Thursday, August 8, 2019

Yo Dr. Mignot

Fuck You, Motherfucker.
We told you over a decade ago it was gastrointestinal.
See the Fucking Vortex.

Lipopolysaccharide Challenge Reduces Orexin Production

Lipopolysaccharide (LPS) is a microbial toxin, produced during gram-negative bacterial infection.
Injecting animals with LPS reduces Orexin production, just like an infection.

**New Research** Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier 

Low orexin levels allow LPS from your microbiome to leak through your intestine into the bloodstream (endotoxemia),  which causes even more orexin dysfunction.  (!!!!!)

Hypocretin/orexin loss changes the hypothalamic immune response

The hypothalmic response to LPS challenge in orexin deficient animals is to cease orexin production altogether.

Effects of inflammation produced by chronic lipopolysaccharide administration on the survival of hypocretin neurons and sleep.

Long term endotoxemia kills orexin cells.

Monday, May 13, 2019

Three Strikes and You're OUT

Infection with the influenza virus causes massive lung damage, raising endotoxin levels drastically, which lowers orexin levels.
Endotoxin reduces the immune response to many bacterial infection, so those are common afterwards.

Strep and staph bacteria then give you another big dose of endotoxin by causing open lesions.

And then the antibiotics they give you burst the bacteria and release A LOT more endotoxin, which shuts down your orexin production completely.

Low levels of orexin impairs healing and promotes intestinal permeability which allows all that endotoxin to leak into your bloodstream constantly,  finally killing the orexin cells.

Saturday, May 11, 2019

THIS IS WHY

Because my mother and my doctors regularly dosed me with beta lactam antibiotics when I was a child.

Then they proceeded to tell me I was a stupid, lazy, garbage human when I got fat and tired and weepy.
And to just "Snap Out of It"...
And to just eat more frakking fruits and vegetables...

Thursday, May 9, 2019

No, I'm not asleep

Please-  If any of you know people on Suvorexant, beg them to discontinue using it.
If they have bad teeth or get an infection, they may end up in the vortex too.

Sunday, May 5, 2019

Links I forgot about

The crippling thing about growing up poor that stays with you forever
Terrible diets cause dysfunctional glucose regulation.

The woman who can smell Parkinson's disease
more evidence for my hypothesis that this is a respiratory fungal infection.

The Five Stages of Decay Cupcake

What If Global Warming Were Global Cooling?

Study finds natural selection favors cheaters

People with schizophrenia experience emotion differently from others, 'body maps' show

How a Little Known Native-American Tribe Is Leading the Way to Better Dental Care in America

What makes humans unique among animals
Dolphins have cultural transmission; many animals learn. But only humans teach

Military Doctors Told Them It Was Just "Female Problems."

School shooters usually show these signs of distress long before they open fire
Our analysis found that about 80 percent of mass school shooters were suicidal, based on records we have gathered thus far. This includes the Parkland shooter. Almost all of them die at the scene of the shooting, often by their own hand.

The parking lot suicides
Veterans are taking their own lives on VA hospital campuses, a desperate form of protest against a system that they feel hasn’t helped them.

Negative mood signals body's immune response


Oropharygeal Adjacent Articles

Men with Beards shed a lot of pathogenic bacteria
I have been wondering about that for a long time.

Artificial intelligence can diagnose PTSD by analyzing voices
I'm guessing it's microbial biofilm related nerve dysfunction...

The history of humanity in your face

The Truth About Dentistry
It’s much less scientific—and more prone to gratuitous procedures—than you may think.

Why I do not Pray

Because I have lived a lifetime proving that prayer has absolutely no effect on endotoxin.

RIP  Rachel Held Evans.

Saturday, May 4, 2019

For some reason I have been reminded of this old joke a lot lately

One day the different parts of the body were having an argument to see which should be in charge.
The brain said, “I do all the thinking so I’m the most important and I should be in charge.”
The eyes said, “I see everything and let the rest of you know where we are, so I’m the most important and I should be in charge.”
The hands said, “Without me we wouldn’t be able to pick anything up or move anything. So I’m the most important and I should be in charge.”
The stomach said, “I turn the food we eat into energy for the rest of you. Without me, we’d starve. So I’m the most important and I should be in charge.”
The legs said, “Without me we wouldn’t be able to move anywhere. So I’m the most important and I should be in charge.”
Then the rectum said, “I think I should be in charge.”
All the rest of the parts said, “You?!? You don’t do anything! You’re not important! You can’t be in charge.”
So the rectum closed up.
After a few days, the legs were all wobbly, the stomach was all queasy, the hands were all shaky, the eyes were all watery, and the brain was all cloudy. They all agreed that they couldn’t take any more of this and agreed to put the Asshole in charge.

Wednesday, May 1, 2019

Uh Huh

A four-week clinical study to evaluate and compare the effectiveness of a baking soda dentifrice and an antimicrobial dentifrice in reducing plaque.

The results of this study indicate that the baking soda dentifrice was more effective than the non-baking soda, antimicrobial dentifrice in plaque removal after a single tooth brushing, and in maintaining significantly lower plaque levels during a four-week period of twice daily, unsupervised tooth brushing.

Enhancement of plaque removal efficacy by tooth brushing with baking soda dentifrices: results of five clinical studies.

The collective results from the five controlled clinical studies on over 270 subjects reported in this paper, consistently demonstrate that Arm & Hammer baking soda dentifrices enhanced plaque removal effectiveness of tooth brushing to a significantly greater extent than the non-baking soda dentifrice products.

Bonus:   Green/White Tea suppresses P.gingivalis and helps your gums resist it too.

Sunday, March 31, 2019

Constant Ticcing

I am having a real hard time thinking about this.
I have been telling my doctors and dentists my brain problems come from my effin teeth for a decade.
They have rolled their eyes at me.
And taken my money anyway.

The only reason I am alive is because I didn't listen to them.

I can't look at much research because I am tired of screaming right now.
I am very exhausted from living in this mirror.

Anyway, here's the one search I could manage.

Orthodontic brackets increase levels of porphyromonas gingivalis.
(and the tissue wounds that transfer bacteria to the brain...)

Yeah, I had braces for nine years before I was 21.


I'm pretty sure that living in an Alzheimer's facility, eating pancakes, and not remembering to brush your teeth does the same thing...

Wednesday, March 27, 2019

Tic Tic Tic Tic Tic

We may finally know what causes Alzheimer’s – and how to stop it
Multiple teams have been researching Porphyromonas gingivalis, the main bacterium involved in gum disease, which is a known risk factor for Alzheimer’s. So far, teams have found that P. gingivalis invades and inflames brain regions affected by Alzheimer’s; that gum infections can worsen symptoms in mice genetically engineered to have Alzheimer’s; and that it can cause Alzheimer’s-like brain inflammation, neural damage and amyloid plaques in healthy mice.

“When science converges from multiple independent laboratories like this, it is very compelling,” says Casey Lynch of Cortexyme, a pharmaceutical firm in San Francisco.

Now researchers from Cortexyme and several universities have reported finding the two toxic enzymes that P. gingivalis uses to feed on human tissue in 99 and 96 per cent of 54 human Alzheimer’s brain samples taken from the hippocampus – a brain area important for memory (Science Advances, doi.org/gftvdt). These protein-degrading enzymes are called gingipains, and they were found in higher levels in brain tissue that also had more tau fragments and thus more cognitive decline.

The team also found genetic material from P. gingivalis in the cerebral cortex – a region involved in conceptual thinking – in all three Alzheimer’s brains they looked for it in.

“This is the first report showing P. gingivalis DNA in human brains, and the associated gingipains co-localising with plaques,” says Sim Singhrao at the University of Central Lancashire, UK, who wasn’t involved in the study. Her team has previously found that P. gingivalis actively invades the brains of mice with gum infections.

Friday, March 1, 2019

Everywhere. Always.

Endotoxic Masculinity

Monday, December 24, 2018

Saturday, December 15, 2018

See the Vortex

I never thought he was snorting cocaine in recent years.
surely back in the eighties he did.
but now it's too risky.

snorting lines of adderall makes tons of sense.
less legal liability, more availability and fits symptomatically.
that will  totally fuck up your nose and sinuses and cranial nerves.

white neuroticism in a pill.