These top 10 causes of death accounted for almost 75% of all deaths in the U.S. in 2021:
- Heart disease (695,547)
- Cancer (605,213)
- COVID-19 (416,893)
- Accidents (224,935)
- Stroke (162,890)
- Chronic lower respiratory diseases (142,342)
- Alzheimer’s disease (119,399)
- Diabetes (103,294)
- Chronic liver disease and cirrhosis (56,585)
- Kidney disease (54,358)
7 of them can be directly linked to one microbe. One microbe that infects human heads.
2 are caused by drinking alcohol to ease the misery of the
infection.
That’s insane. It’s ridiculous. But it’s true.
I think everyone on the planet needs to know this, but nobody I meet has heard of it. Not even medical staff. All the articles are written in scientific format and language that untrained people can’t read. I am a medical librarian and I can’t even understand them when I’m sick.
I am going to simplify the language and put my references elsewhere. I am going to minimize the use of abbreviations and italics to avoid confusion. I am going to oversimplify a lot of processes for brevity. The details really aren’t necessary to get the big picture. The great thing about this research is it simplifies so many things. It solves so many mysteries. It’s going to make things so much easier.
Don't try to remember everything. I have kept each section mostly self-contained. If I mention a chemical, I will explain it within a couple sentences. I have bolded the important terms to remember.
Almost all the information I am using is contained in these review articles. They are long detailed explanations of the conditions known to be caused or facilitated by Porphyromonas gingivalis.
Porphyromonas
gingivalis and Its Systemic Impact: Current Status
Porphyromonas
gingivalis, a Long-Range Pathogen: Systemic Impact and Therapeutic Implications
------------------------------------------------
Alzheimer’s for Zombies
Despite what you may believe: Alzheimer’s Disease is not a mystery. The people who research it know pretty well how it works. I can explain the basics in one page. They just haven’t figured out a way to sell you a patented treatment yet. Treatments might be obsolete soon though; it’s going to be preventable in the near future. There are already effective vaccines for mice.
Alzheimer’s disease is defined by the buildup of molecules called Tau and Beta Amyloid in the brain. This is thought to cause the dementia symptoms. There are many other changes that occur, but the buildup of these molecules in the brain is the definitive marker of the disease.
What researchers do know is that this brain damage in Alzheimer’s is caused by immune reactions to very common infections. There are multiple infections that trigger this immune response, and a gene that makes it progress more rapidly in certain people. Different combinations are possible. I am going to concentrate on the two most pervasive infections and the gene, because they cause the vast majority of the cases.
Beta Amyloid (βA). is the main component of amyloid
plaques, extracellular deposits found in the brains of people with
Alzheimer's disease.
It is a molecule
released by neurons and has been shown to impede the growth of microbes in the
brain.
The production of βA is normally counterbalanced by its degradation by several processes that operate in the brain, however during acute infection they can be overwhelmed and βA can accumulate.
- Beta amyloid production is increased by the bacterium Porphyromonas gingivalis (PG) which infects the mouth and causes gum disease.
- The Herpes 1 virus (HSV1), which causes mouth lesions, also increases beta amyloid production.
Tau is a protein that forms microtubules in the
neuron which support the internal structure.
Hyperphosphorylation of tau alters it shape so it isn’t straight and can’t be degraded. This causes it to cluster into aggregates called neurofibrillary tangles which result in the death of the neurons.
- Hyperphosphorylation of tau is strongly triggered by the Herpes 1 virus.
- P. gingivalis also induces tau hyperphosphorylation and accumulation of misfolded tau.
APOE4
The membranes of neurons contain a lot of cholesterol. Apolipoprotein E (APOE) is a cholesterol transport
molecule. Astrocytes (cells surrounding
the neurons) make it to transport cholesterol to the neurons. It has been shown to affect many of the
processes involved I have mentioned. APOE
exists in three main variants in humans- APOE2, APOE3, APOE4.
APOE4 is by far the major genetic variant linked to Alzheimer’s disease. APOE4 is less effective at these functions, and cell integrity is compromised.
· Astrocytes also collect the excess beta amyloid that neurons have dumped into the synapse. They internalize it and degrade it. APOE4 producing cells are slower at this.
·
Astrocytes form most of the blood-brain
barrier. It has been found that APOE4
leads to barrier breakdown, decreased cerebral blood flow, and neuronal loss.
·
APOE4 astrocytes exhibit a higher basal
expression of inflammation related molecules.
·
APOE4 seems to facilitate the entry and/or
spread of HSV1 in the brain much more efficiently than APOE3. Animals
expressing human APOE4 present very high levels of HSV1 in the brain when
compared to those expressing the APOE3 gene.
In contrast, there were no significant differences in the viral levels
found in organs which do not contain APOE.
The big fun twist is: HSV1 and P. gingivalis work together to create
openings and cross the blood-brain barrier.
People with recurring herpes and PG will not only have aggressive gum
disease, but more rapid brain damage as well.
HSV1 can be controlled with antiviral drugs. They have been shown to improve the symptoms of mild Alzheimer’s. I started taking Valacyclovir a decade ago because I have APOE4 and HSV1. That’s why I can type this, that’s why I am not already dead. It only slows the progression down though- because of the contribution of P. gingivalis. That’s what I learned during my most recent journey into the void…
There are very few drugs that work against P. gingivalis, and acquired resistance to them is common. Certain vaccines will probably be highly effective though. They have already shown efficacy in Alzheimer’s lab mice.
Curcumin/Turmeric is more effective than existing drugs
targeting P. gingivalis. It is a natural
product and has been effectively used in India to fight gum disease for
centuries. It improved my mouth and my
mind dramatically in a few weeks.
That is really good news because P. gingivalis is the most likely cause of many other problematic conditions. Like Cancer, Heart Disease, Diabetes and Arthritis- just for starters!
Porphyromonas Gingivalis- The Vampire Squid
This microbe is everywhere. It’s endemic all over the planet. It always has been. It is found in prehistoric human remains.
There are tons of population studies. The rates of antibody response run between 40-100%, correlating with the age of the patients. Here’s one set of results: detection of PG was found to be 91.5% in chronic periodontitis and 58% in healthy individuals.
P.
gingivalis was first isolated in the 1950's by H. Werner in Germany from an
undocumented human oral infection. Nobody
paid much attention to it until about fifteen years ago. There were many more glamorous things to
study… until DNA probes found P. gingivalis everywhere…
Periodontitis and missing teeth have always been linked to many other adverse health outcomes. Modern research has now confirmed the presence of this specific bacteria all over the body. That’s why they call gum disease a “risk factor”. Yeah, it’s way more than that. It is well documented that PG is an active participant in most of the progressive end-of-life diseases of humans. The ones they tell you are caused by drinking, smoking, and drugs….
Dental Plaque is a collection of bacteria that stick together. They can live on the teeth, gums, tongue, and throughout the mouth. The yellow film that a person sees on their teeth is plaque. P. gingivalis forms a black outline at the base of the teeth on the gumline too. PG and other species of bacteria can join together to form a biofilm. Biofilms are thick, sticky substances that protect bacteria, making them stronger and harder to remove. P. gingivalis forms very toxic, aggressive biofilms. P. gingivalis changes the entire oral microbiome and creates an environment that not only favors its growth and survival, but also facilitates the growth of many other pathological species.
If a person
does not remove plaque, it calcifies by trapping minerals from the saliva,
causing it to harden. This is called
calculus or tartar.
Now I have to explain a little about how P. gingivalis in your gums can cause problems all over the body.
Cell
infiltration, survival and cell to cell transport
PG doesn’t just sit on your teeth and make plaque. It invades the outer cells of your gums and cheeks right away. It takes about fifteen minutes to hack its way in. Then it multiplies and travels from cell to cell to other part of the head and neck. This mechanism of spreading allows PG to colonize tissues without exposure to the immune response.
- From there it can get into your cranial nerves and into the brain.
- It attaches to food and saliva and gets swallowed into your gastrointestinal tract.
- P. gingivalis LPS alters the mucous in your salivary glands. It reduces the levels of mucin, a molecule that defends against bacterial infections. Very diabolical.
- It can also get into your blood vessels and cells. It likes to get in your blood. PG really is like a vampire. It needs iron to survive and it likes to tap into your hemoglobin. It hitches rides around your body attached to your red blood cells. It will infiltrate and live in your white blood cells but not kill them.
- Don’t forget the lymphatic system, yes, it ends up in there too. It really likes closed tight spaces with epithelial linings like vessels and ducts.
It often joins other microbes or their chemical products around the body to do even more damage.
All that sneaking around is terrifying, but it also has a few short and long-range weapons in its toolkit.
Lipopolysaccharide
(LPS) - this is
the main molecule of the outer coating of pathogenic bacteria. It is shedding
and regenerating constantly. It is
recognized by the immune system and triggers the immune response. Particles of LPS can travel in the blood and
lymphatic system causing immune reactions in distant areas or throughout your
body.
Vessicles - are tiny spherical structures that surround
biologically active molecules. They are
continuously discharged from the bacterial
cell and spread around the body like package bombs. Vessicles have various
advantages including preventing the contents from degradation, and entry into
smaller spaces than the entire bacterium.
Gingipains - are 3 specific vessicles from PG bacteria
that cut through proteins and are used to extract the iron from hemoglobin. They are
pretty general implements though; they can cleave other proteins too. They destroy cytokines, which are the front
line host defense molecules. This
allows PG to and its friends to survive longer in the tissues.
Ready? Let’s explore some of the ways these little monsters
destroy lives.
These first four syndromes should sound familiar.
Atherosclerosis /Hypertension
Every little bit of this is known down to the molecular level. It is not a mystery.
When PG gets into your bloodstream it attaches to red blood cells to get the iron. This is important because red blood cells won’t be attacked by white blood cells, because they are not foreign bodies. It’s stealth vehicle technology.
PG then
teams up with Streptococcus mutans in the arteries. Strep mutans causes cavities in your
teeth. It goes through the holes it
makes and into your bloodstream too. They
get together and burrow into the walls of the blood vessels. Together with P gingivalis, S. mutans was found to
accelerate arterial plaque formation in mice and induce platelet aggregation,
which leads to clot formation.
Both PG and S. Mutans are found in human arterial plaques.
PG alters cholesterol levels!!!!
Total and LDL cholesterol levels were elevated and HDL cholesterol levels were decreased in P. gingivalis infected mice.
PG vessicles significantly increases vascular
permeability.
PG causes calcification of the blood
vessels.
It raises blood pressure!
Long term
exposure to PG precedes strokes!
P. gingivalis can affect both clot structure and mechanics.
- LPS from P. gingivalis caused the clot to become more dense
- Gingipain exposed clots seem to break free abruptly at lower stresses
Statin
drugs, which are prescribed for atherosclerosis, efficiently inhibit
P. gingivalis. Simvastatin was most efficient and decreased
P. gingivalis counts more than 1,300-fold relative to the control.
Cancer
P. gingivalis has been shown to induce cancer by altering the
host cell membrane, and promoting cancer cell proliferation.
PG is capable of converting alcohol into acetaldehyde, which destroys
host cell membranes. Acetaldehyde build
up can cause irreversible DNA damage, which can lead to tumor formation.
PG is capable of infiltrating and living in tumors and accelerates their growth. PG has also been shown to suppress the immune system, enabling survival of the tumors, as well as promoting chemotherapy resistance.
It is especially associated with tumors in the cells lining ducts and vessels. Epithelial squamous cell carcinoma.
The bacteria and their debris travel with food and saliva from the mouth into the esophagus and are associated with many cancers there. The stomach seems to kill a lot of it, live cells are much rarer in the intestines and colon. The vessicles survive and do plenty of damage, though.
Mouth and Throat-
P. gingivalis is highly correlated with all these cancers.
It’s found in the tumors. Levels of PG were positively correlated the clinical stage of the patient.
Lung - From the esophagus, PG can be inhaled into the lungs.
Colonization of P. gingivalis in carcinoma tissues was significantly higher than that in adjacent lung tissues.
Breast - Breasts have
ducts and are made to be in contact with mouths.
PG creates very resistant biofilms with fusobacterium at the gum line. PG and fusobacterium are found in breast cancer tumors. Fusobacterium is carcinogenic and seems to be the actual trigger for many breast cancers.
Diabetes/ Obesity
This
correlation has been known for ages and the causation has always been
assumed to go the other way: Diabetes
made gum disease worse. It looks like that was wrong…
P. gingivalis causes a systemic inflammatory response, disrupts insulin signaling pathways, reduces pancreatic β-cell function, and reduces their numbers. PG impairs glucose uptake in skeletal muscle and causes decreased insulin sensitivity leading to insulin resistance.
More specifically. the human hormone GLP-1, which induces secretion
of insulin from the pancreas, is degraded by PG bacterial cells and gingipain.
This is the
hormone you all are replacing with Ozempic.
You might want to rethink that.
Pancreatic Cancer
P. gingivalis survives inside pancreatic cancer
cells. Increased tumor cell proliferation was related
to the degree of intracellular persistence, and infection of tumor cells
with PG led to enhanced growth.
Rheumatoid Arthritis
This link
has also been known forever. Some of
the drugs for arthritis already target PG. I think these are the researchers
who are working on a vaccine.
P.
gingivalis and it vessicles have been found in the joints of arthritis
patients. It was assumed they were
linked, but there didn’t seem to be a difference in numbers between people with
arthritis and without.
Recently, PG
has been reported to produce a unique enzyme, which converts the terminal
molecules in proteins to citrulline.
It is now
clear that the majority of rheumatoid arthritis cases are triggered by an
immune response to the citrullinated proteins. Genetically susceptible
individuals generate antibodies against them. The antibodies cause the subsequent
development of RA.
Ankylosing
Spondylitis
Spinal
arthritis seems to be strongly associated with PG. Periodontal disease is very common in these
patients. Researchers used
moxifloxacin—an antibiotic used to treat P gingivalis —for AS treatment in
2007. Moxifloxacin was continuously effective in treating the symptoms and clinical
parameters of AS.
--------------------------------------------
Okay, that
was literally jaw dropping, let’s move on to all the other illnesses I found
along the way.
Salivary Glands
PG colonizes the salivary glands under your jaw. The submandibular and sublingual glands.
This is the easiest symptom to notice besides black teeth:
double chins. If you look closely, they
aren’t only made of fat. They are
swollen salivary glands. Weight gain is
a symptom too, but the large neck size is out of proportion.
Erectile Dysfunction
The function of penile erection is impaired by
periodontitis. The decreased nitric oxide activity in penile tissue caused by
mild systemic inflammation in periodontitis is one of the important risk
factors of ED.
Prostate disease- P gingivalis has been found in
prostatic secretions of men with both periodontal and prostate diseases.
Pregnancy
Studies confirm the presence of P.
gingivalis in the amniotic fluid and placenta of women with poor pregnancy
outcomes.
P. gingivalis is linked with the development of
preeclampsia, spontaneous abortion, gestational diabetes, low birth weight, and
misconception. The vessicles of PG can directly injure and alter the structure
and microbiome of fetal and maternal tissues. PG can even exaggerate the
production of inflammation in the uterus that increases the risk onset of
preterm labor.
Women who are breastfeeding are at a higher risk of cavities and gum infections. This is due to the fact that women who breastfeed lose up to 5 percent of their bone mass.
P gingivalis transfers from mother’s saliva to baby’s
saliva within 48 hours of birth.
Celiac Disease
P. gingivalis seems to trigger gluten intolerance in
people with certain genes.
The gingipains degrade cell junctions in the
intestine. Gluten also induces
intestinal permeability. This allows
gluten fragments to escape and trigger antibody production.
A long-term study in children showed that existing PG
infection was strongly associated with developing intestinal damage and celiac
antibodies.
This mechanism would also explain later onset gluten
intolerance.
Vision loss
This isn’t fully established, but it seems really
plausible.
There is about a 2-fold higher risk of macular
degeneration in patients with periodontal bone loss.
The risk of Diabetic retinopathy increases with PG
antibody levels.
Mice retinae showed signs of developing macular
degeneration when they were exposed to PG.
Live PG bacteria adhere to and invade human retinal cell
cultures.
Kidney Disease
Gingipains cause kidney damage by activating an
inflammatory response in the tissues.
Elevated serum antibodies to P. gingivalis were significantly associated with decreased kidney function.
There are clearly genetic factors involved in the
presentation of these symptoms. It seems
every family has some limited version of this.
Mine gets throat cancer and dementia.
My husband’s family have diabetes and heart attacks. Another I know has celiac and arthritis.
So, have we got the picture? This squid has tentacles everywhere. And they become obvious later in life. I need everyone to know there are a lot of earlier symptoms too.
Porphyromonas
Gingivalis- the ghost in the machine
Having gone over the many physical illnesses caused by PG, I can finally get to the reason I’m doing this. I have made a similar list of mental illnesses. I think many of them are caused by the unnoticed effects of the infection in its early stages.
What I’m saying is that Porphyromonas gingivalis will make you all kinds of crazy before your mouth gets bad enough that dentists actually do something.
I haven’t had all the physical symptoms yet. I’m getting there. I have an oral cancer now.
I have had almost all the mental problems that exist though. Even the really exotic ones. Hallucinations. Amnesia. Narcolepsy.
Sleepwalking. Tourettes…
First, let me explain something. Emotions are physical things. They are chemical signals of physical events
that you can’t feel directly or immediately.
This is because they are processes in areas that don’t have sensory
nerves. They are often processes that produce hormones instead. Hormones travel in the blood and don’t
trigger a feeling of location.
A good place to explain this is the gastrointestinal tract. You can feel your mouth and throat, part of your stomach and your anus. The rest of the intestines and organs don’t have sensory neurons to the brain. You can’t feel your guts directly. I suppose that’s a good thing since they are constantly busy. But it produces hormones and causes brain sensations that you can’t identify the source. These are primary emotions, good, bad, confident, uncertain, afraid. Sick.
Periodontal diseases, primarily gingivitis and periodontitis, are characterized by progressive inflammation and tissue destruction. However, they are not also accompanied by the pain commonly seen in other inflammatory conditions. This suggests that interactions between the bacteria and host cells create an environment in which the pain signals are inhibited.
The membrane of PG has this effect. The technical term is anti-nociceptive. Nociception is the perception of pain.
It has this effect because it attaches to capsaicin receptors. Capsaicin receptors actually transmit pain signals, but they are quickly overwhelmed and then shut down. Prolonged application of P. gingivalis LPS has this same effect. It interrupts the pain signals.
If you have this infection, you can’t feel it.
You will have all kinds of things going on in your body and never know it. You will have lots of inflammation and aches and pains. You will complain about everything but your mouth.
This is paradigm shifting. This explains a ton of things. Let me count the ways….
Depression
Of course it causes depression. All illnesses do. It’s one of the immune system reactions to infection. If there are microbes in your blood, your body will react in a number of ways. One of the first things it does is shut down your production of Orexin, an alertness neurotransmitter, which then makes you tired. What you are experiencing is the physical downshifting of your body’s activity to deal with microbe invasion. Depression is the emotional feeling of being in low gear. This microbe also seriously disrupts your glucose metabolism and that makes you hungry and exhausted.
The fact that it doesn’t resolve after distressing events shows that it’s not mental. You’re sick.
Anxiety
Of course it causes anxiety. All illnesses do if they don’t resolve. It’s the second stage of sickness. If you don’t get better, after a while your body will start to panic.
- Porphyromonas gingivalis is associated with high levels of cortisol in chronic periodontitis patients.
Bipolar
This is also easily explained as sickness behavior of
unknown origin.
Lethargy and demotivation. Anxiety and stress. Social isolation. Social seeking. Overconfidence. Despair.
These are symptoms of illness.
It vacillates because there is a constant interplay
between the infection and the immune system.
Sometimes you are worse, sometimes you are better. Since you can’t feel your mouth, you address
any other thing you can think of. Some people blame literally anything- aliens come to mind.
Occasionally you do go to the dentist and get your teeth
fixed and cleaned. This alters your
microbial burden, and you might recover for a while. You might get a sinus or urinary tract infection and take some
antibiotics. That will shift things
too.
The cycles get faster as you get sicker. Your sleep and metabolism deteriorate, and your blood sugar starts swinging wildly.
Any painless, hidden infection could cause this
effect. And it usually subsides because
the source of infection becomes obvious and treated.
But some of us have PG.
Some of us have always had PG.
And PG treatments have always been ineffective.
ADHD
Yeah, this is Alzheimer’s. Alzheimer’s in children.
- Patients with Alzheimer’s have a high frequency of previous ADHD symptoms.
- Alzheimer’s experimental mice have ADHD symptoms when young.
- Children and adolescents with ADHD had more gingival bleeding than their non-ADHD peers, but no difference regarding plaque or gingivitis was detected between groups.
The vampire at work.
This is a sign of early infection.
The bacteria extracting the blood.
Migraines/Cluster Headaches
PG is capable of infiltration and survival in the Trigeminal
nerve, the largest nerve in the face. It
parties in there with the Herpes 1 virus.
They are both capable of traveling back to the brain from the mouth.
They also both invade the Facial nerve. If you look at the maps of these nerves,
you will see why we have headaches. They
wind everywhere including most of the sense organs. The inflammation clenches our heads.
Trigeminal Nerve Facial Nerve
Brain Fog
This actually is in the brain. PG causes the activation of Astrocytes. Astrocytes are the cells in the brain that
physically surround, feed and maintain the nerve cells. There are more of them than neurons. Activation means their defense system is
activated, not the cell. They are
actually less functional. Their
filaments get stiff and membrane pores tighten.
Molecules don’t move as well.
They minimize maintenance of the nerve connections. If this goes on for too long, the neurons
they maintain will start to deteriorate.
Everyone assumes the death of the neurons cause the memory
problems. Maybe in the end, but this phenomenon is
problematic all along.
I believe this because I don’t have random gaps in my
memory. It’s all there, it just gets
dense and dark and too difficult and slow to navigate, and after the anxiety
gets bad, I just don’t bother. It
happens all over, more like a dimmer. The
details go first- proper names and intricate sequences.
It’s reversible too.
You have experienced this after illness. Most infections have this effect. When they resolve, your astrocytes relax and
your brain starts working again.
Self-Harm
This also seems like a direct consequence of pain suppression. These people are trying to ease their symptoms somehow. Punching things percusses the shoulders and spine. Pounding your head vibrates the sinuses and spine. Running probably works too. Piercing your face and ears suppresses the trigeminal and activates the vagus nerves. Cutting your skin activates your epithelial immune system- this includes tattoos and repetitive elective surgery. If you can withstand tattooing your face- you can feel no pain. Clean your teeth instead.
PTSD
I am pretty sure this is caused by dental neglect. I have yet to think of a life trauma that
doesn’t involve ignoring the dentist and/or brushing your teeth. This is especially true in accidents or
illnesses requiring surgery or rehabilitation.
That is the wrong time to forget about your mouth. If this infection is acute, you will not be
able to incorporate a lot of change in your life. Your brain can’t remodel the nerve
connections. You will have a lot of
anxiety and go over the same old thoughts.
Your senses will be all messed up. You won’t be able to sleep
properly.
Narcolepsy
I have been doing involuntary field research on this
condition my whole life. It is easily
inducible with chronic illness. Bacteria
in your bloodstream lowers orexin levels.
Sleeping is sickness behavior.
This is a fun find for me. This gene is highly associated with
Narcolepsy:
The DQB1*0602 gene may produce an accelerated immune
response to certain periodontal bacteria such as P. gingivalis and thus
increased susceptibility to early onset periodontitis.
Yeah, that makes total sense.. I went to conferences, all the narcos seemed
to have problematic teeth. I was so
sure it was related, I handed out toothbrushes one year. Sadly, brushing didn’t help. Gluten-free diets did though… for a while.
Sleepwalking, Cataplexy, Tourette’s Syndrome
These behaviors are caused by chronic inflammation of the
throat and neck. It pinches major
nerves and causes all kinds of sudden involuntary behavior.
I have written another page about that. It’s too long for this discussion. The point is- all these infections cause
inflammation in the mouth, throat and neck.
Having them at the same time can short-circuit your head from your body.
Schizophrenia
These people have a bunch of the other symptoms, and hallucinations too. The hallucinations are caused by those inflamed and pinched nerves all over their face.
Lots of eye nerves get irritated, there’s a big junction
behind your eyeballs. I don’t really
see things when my eyes are open, but I do have a lot of shapes and shadows and
movement when they are closed.
Geometric patterns when I fall asleep.
Lots of radial symmetry. All
that seems to come from socket infection of the upper teeth, it changes
depending on which teeth are problematic.
There’s motion too, which makes the ray pattern look like a tunnel. The motion seems to come from the trigeminal nerve. It pulsates and creates ripple patterns from the center, like a pebble dropped in water. (Epilepsy trigger alert!) The overlapping patterns simulate forward propulsion somehow. This morphs into driving in my dreams. There is usually a sudden cliff at the end of the road. The pattern is usually black and tan, but became a 3-D multicolor chrysanthemum firework when I was my sickest.
I never really had intrusive voice hallucinations, but I
can imagine. All the nerves for hearing
meet at the jaw hinge, and there’s always a lot of infection by the
molars. There are many phrases that repeat in my mind,
but I don’t hear them. I say them out
loud instead. It’s delightful. I think
the angry ones come from the Habenula (next section).
I do have diminished and distorted hearing since my lower
molars broke, though. Constant high-frequency
low-intensity ringing. If I sit under a
loud fan, it sounds like whispering. My
windshield wiper motor sounds like a siren.
I get sudden high-pitched tinnitus if my nostrils dry out. It sounds a lot like a woman shrieking. I have a terrible time changing altitude
anymore, too.
I am quite sure anyone with infected and impacted molars is
susceptible to this phenomenon.
Suicide
This microbe highly activates the Habenula in the
brain. The habenula causes panic attacks
and major depressive disorder. Avoidance
behavior. Fleeing from aversive stimuli.
That part of the brain tells you if it thinks your
decisions are wrong. An overactive
habenula makes you think your decisions are always wrong. Your behavior is wrong. Everything you do is wrong. Everything you
ever have done is wrong. Everything you
ever will do will be wrong. Acute
dysfunction creates the feeling of absolute futility and is the source of
suicidality.
Yeah, been there, done that. My entire life. It really makes being told you’ve made a mistake an excruciating experience. It makes you hate and avoid authority. You blame them for causing your pain.
It’s almost impossible to admit a mistake. It feels like the end of the world. We’ll do anything to avoid it.
That explains a whole lot of things I see every day.
Addiction - The Phantom Menace
I don’t really believe in addiction.
This concept was
invented when social workers couldn’t figure out how to get people to stop
taking drugs. Drug cessation programs
were supposed to solve everything.
Rehab doesn’t work. Everyone relapses. There’s a reason. Getting sober does not solve the problem!
“Addiction
Experts” assert that drug seeking behavior is caused by the drugs. Yeah, No.
The
“recreational” and “abuse” drugs are therapeutic. They ease pain. They calm the mind. They increase stamina. They address the crippling symptoms of
chronic illness. Many of them are
antimicrobial, and a lot started as pharmaceutical medications.
They don’t solve
the problem, but they do ease suffering.
The issue isn’t that they are partially effective, but that they also
have destructive long-term effects.
Until now, their long-term consequences really have been worth the risk-
because doctors didn’t help.
They tell us
we’re imagining our symptoms. They document
that we are incompetent and/or anti-compliant. They make our problems worse with these
labels. And then they give us drugs that aren’t
effective either.
We don’t take drugs because we are stupid. People are really not that stupid. We take them because they make us feel better. We’re sick.
Frankly, we’ve
done a better job of suppressing P. gingivalis than they have.
Don’t want to believe that? Let me elaborate on some of the therapeutic reasons to use the chemicals classified as recreational drugs or drugs of abuse:
Alcohol- The reason people drink is because it
reduces pain and makes them forget their problems. It’s very pleasant. All primates love it and seek it out. Humans
invented agriculture to make more of it.
It’s not that toxic
by itself, but it is truly problematic for people with active P. gingivalis
infection (at least half of humanity).
Ethanol has slight inhibitory effects on PG when it is free but has no effect when it is embedded in its periodontal biofilms. It doesn’t seem to make it grow more or less. Alcohol dries out the mouth though, and when saliva flow is reduced, the risk for tooth decay and gum disease increases. It also increases epithelial permeability in the mouth and the intestines. That allows transfer of microbes and vessicles into the tissues of the head and body.
The real problem with alcohol is it triggers the digestive tract cancers. P. gingivalis is capable of converting ethanol into acetaldehyde, which is a carcinogen. Alcohol use with PG is highly associated with that whole series of cancers.
Please don’t drink to drown the depression, it doesn’t work. Low level drinking in healthy people activates the habenula to make you stop. After a lot of drinking, the cessation circuit wears out, so you keep seeking. Your habenula is on fire from the PG, you feel like you’re going to die, and you don’t want to stop drinking…
You’ll stop
sometime anyway. Alcohol increases
intestinal permeability in addition to the germs and the gluten. Your guts will eventually give out. That’s not a fun day or three. You’ll never drink again after that. Try marijuana if it’s legal. It works way better.
Opioids.
These are pretty easy to explain.
People with progressive arthritis and gut damage will be attracted to
them. They will become dependent on
them. Because they stop the pain. The pain in their guts and spines. The pain their doctors say doesn’t
exist. The problem with opioids is they
progressively disable the opioid receptors, making the drugs less effective
over time. People aren’t addicted, their
relief is diminishing AND they are getting sicker! They need an effective therapy! It’s not a mystery why people are
overdosing on Fentanyl. They are
desperate.
Nicotine inhibits
herpes virus replication. It impairs P.
gingivalis infiltration into cells. It
lessens inflammation. It improves the
symptoms of Parkinson’s. It slows the
progression of Alzheimer’s.
It suppresses
the Habenula!!!!!
This is surely the reason I couldn’t quit smoking.
Because when I did, my brain became worthless. This is probably the reason 20%
of the population still uses nicotine despite billions of dollars spent on
cessation programs. I switched to vaping
10 years ago. I think it saved my
life. In many ways.
Nicotine is not carcinogenic. All the other stuff from burning cigarettes
is toxic. Destroys your gum integrity.
Marijuana improves intestinal integrity and
effectively soothes spastic nerves. It
calms the tremors of Parkinson’s Disease.
It made it possible for me to work during severe Tourette’s. It messes up my memory, but not nearly as
bad as brain infection does. It’s been
truly therapeutic.
Cocaine administered nasally alleviates sinus
congestion. That was its first medical use.
It also kills P. gingivalis when applied to the gums. That probably explains the crack epidemic
right there. High potency antimicrobial
action delivered directly to the oral tissues.
Amphetamines- have always been used to reduce
nasal inflammation. They also induce
ketosis which stimulates the immune system and alleviates exhaustion. They dry out your gums and salivary glands
though, and promote periodontal disease.
This is why meth addicts’ teeth fall out.
This is especially problematic because gum disease can cause narcolepsy and amphetamines are the first treatment prescribed for people with that. Yeah, I’m not kidding. I lost two teeth.
Do you see the pattern? A lot of these are ingested through the mouth. Or they affect the nerves in the mouth and head and guts. That’s a big red flag with a cherry on top, people.
Taking drugs is not a brain problem, it’s a desperate mouth solution.
I have never met a drug addict or crazy person who had
good teeth. Health care providers consistently get this causation
backwards. The dental pathology
actually comes first.
The only reason I didn’t go to jail for drugs is because
I’m a privileged white woman. A
librarian. Nobody ever checked my purse.
We experiment for fun, and figure out that we’ve been lied to. They don’t make us feel bad at all. Some of them really help a lot. They just don’t solve the problem.
Think Rationally- Choose the Yellow Powder
Plaque begins to show up in archeological remains shortly before the time that agriculture starts.
Human health took a dramatic turn for the worse after
agriculture was established.
Teeth scraping was a prehistoric occupation, wooden picks
must have been used. Tooth scrapers are
some of the first metal implements, and tooth picks and brushing sticks are
used even today.
Abrasive tooth pastes and powders were used in ancient
civilizations. Dental procedures were
common.
The first thing to do if you have these diseases in your
family, or symptoms of your own:
Get a DNA test for APOE status. You need to know if you inherited the APOE4
gene.
HSV1 is as common as PG.
Almost everyone has been exposed to it by the time they are 40.
If you are APOE4 positive and have had recurrent oral
Herpes virus lesions
Get a permanent preventative prescription for
Valacyclovir. Seriously, demand
it. Your brain is at high risk of
infiltration.
Try nicotine lozenges or gum during an outbreak if you
can’t get a prescription. Take a
picture of the lesion and order online.
Elevated salivary APOE levels are indicative of a
bacterial infection in children. This
can also be tested.
All of these microbes are easily tested with a swab or
spit test. Ask to be tested if you have
oral sores or gingivitis. Flossing is
not going to help if you have a pathological biofilm.
You must get your broken teeth and cavities fixed. Rotten ones need to be pulled. No, it’s not better to keep them in your
head. One deep infection will affect
your whole mouth and head and ability to heal. The germs are constantly flowing into your
bloodstream.
When doctors say Oral Administration of a drug, it isn’t
really. They give us pills. Red pills, blue pills.
That is post-gastric systemic administration. That is the reason their treatments are so
ineffective when tested on these problems.
What we need is topical oral administration.
The basic rule for the rest of the therapies is APPLY TO
THE ORAL TISSUES. Find ways to
distribute the treatments around your mouth.
Streptococcus bacteria
Strep species are the “foundation” microbes in
periodontal disease- the “gateway microbes” to insanity. They usually infect the mouth and throat
area in children. They tear up the
tissues and allow all the other microbes to move in. This includes Strep mutans which causes
cavities and Strep viridans which infects the tonsils. Those are usually transient, but they
facilitate the permanent colonization of Strep pneumoniae in the nasal sinuses,
and PG and herpes in the mouth.
Strep bacteria are highly resistant to antibiotics anymore. Baking soda is the preferred treatment. In toothpaste or mouthwash or nasal spray. It’s mildly abrasive and alters the pH level and they can’t metabolize sugar. It works really well.
P. gingivalis
If you have tartar buildup and periodontal disease, dentists will scrape the hell out of your teeth and give you Chlorhexidine rinse. This is maybe not the most appropriate approach. Vigorous scraping cuts the gums and allows the microbes to infiltrate. P. gingivalis vessicles disable chlorhexidine. PG biofilms survive chlorhexidine treatment. The rapid reduction in plaque bacteria also seems to result in an increase in strep mutans bacteria after therapy.
My mouth was so insensate and my narcolepsy so bad, I did this without anesthetics and slept through most of it. That did not seem to concern the dentist or hygienist in any way.
PG also makes chemicals that neutralize hydrogen peroxide. Theoretically, it should work since it’s an anaerobic bacterium, but it really doesn’t.
Since those aren't effective, they might give you
antibiotics.
There are not many antibiotics that work on this
menace. It apparently collects
resistance genes really easily.
Right now, the recommended one is Moxifloxacin. It works pretty well to alleviate symptoms in
patients, but it has been shown that PG inside the cells can survive. The current consensus is that the elimination
of intracellular PG by systemic antibiotics alone is problematic. The
indiscriminate use of antimicrobials for PG could result in the appearance of
more highly resistant strains of this and other bacteria associated with
periodontal diseases.
I will not take any more systemic antibiotics. The last one nearly killed me.
Statin drugs- which are prescribed for atherosclerosis, efficiently inhibit P. gingivalis and have also been shown to regrow bone in the jaw! They are not enough though.
Here are the things I have found that are inexpensive,
available publicly, work really well, and might be enjoyable.
Compact
Interspace Toothbrush- you need a
small brush to get behind and between teeth.
This is not possible with a large brush and you leave spots
unattended. Also called a denture, orthodontia,
or end tuft brush.
Mouth mirror
with light- I’ve seen them at most
pharmacies.
Sonic tooth
scrapers- (notes and pics in
references)
You must clean
the plaque and tartar off your teeth.
It’s toxic. It’s rough and
collects debris. It forms biofilms with
other nasty microbes. Brushing and
flossing is not effective enough to prevent tartar under the gumline.
I thought this
machine would be a scam. I have owned
every kind of Waterpik over my lifetime, they are useless. They wash right over
stuck on plaque. These sonic tooth
scrapers are amazing. They feel like a
massage when you’re doing it and give you that relaxed head feeling when you’re
done
These first four items are always on top of all the lists
of substances tested:
Curcumin/Turmeric.
This is a bright yellow spice originally from India. It has been used there for centuries to
combat gum disease. It’s highly
effective against PG. More effective
than the recommended antibiotic. It has two names; Turmeric is the plant,
curcumin is the spice. You will see either name on the products.
You can cook just about anything with it. You can make tea. You can put it in smoothies. It comes in candy and gummy form. I like the gummies. Gummies are my favorite
food group. I have been wishing for gummy candy that heals my mouth for a very
long time.
Put it in your mouth twice a day. Try to keep it there as long as possible. Ginger is related and seems to help too.
Quercetin-
also shown to be highly effective.
Available in all the forms already mentioned.
Green Tea- very effective against PG and reduces
mouth inflammation drastically. I drink
white tea, which is the younger leaves of the same tree. Works in minutes. Do not mix with curcumin, they don’t work
well together.
Chamomile Tea-
same as above.
Capsaicin- Oh this deserves a whole section. It’s fascinating. Capsaicin is the molecule that makes chili
peppers spicy. They activate the capsaicin
receptor in your mouth and it feels hot.
The thing about it is, after a number of stimuli, it stops working and
your sensory nerve endings are disabled for a while. That’s why you boys think
it’s impressive to eat it as sport. Men
with no pain sensation like to injure themselves for attention.
This is the same receptor PG uses to attach to your
gums. Chili capsaicin will fill up the
receptors so PG can’t attach.
Temporarily.
I am pretty sure that a lot of hot sauce addicts are
using it for a reason. It’s a symptom.
The capsaicin in food won’t normally hurt you, but all
that vinegar and sugar you put it in isn’t so great for your mouth. Acid
facilitates the growth of adverse strep bacteria. Capsaicin should be mixed with fatty
substances. You don’t need a lot,
there’s a limit to how much is effective.
Extreme is unnecessary and just ridiculous.
Aloe Vera-
disrupts biofilm formation. It
comes in juice, and gel and toothpaste.
Cocoa Yes
chocolate. It’s the polyphenols. It also reduces pain. I think this is why chili chocolate is so
popular.
Vitamin C also
reduces inflammation and strengthens the cell membranes against invasion. It has been shown to improve
periodontitis. Comes in all kinds of mouth
coating versions.
Probiotics Some species of bacteria in the mouth can obstruct the attachment of PG. Here are a few I found in research along the way. There are probiotic gummies now, but I didn’t read the labels.
- Yogurt
- Lactobacillus rhamnosus
- Lactobacillus reuteri
- Lactobacillus pentosus
- Bifidobacterium bifidum
- Streptococcus gordonii
The fact that intracellular PG is so resistant to
treatment is a real problem.
I don’t know if it will ever be totally eradicable in colonized patients. I do think the tumors will be way more survivable. As long as these superficial options are our only choice, we will have to be diligent in our mouth maintenance.
My experience has been: reducing the bacterial burden in
the mouth and by extension the digestive tract, helps a lot. My dry sockets and deep pockets have finally
healed. It has relieved the mental
symptoms remarkably. I don’t think
it’s regrowing any of my brain cells. I
don’t know if it will allow pancreatic beta cells to regenerate. But I believe I have proven I can think
again. I’m not having constant panic
attacks. I am not bent over in pain with
arthritis or Tourette’s anymore.
Here are a couple of things that are worth mentioning.
Don’t kiss random people. PG and HSV1 are highly contagious. Cavities are too! You definitely don’t want all these infections at the same time. You also don’t want to give them to others.
Vitamin B12
accelerates the growth of Porphyromonas gingivalis. If you are actively trying to get rid of
PG, you probably shouldn’t take B12.
PG eats amino acids; it likes to feed on meat. A lot of us have adopted low carb diets to compensate for the insulin resistance. We have to be extra careful about removing the all the protein debris from our teeth and gums. Maybe even our guts for a while. This may be the reason for the conflicting reports on the dangers of eating meat. Maybe it’s not the meat that’s dangerous.
High glucose availability increases the inflammatory response induced
by PG.
Toxoplasma
gondii parasites live in cats. They live
in cat feces. You can get it in your
brain if you are around cats or cat waste.
It causes cognitive problems of its own and it will accelerate
Alzheimer’s pathology.
COVID is still everywhere. Get your vaccines! Wear your masks!!!
Coming technology:
VACCINES!!!!
Gingipain R1 is
the attachment molecule for PG. An
experimental R1 DNA vaccine induced specific antibodies against this molecule, and
this vaccine protected against P. gingivalis invasion in mice.
This is
different than the vaccines that were supposed to clear out excess Beta
Amyloid. These antibodies keep the
bacteria from attaching and infecting in the first place.
I think the antivaxxers might need them the most…
------------------------------------------------
The End of the World as We Know It- and I feel fine
It looks like all of civilization has been plagued by
this problem. Most of humanity still
is.
All of modern society seems to be built around mitigating the effects of this tiny microbe. It’s breathtaking.
Most of history is a long series of blaming these
perpetual problems on someone else.
Everyone else.
But it’s not them.
It’s all of us.
These Microbes Make Humans Sick and Crazy. And they are everywhere. It’s pretty much as simple as that.
MEDICAL
Hey Doctors. Y’all need to look in our mouths. You need dentists and periodontists in the places where you “practice” medicine. And you need to check eachother’s work. The simple act of brushing hospital patients’ teeth prevents pneumonia and sepsis. This is noteworthy to us patients, as those are the two most deadly, and most profitable complications of this infection…
You have made more than enough money off our complications, thank you very much. Buckle up, your days of running the asylum are over.
The fact that this one microbe causes so much damage should not have escaped attention for so long. The separation of medical, dental, mental and vision care has left a whole lot of blind spots in your knowledge base and ability to discern patterns.
This concept of teeth causing mental problems has been around for millennia. Both Dentists and Doctors dismissed and ridiculed and ignored it. The concept of painless dental infecton is also well documented. Both these ideas were common 100 years ago.
The advanced research is not exactly new either. The gingipain vaccines were tested in 2001. There is a patent for intranasal administration of Curcumin for Alzheimer’s from 2006. It is absolutely unacceptable that none of you know about this.
Just to be clear- I have had narcolepsy since 1965. Intermittent dementia for over 20 years. Severe symptoms for 10 years. I have been unable to shop for groceries for five years. After healing my mouth for two months, I smoked over an ounce of high grade sativa while wrting this paper . It took me three weeks. THIS IS NOT A MYSTERY. You will get no mercy from me.
Now, you all need to create some protocols to check yourselves as you go forward.
The pathology always, always, always comes first.
Don’t make the same assumptions you have made before. People are not stupid. People do not want to be depressed or fat or crazy. And there are really good reasons why we are afraid of you. You disavow your responsibility and send us to Psychs.
Yeah Psychs- This has been right in front of your faces. Under your own noses. You never even came close to getting it right. You must immediately stop promulgating your unmitigated patient-blaming nonsense. I never want to hear about hypochondria or hysteria ever again. Those are disdainful diagnoses you made up rather than admit your ignorance. There will be no more sobriety clinics, no more cognitive or Freudian therapy. Refer all your patients to a dentist. You may redeem yourselves by cleaning teeth in mental and memory institutions.
- I saw an article suggesting that PG LPS could be used for pain relief. NO! DON’T DO THAT!!!!!!
- Beta-Lactam antibiotics burst these bacteria all over the body and induce sepsis. Yeah, it took my brain five years to recover from that. Doing research with amnesia…
- Your cholesterol-testing-based mega-billion dollar revenue stream has to go. That has always been a scam.
- Make Valacyclovir available over the counter in the U.S. - like the rest of the planet.
- I hope you can now see that all your immune system suppressing drugs are not a good idea. If infections are a complication of your drug, you're making this, so basically everything, worse.
People need more tailored dental information and
treatment:
The symptoms of P. gingivalis differ based on the amount
of melanin in the skin. Dark pigmented mouths
do not produce as much inflammation as non-pigmented. The infection is less noticeable and
peripheral damage progresses further before treatment. This is a real simple fact that introduces
racial bias into your diagnoses and ruins a whole bunch of lives.
- Race and sex differences also exist in the shape of the face and the structure of the teeth. This determines tooth durability and susceptibility to cavities.
- Small jaws and tooth crowding is more common in western European populations. So is Alzheimer’s.
- Cranial differences result in variations in nerve impairment and mental symptoms during inflammation.
Crowded and crooked teeth are a problem. They facilitate plaque buildup in tight
crevices and chewing forces cause bone and nerve problems at the roots. Those of us with tiny mouths need teeth
removed. Almost everyone needs their
wisdom teeth removed.
Orthodontia is also a problem, of course. The brackets and wires tear up the tissues of
the cheeks and tongue, allowing infection there. All the tension on the teeth causes gaps at
the gumline, damage to the bone, and infection in the sockets. Retraction of the upper incisors causes pain,
breathing problems and a seriously bad attitude. This tortuous
procedure derailed my life.
I have never been referred to a periodontist. I had teeth extracted, deep purulent pockets and was told to floss more. I have never been tested for infection by a dentist.
Cosmetic dentistry.
Ooh here’s a real problem.
The infection rate on those procedures is alarmingly high. 30-40% !!! You have been putting veneers and implants in
highly toxic environments. I have been
watching some very famous people’s faces get bumpy and their brains melt down
after their teeth have been “fixed”.
This is not an acceptable paradigm: Ignoring our infections until our teeth are
rotten. Giving us prosthetics without
resolving infection. Removing teeth. Installing
dentures.
This also goes for elective surgery. Especially on the face. It seems to be addictive (ineffective).
Prove Botox is effective for depression. I see no evidence. It merely paralyzes infected nerves.
Lidocaine does seem to kill the oral cancers. All the oral x-caine anesthetics inhibit P. gingivalis.
Hey, it looks like having a bunch of holes in your mouth
and preexisting illness allows COVID to roam wild and light fires all over the
body.
- The COVID- Periodontitis study found that COVID-19 patients with gum disease 9 times more likely to die, and also that those with gum disease were 3.5 times more likely to be admitted to intensive care and 4.5 times more likely to need a ventilator.
- Other studies showed poor oral health has a direct connection to increased COVID-19 infection and to a higher risk of severe illness in patients with COVID-19.
- Levels of white blood cells, C reactive protein, and D-dimer (indicative of blood clotting) were also significantly higher in the blood of COVID-19 subjects with periodontitis.
All these things and surely more need to be taken into
account with testing and treatment options.
LEGAL
Yo lawyers. Get your guns and money.…
Yeah, Prison. This
is men’s solution to the problems they cause.
The warehouse of pain insensitive people- being confined by other pain insensitive
people. It’s an easy and effective way to isolate the aggressive, I guess. People who can’t feel pain enjoy being
cruel. It’s pretty obvious it doesn’t
really solve anything though. And never
has.
There are lots of infected brains occupying the penal
colonies.
There always has been.
Lock them up. Drug them. That
is the appalling history of mental health care.
There are still mentally ill people being chained to posts all over the
world. People who are missing a lot of
teeth.
You cannot hurt people who have no skin sensation. Whose habenulas are on fire. This is why torture doesn’t work. Deprivation doesn’t work. It increases the pathology and desire to flee. Without that ability, retaliation is the only choice.
This is the “cycle” that needs breaking.
It must stop. If
the government is going to take away someone’s liberty, they must provide
resources to alleviate and prevent these debilitating outcomes. The current system considers non-compliant
behavior to be a reason to not provide those things (nicotine, electric
toothbrushes) to prisoners. Of course.
I don’t have enough time left in my life to examine this
issue properly. I really don’t want to
think about it. The consequences are
just endless. Children of incarcerated
parents have significantly worse oral health.
Go figure. I can think of three
reasons instantly.
It’s monumentally depressing to me. There are lots of you who have been working in
social justice and public health for a long time. You people need to think hard and work fast.
Oral health is the true measure of a just society.
I’m hoping there is some kind of Truth and Reconciliation
commission that could process prisoners who effectively manage their infectious
burdens and improve.
Yeah, until this
problem is solved, we need age limits for politicians. I’m serious. We have a lot of important things to do. Cognitively fossilized people are a hazard to
our survival. The healthy ones don’t
compensate for the useless ones.
In the meantime,
this is a problem government can address.
MUST address.
The evolution of
humans has provided us with teeth that don’t fit in our flat faces
properly. Everyone will need to have a
major procedure at some time.
Capitalism has
created a dental care system that is inaccessible to the people who need it
most. People who really don’t want to
be a problem. People who need medical
and mental health care. Because they
didn’t get dental care. Because they
couldn’t afford dental care. It’s catastrophic
in its effect.
If we prevent
this one microbe, we can cut the health care costs of everyone. Promote the general welfare of the entire
human race.
And maybe we can
stop arguing and buy electric cars and solar panels and rescue the planet…
------------------------------------------------
We now have the ability to truly understand
our world and make it a more predictable place.
To not be afraid of whole groups of people
and recognize real danger.
To truly forgive our neighbors and actually
help those who are suffering.
This is a great moment to be alive.
