Thursday, August 25, 2016

This is Why

Good Lord. Even the Price of Insulin Is Skyrocketing.

Yeah, my husband noticed this a while ago.
It's not just the "orphan" drugs anymore.

It's a truly awesome thing, this drug dependence spiral.
These companies are the same ones who sell the antibiotics that cause diabetes...and allergies...

Friday, August 19, 2016

Good News

FDA Fast-Tracks Ketamine for Depression Treatment


Hey Bruce-
Tick Tock.
Say Buh-Bye to your Zombie patient pool...

Thursday, August 18, 2016

See the Vortex

The daily struggle of living with extreme fatigue
After many injuries and neurological illnesses, people often face a mysterious, unimaginable exhaustion that can last for years.

 The older you are, the worse the hospital is for you
The unique needs of older patients are not a priority for most hospitals, experts say.

Wednesday, August 17, 2016

For the Geeks

Sorry I have been slacking off on the blog again.    I am starting to work on my book.   I have been collecting and sorting all of my notes and citations and previous essays and all that.
I'm cleaning my brain.   Extreme cognitive purging.

Anyhow, I am also reading a few new things before I get started on the actual writing.


This book was pretty good:
The Human Superorganism: How the Microbiome Is Revolutionizing the Pursuit of a Healthy Life

Today I am reading this review. 
Commensal–Pathogen Interactions along the Human Nasal Passages

So Exciting!

Saturday, August 13, 2016

A Few for You

Period Pain Drug Can Cure Alzheimer’s Disease, New Study Suggests
This is a correlational study using behavioral metrics of mouse memory.   It has not been tested for anti-beta-amyloid effects, although most NSAIDs help reduce endotoxin effects somewhat.
Menstrual cramps seem to more attractive for headlines,   but Mefenamic acid is very commonly used for TOOTHACHES.  Head infections.  Go figure.

Botulinum toxin study proves possibility of remote effects
When Botox and related botulinum drugs entered the market, "the idea was that they are safe to use, they stay where they are injected, and you don't have to worry about toxin going to the central nervous system and causing weird effects," says Edwin Chapman, an investigator at the Howard Hughes Medical Institute and professor of neuroscience at the University of Wisconsin-Madison.
The concern that this powerful toxin can move beyond the injection site was reinforced in 2009, when the Food and Drug Administration added a prominent warning to prescribing information "to highlight that botulinum toxin may spread from the area of injection to produce symptoms consistent with botulism," including "unexpected loss of strength or muscle weakness. ... Understand that swallowing and breathing difficulties can be life-threatening and there have been reports of deaths related to the effects of spread of botulinum toxin."
In a study published today (Aug. 4, 2016) in Cell Reports, senior author Chapman, first author Bomba-Warczak and colleagues present clear evidence that toxin is moving between neurons in a lab dish.
Using VR technology, an exoskeleton and software, study claims participants have unexpectedly experienced partial recovery of movement and sensation.

Students in government-funded school meal programs at higher risk of being overweight 
"We found that the longer children were in the programs, the higher their risk of being overweight. We also saw the most negative effect of the government-funded school meal programs in the South, the Northeast, and rural areas of the country," You said. "The question now is what to do in order to not just fill bellies, but make sure those children consume healthy and nutritious food -- or at least not contribute to the obesity epidemic."
Not to mention insulin resistance contributes to cognitive problems....

Librarians Have an Olympics, Too


Endurance Starvation Was Once a Crowd-Pleasing Sport

Wednesday, August 10, 2016

You Don't Say

Infection Linked to Large Increased Risk for Death by Suicide
Infection requiring hospitalization has been linked to a 43% increased risk of dying by suicide. The finding raises questions about the role of biological mechanisms of infection, particularly neuroinflammation, on suicidal behaviors.
"Our findings indicate that infections may have a relevant role in the pathophysiological mechanisms of suicidal behavior," the investigators, with first author Helene Lund-Sørensen, BM, Copenhagen University Hospital, Denmark, write.
"To our knowledge, this investigation is the largest study to date to examine infections as a predictor of death by suicide," they report.
The researchers also note that although "psychiatric disorders and previous suicide attempts might constitute stronger predictors of suicide, we found that hospitalization with infection accounted for a population-attributable risk of 10.1%.
"The implication is that 1 in 10 suicides could be prevented if infections were to be eliminated entirely, provided that the association was causal," they write.

Sunday, August 7, 2016

Future Moments in History

Google firm hopes to control organs with electrical signals

Yeah, Google collaborating with Glaxo-Smith-Klein sounds like a good start to creating a Matrix.   Whether that's the intention or not...

Saturday, August 6, 2016

This and That


Vaccines fail to protect obese mice from severe influenza infections

Hidden tooth infections may predispose people to heart disease

Blood sugar slumps affect how lean men treat the more rotund
Low blood sugar makes them cruel.   Shocking, isn't it?

A simple treatment for a common breathing problem among premature infants
This is so fascinating, they put electrodes on their hands and feet and make their brains think they are running.  

Discovery of infants' airway microbiomes may help predict lung disease
In contrast to the general belief that the airways of an infant are sterile until after birth, University of Alabama at Birmingham researchers and colleagues have found that the infant airway is already colonized with bacteria or bacterial DNA when a baby is born—and this is true for infants born as early as 24 weeks gestation.
Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine.
 I knew it... liked a lot of stimulants, but not cocaine.    Pretty sure this effect is the cause of the meth epidemic...

Thursday, August 4, 2016

My Two Cents

Trump is in a manic bacteriotoxic spiral and he's likely to have a yuge stroke or heart attack.   The best one ever.

(oh, and Clint-  your crazy is showing again.   You might want to tuck that back in.)

Tuesday, August 2, 2016

ICYMI

Speaking of conclusions made without any empirical evidence-

Everyone recommends flossing – but there's hardly any proof it works
Dental organizations and the federal government have long urged people to use dental floss, but the latest US guidelines have dropped the recommendation.
Without notice.   Because that is pretty damn embarrassing.

Monday, August 1, 2016

Zombie News Today

Florida just announced that mosquitoes are probably transmitting Zika in the US
"Zika is now here."

Girl Talk

 Mystery of the female orgasm may be solved
 While men need to orgasm in order to transfer sperm, women end up with the nerve and muscle tissues for orgasm as “a fantastic bonus”.

Could Women Be Trusted With Their Own Pregnancy Tests?
Unmarried teenagers would jump off bridges, and other crazy reasons at-home kits weren’t approved until the late 1970s.

The tale of the home pregnancy test is not unique. Breakthroughs that give patients control over their bodies are often resisted. Again and again, the same questions come up: Are patients smart enough? Can they handle bad news? And do they have the right to private information about their bodies?
One of the most enduring themes in medical history is:  Men have insisted they were the rational ones while making outlandish conclusions about women based on no empirical data whatsoever.

Sunday, July 31, 2016

Weekend Drive-By

Sorry about the radio silence.
We are transitioning four apartments and selling our house this week.
And the temperature has been in the hundreds for two months.
Already had a spectacular tantrum, just trying to avoid respiratory failure at this point.

Here's some stuff I've been collecting

Study says one in ten Americans has buzzing in the ear or tinnitus

Most powerful obesity gene yet boosts risk by 40 per cent
To investigate how CREBRF promotes weight gain, the team genetically engineered fat cells in the lab to express the obesity-associated variant. They found that this caused the cells to store more fat and release less energy, as if they are trying to conserve as much fuel as possible.
This thriftiness is likely to be advantageous during periods of food scarcity, but lead to obesity in times of nutritional excess, says team member Stephen McGarvey at Brown University.
FDA Strengthens Warning on Powerful Antibiotics
The Food and Drug Administration strengthened the warnings about one type of antibiotic Tuesday, saying they're too strong to be used for sinus infections, bronchitis and simple urinary tract infections.
The drugs are in a class called fluoroquinolones and include levofloxacin (as known as Levaquin) and ciprofloxacin (Cipro). They can cause serious and sometimes permanent side-effects.
"While these drugs are effective in treating serious bacterial infections, an FDA safety review found that both oral and injectable fluoroquinolones are associated with disabling side effects involving tendons, muscles, joints, nerves and the central nervous system," the agency said in a statement.

Resveratrol appears to restore blood-brain barrier integrity in Alzheimer's disease
Resveratrol, given to Alzheimer's patients, appears to restore the integrity of the blood-brain barrier, reducing the ability of harmful immune molecules secreted by immune cells to infiltrate from the body into brain tissues, say researchers at Georgetown University Medical Center.

Ketone drink gives competitive cyclists a boost by altering their metabolism
A drink developed for soldiers to generate energy from ketones allowed highly trained cyclists to add up to 400 meters of distance to their workouts, a new study reports. The supplement, which will be commercially available within the year, works by temporarily switching the primary source of cellular energy from glucose or fat to ketones -- molecules derived from fat that are known to be elevated in people consuming a low-carb, Atkins-like diet. 

To protect yourself from malaria sleep with a chicken next to your bed
For the first time, scientists have shown that malaria-transmitting mosquitoes actively avoid feeding on certain animal species such as chickens, using their sense of smell. Odors emitted by species such as chickens could provide protection for humans at risk of mosquito-transmitted diseases
Altruism is favored by chance
Mathematicians may have found an answer to the longstanding puzzle as to why we have evolved to cooperate