrate that even a brief period of immune system activation during critical periods of early development can leave a long-term signature upon the brain.
Um yeah, been there, done that.
Geez Louise, oh me oh my...

Monday, January 8, 2018

See the Pathology

See the microbes that control his head.

Looks like his entire salivary system on that side is infected now.
It's more noticeable in the video.





Sunday, January 7, 2018

Very Stable Genius

Jumps through the mirror and becomes a human keleidoscope:

"Ronald Reagan had the same problem and handled it well. So will I!"