Monday, December 23, 2019

Gone Surfing

I'm going to try to ignore this blog again.
I need to hide inside my head and surf databases for a while.

It's now clear to me that Narcolepsy, Cataplexy, Alzheimer's, Tourette's, Parkinson's, Fibromyalgia, Multiple Sclerosis, Schizophrenia, Depression, Anxiety, PTSD, Obsession, Rape, Suicide, and Murder- all of them can be triggered by untreated head and throat infections.  

I have most of the information, I just need to document the insanity.
It will take a while, but I am ready now. I feel better lately and the words are coming out fast and furious.  I will cruise my mangled neurons and catalog the imperceptible pathology.
I'll tell you when my website is rewritten.

Friday, September 20, 2019

See the Porphyromonas Gingivalis

The uppers are gone, that's a denture up there.



Update:  heh.
Sep 20
Big teaching moment in the Lassner household. Making my kids watch last night’s Rudy Giuliani interview to show them what can happen when you let your teeth rot and it seeps into your brain.

Wednesday, August 14, 2019

Two Things that Change Minds

Have we found the true cause of diabetes, stroke and Alzheimer's?

The diseases most people die of have been attributed to unhealthy lifestyles. But evidence now suggests bacteria are to blame, heralding a revolution in medicine.
Strikingly, many of the afflictions of ageing – from rheumatoid arthritis to Parkinson’s – are more likely, more severe, or both, in people with gum disease. It is possible that some third thing goes wrong, leading to both gum disease and the other maladies. But there is increasing evidence that the relationship is direct: the bacteria behind gum disease help cause the others.
...

In January, teams at eight universities and the San Francisco company Cortexyme found a protein-digesting enzyme called gingipain, produced only by P. gingivalis, in 99 per cent of brain samples from people who died with Alzheimer’s, at levels corresponding to the severity of the condition. They also found the bacteria in spinal fluid. Giving mice the bacteria caused symptoms of Alzheimer’s, and blocking gingipains reversed the damage.
Moreover, half of the brain samples from people without Alzheimer’s also had gingipain and amyloid, but at lower levels. That is as you would expect if P. gingivalis causes Alzheimer’s, because damage can accumulate for 20 years before symptoms start. People who develop symptoms may be those who accumulate enough gingipain damage during their lifetimes, says Casey Lynch at Cortexyme.
...

P. gingivalis may literally break our hearts too. There is growing evidence for a causal link to atherosclerosis, or “hardening of the arteries”. Researchers have found P. gingivalis in the fatty deposits that line arterial walls and cause blood clots. When bits of clots clog blood vessels in hearts or brains, they cause heart attack and stroke.
The bacteria trigger the molecular changes in artery linings that are typical of atherosclerosis, says Genco. We have also found that P. gingivalis creates the lipoproteins thought to trigger atherosclerosis, causes it in pigs and affects arteries much like high fat diets. Lakshmyya Kesavalu at the University of Florida, who has cultured viable P. gingivalis from the atherosclerotic aortas of mice, calls the bacteria “causal”.
...

The link is clearer for type 2 diabetes, in which people lose sensitivity to insulin and eventually can’t make enough to control blood sugar. It is currently a pandemic, blamed on the usual lifestyle suspects.
Diabetes worsens gum disease, because high blood sugar levels hurt immune cells. But gum disease also worsens diabetes, and treating it helps as much as adding a second drug to the regimen taken by someone with the condition, according to the American Academy of Periodontology. Treatment is now recommended by diabetes associations, yet none of them list gum disease as a risk factor. As with other conditions, there is evidence that P. gingivalis isn’t promoting diabetes just by adding to the body’s inflammatory load, but may also be acting directly in the liver and pancreas to cut insulin sensitivity.

“It is very hard to prove causation in a complex disease,” says Genco. We know that mice given a mouthful of P. gingivalis get gum disease – and diabetes, rheumatoid arthritis, atherosclerosis, fatty liver disease and Alzheimer’s-like symptoms. We know that, in humans, gum disease makes the other diseases more likely, and that P. gingivalis lurks in the affected tissues and makes the precise cellular changes typical of these conditions.

This article is worth every penny of the $25 dollars I just spent to renew my subscription. And I already knew most of it.   I hope your library can get you access.  I can't copy and paste all of it.

This is the most important thing happening on the planet right now.
This is a fundamental paradigm shift that affects every single one of us.
In normal times this would be getting a lot of coverage.

But nooooooooo.... we can't have basic science or simple solutions or good news anymore.....instead we must spend every byte of every communication medium panicking over the apocalyptic antics of one very extreme case of this pathology....



And on that theme:
This is the toothpaste I have been looking for.

Cleure Natural Baking Soda Toothpaste
I look for unflavored toothpaste because the mint and fruit and bubblegum ones taste so gross.  I really like this one.   It's slightly sweet.  This stuff feels so good, not foamy or waxy, leaves my gums much happier, and my sad old teeth smoother and whiter than anything else I've tried.   Totally worth the price.

Thursday, August 8, 2019

Sunday, June 23, 2019

Cheap and Cruel

Malevolence exacerbated by incompetence.

An attorney "met one 16-year-old mother whose 8-month-old baby was sick with the flu and forced to sleep outside for four days... The mother said the guards took the clothing off the baby’s back, leaving her in a diaper, and forced them to sleep on concrete without a blanket."

A completely preventable infectious and immunological nightmare.
Because of this, I will never forgive any woman who voted for Trump.

Please donate to one of these organizations.

Saturday, May 25, 2019

One for the Freudians


Don't EVER call us Hysterical again, you self-serving asshats...


Further Adventures in Pain Insensistivity

Porphyromonas gingivalis is a gram negative bacteria.  The endotoxin in the cell wall of P gingivalis REDUCES PAIN SENSATION, so you don't know it's there.
Your first clue is when you can't remember things.

Go effin figure.

Thursday, May 23, 2019

Zombie Shopping List

I use almost all of these products on a regular basis, because I have found they reduce my mouth problems and cognitive weirdness.
Y'all seem to like Chile Chocolate, I am partial to cream cheese with taco sauce.
Go Figure.

These are things that are known to inhibit Porphyromonas gingivalis, which causes gingivitis.

P. gingivalis is the most probable cause of  Alzheimer's Disease. 

Please do not use antibiotics or hydrogen peroxide.   They disrupt the entire microbial balance in your mouth.

===========================


BAKING SODA
A four-week clinical study to evaluate and compare the effectiveness of a baking soda dentifrice and an antimicrobial dentifrice in reducing plaque.
The results of this study indicate that the baking soda dentifrice was more effective than the non-baking soda, antimicrobial dentifrice in plaque removal after a single tooth brushing, and in maintaining significantly lower plaque levels during a four-week period of twice daily, unsupervised tooth brushing.

GREEN/WHITE TEA
Suppresses P. gingivalis and helps your gums resist it too.

Antibacterial, antiadherence, antiprotease, and anti-inflammatory activities of various tea extracts: potential benefits for periodontal diseases.
Extracts from green tea, white tea, oolong tea, and black tea show promise for controlling periodontal disease by their capacity to interfere with P. gingivalis growth and virulence properties, host destructive enzymes, and inflammatory mediator secretion.

Green tea polyphenols enhance gingival keratinocyte integrity and protect against invasion by Porphyromonas gingivalis
These deleterious effects mediated by P. gingivalis were abolished by the green tea extract and EGCG. This protection may be in part related to the ability of tea catechins to inhibit the protease activities of P. gingivalis.

RED WINE
Both resveratrol and low concentration alcohol inhibit P. gingivalis

Resveratrol inhibits Porphyromonas gingivalis lipopolysaccharide-induced endothelial adhesion molecule expression

MILK/CHEESE
Lactoferrin and k-Casein in milk and cheese are preventative too.

Lactoferrin inhibits Porphyromonas gingivalis proteinases and has sustained biofilm inhibitory activity.

Porphyromonas gingivalis Cysteine Proteinase Inhibition by κ-Casein Peptides

LACTOBACILLUS
A probiotic bacteria available at the Health food store. Mostly available in multiple species pills.
Look for this strain on the label: L. Rhamnosus.  It helps me a lot.

Lactobacillus rhamnosus could inhibit Porphyromonas gingivalis biofilm formation
The immunomodulatory probiotic strain L. rhamnosus ATCC 9595 is proposed to be essential for maintaining healthy tissue, with multiple roles including co-aggregation, adhesion, and priming immune responses to ensure rapid and efficient defense against P. gingivalis.

DARK CHOCOLATE
Clinical and biochemical effects of dark chocolate in moderate chronic periodontitis
Consuming dark chocolate could decrease lipid peroxidation, gingival bleeding and inflammation.

FISH OIL/VITAMIN D
I think you have to use the real deal and put the liquid in your mouth.  I use drops in my coffee.

Omega-3 fatty acid reduces Porphyromonas gingivalis-induced experimental periodontal disease in rats.

CAPSAICIN (Chile spice)
Capsaicin inhibits Porphyromonas gingivalis growth and biofilm formation

CURCUMIN
Curcumin is a bright yellow chemical produced by turmeric, a member of the ginger family. It is sold as an herbal supplement. I have good reports on this one, but haven't tried it yet.

Novel therapeutic approach for the treatment of periodontitis by curcumin.

CRANBERRY
I have never tried thisI think there are extracts available.

Inhibitory effect of cranberry polyphenol on biofilm formation and cysteine proteases of Porphyromonas gingivalis.

A KETOGENIC DIET HELPS TOO
Enhancement of Wound Healing with Dietary Ketosis

If you must eat carbs, Rice has anti-gingivalis activity and sticks to your teeth less than other grains.

METFORMIN
A diabetes drug.  Tightens epithelium.  If you are taking this, stay on it.

STATINS
Atherosclerosis is also associated with P. gingivalis.  Cardiac plaque is probably the same as dental plaque (a theory proposed by Leonardo DaVinci.  Seriously.)

Effects of statins on multispecies oral biofilm identify simvastatin as a drug candidate targeting Porphyromonas gingivalis.
All four tested statins efficiently inhibited P. gingivalis growth and significantly decreased the cumulative bacterial load in developing and established biofilms. Simvastatin was most efficient and decreased P. gingivalis counts more than 1,300-fold relative to the control.

I'm gonna get me some of that.

NICOTINE

Tightens up your epithelium, so your gums bleed less.
But the tars and particles from cigarettes destroy the tissues in other ways.
You should use gum or vapes, and try to quit later when your mouth has healed.

For the record, my dentists never brought up gum disease in my entire life.
Much less offered me non drug options to prevent it.   I learned all this on my own.
Surgery is how they make money.
They were perfectly happy to ignore everything until I needed teeth extracted.

Friday, May 17, 2019

Yo Dr. Mignot

Fuck You, Motherfucker.
We told you over a decade ago it was gastrointestinal.
See the Fucking Vortex.

Lipopolysaccharide Challenge Reduces Orexin Production

Lipopolysaccharide (LPS) is a microbial toxin, produced during gram-negative bacterial infection.
Injecting animals with LPS reduces Orexin production, just like an infection.

**New Research** Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier 

Low orexin levels allow LPS from your microbiome to leak through your intestine into the bloodstream (endotoxemia),  which causes even more orexin dysfunction.  (!!!!!)

Hypocretin/orexin loss changes the hypothalamic immune response

The hypothalmic response to LPS challenge in orexin deficient animals is to cease orexin production altogether.

Effects of inflammation produced by chronic lipopolysaccharide administration on the survival of hypocretin neurons and sleep.

Long term endotoxemia kills orexin cells.

Monday, May 13, 2019

Three Strikes and You're OUT

Infection with the influenza virus causes massive lung damage, raising endotoxin levels drastically, which lowers orexin levels.
Endotoxin reduces the immune response to many bacterial infection, so those are common afterwards.

Strep and staph bacteria then give you another big dose of endotoxin by causing open lesions.

And then the antibiotics they give you burst the bacteria and release A LOT more endotoxin, which shuts down your orexin production completely.

Low levels of orexin impairs healing and promotes intestinal permeability which allows all that endotoxin to leak into your bloodstream constantly,  finally killing the orexin cells.

Saturday, May 11, 2019

THIS IS WHY

Because my mother and my doctors regularly dosed me with beta lactam antibiotics when I was a child.

Then they proceeded to tell me I was a stupid, lazy, ungrateful human when I got fat and tired and weepy.
And to just "Snap Out of It"...
And to just eat more frakking fruits and vegetables...

Thursday, May 9, 2019

No, I'm not asleep

Please-  If any of you know people on Suvorexant, beg them to discontinue using it.
If they have bad teeth or get an infection, they may end up in the vortex too.

Sunday, May 5, 2019

Links I forgot about

The crippling thing about growing up poor that stays with you forever
Terrible diets cause dysfunctional glucose regulation.

The woman who can smell Parkinson's disease
more evidence for my hypothesis that this is a respiratory fungal infection.

The Five Stages of Decay Cupcake

What If Global Warming Were Global Cooling?

Study finds natural selection favors cheaters

People with schizophrenia experience emotion differently from others, 'body maps' show

How a Little Known Native-American Tribe Is Leading the Way to Better Dental Care in America

What makes humans unique among animals
Dolphins have cultural transmission; many animals learn. But only humans teach

Military Doctors Told Them It Was Just "Female Problems."

School shooters usually show these signs of distress long before they open fire
Our analysis found that about 80 percent of mass school shooters were suicidal, based on records we have gathered thus far. This includes the Parkland shooter. Almost all of them die at the scene of the shooting, often by their own hand.

The parking lot suicides
Veterans are taking their own lives on VA hospital campuses, a desperate form of protest against a system that they feel hasn’t helped them.

Negative mood signals body's immune response


Oropharygeal Adjacent Articles

Men with Beards shed a lot of pathogenic bacteria
I have been wondering about that for a long time.

Artificial intelligence can diagnose PTSD by analyzing voices
I'm guessing it's microbial biofilm related nerve dysfunction...

The history of humanity in your face

The Truth About Dentistry
It’s much less scientific—and more prone to gratuitous procedures—than you may think.

Why I do not Pray

Because I have lived a lifetime proving that prayer has absolutely no effect on endotoxin.

RIP  Rachel Held Evans.