kitchen table hypotheses: Bibliography

Bibliography

I have shown the links for access by text-only readers.

Alzheimer’s Disease

Pathogens associated with AD
Viruses	Bacteria	Fungal	Protozoa
Human herpesvirus 1 (HHV-1)	Chlamydia pneumoniae	Candida albicans	Toxoplasma gondii
Human herpesvirus 2 (HHV-2)	Helicobacter pylori
Cytomegalovirus (CMV/HHV-3)	Borelia burgdorferi
Epstein-Barr virus (EBV, HHV-4)	Treponema pallidum
Varicella-zoster virus (VZV, HHV-5)	Porphyromonas gingivalis
Human herpesvirus 6 (HHV-6)	Fusobacterium nucleatum
Hepatitis C virus (HCV)	Prevotella and other periodontal bacteria

Source: https://www.xiahepublishing.com/2572-5505/JERP-2021-00030

Porphyromonas gingivalis bacteria and Herpes viruses are found in Alzheimer’s disease brains

https://www.science.org/doi/10.1126/sciadv.aau3333

Porphyromonas gingivalis is a Strong Risk Factor for Alzheimer’s Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835991/

Alzheimer’s Disease-like neurodegeneration in porphyromonas gingivalis infected neurons with persistent expression of active gingipains.

https://pubmed.ncbi.nlm.nih.gov/32390638/

Porphyromonas gingivalis, a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice

https://pubmed.ncbi.nlm.nih.gov/29422938/

Porphyromonas gingivalis-induced periodontitis could contribute to cognitive impairment in Sprague–Dawley rats

https://pubmed.ncbi.nlm.nih.gov/37056710/

Porphyromonas gingivalis in Alzheimer’s disease brains

https://pubmed.ncbi.nlm.nih.gov/30746447/

Porphyromonas gingivalis Infection Induces Amyloid- Accumulation in Monocytes/Macrophages

https://pubmed.ncbi.nlm.nih.gov/31594220/

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

https://pubmed.ncbi.nlm.nih.gov/30746447/

Alzheimer's disease-specific tau phosphorylation is induced by herpes simplex virus type 1

https://pubmed.ncbi.nlm.nih.gov/19221424/

Simultaneous VZV and HSV-1 Reactivation after Minor Head Injury

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727618/

Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway

https://pubmed.ncbi.nlm.nih.gov/36631446/

Seropositivity and reactivations of HSV-1, but not of HSV-2 nor VZV, associate with altered blood-brain barrier, beta amyloid, and tau proteins in people living with HIV

https://pubmed.ncbi.nlm.nih.gov/36352195/

Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159731/

APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-kB activation

https://pubmed.ncbi.nlm.nih.gov/35977506/

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831066/

β-Amyloid peptides display protective activity against the human Alzheimer's disease-associated herpes simplex virus-1.

https://pubmed.ncbi.nlm.nih.gov/25376108/

Anti-Viral Properties of Amyloid-β Peptides.

https://pubmed.ncbi.nlm.nih.gov/27392871/

Viral Involvement in Alzheimer’s Disease

https://pubs.acs.org/doi/10.1021/acschemneuro.0c00719

The herpesvirus–Porphyromonas gingivalis–periodontitis axis

https://onlinelibrary.wiley.com/doi/abs/10.1034/j.1600-0765.2003.00659.x

Herpesviral–bacterial interrelationships in aggressive periodontitis

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0765.2004.00728.x

Antivirals Reduce the Formation of Key Alzheimer's Disease Molecules in Cell Cultures Acutely Infected with Herpes Simplex Virus Type 1

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025152

Insights of Valacyclovir in Treatment of Alzheimer's Disease: Computational Docking Studies and Scopolamine Rat Model

https://pubmed.ncbi.nlm.nih.gov/36089794/

VALZ-Pilot: High-dose valacyclovir treatment in patients with early-stage Alzheimer’s disease

https://www.diva-portal.org/smash/get/diva2:1727274/FULLTEXT01.pdf

Effect of curcumin on growth, biofilm formation and virulence factor gene expression of Porphyromonas gingivalis

https://pubmed.ncbi.nlm.nih.gov/32279229/

-------------------------------------------------

P. Gingivalis the vampire squid

Porphyromonas gingivalis and Its Systemic Impact: Current Status

https://www.mdpi.com/2076-0817/9/11/944#B1-pathogens-09-00944

Porphyromonas gingivalis survives within KB cells and modulates inflammatory response

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-302X.2006.00282.x

Intercellular Spreading of Porphyromonas gingivalis Infection in Primary Gingival Epithelial Cells

https://journals.asm.org/doi/full/10.1128/iai.74.1.703-710.2006

Porphyromonas gingivalis survives within KB cells and modulates inflammatory response

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1399-302X.2006.00282.x

The Atherogenic Bacterium Porphyromonas gingivalis Evades Circulating Phagocytes by Adhering to Erythrocytes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067526/

Translocation of Porphyromonas gingivalis infected monocytes and associated cellular responses

https://pubmed.ncbi.nlm.nih.gov/21038790/

Stimulatory Effects of Glucose and Porphyromonas gingivalis Lipopolysaccharide on the Secretion of Inflammatory Mediators From Human Macrophages

https://aap.onlinelibrary.wiley.com/doi/abs/10.1902/jop.2013.130009

Biological activities of surface-associated material from Porphyromonas gingivalis

https://academic.oup.com/femspd/article/6/2-3/147/440848

ATHEROSCLEROSIS

Infection of Porphyromonas gingivalis Increases Phosphate-Induced Calcification of Vascular Smooth Muscle Cells

https://www.mdpi.com/2073-4409/9/12/2694

The role of Porphyromonas gingivalis gingipains in platelet activation and innate immune modulation

https://onlinelibrary.wiley.com/doi/abs/10.1111/omi.12067

Increased levels of Porphyromonas gingivalis are associated with ischemic and hemorrhagic cerebrovascular disease in humans

https://www.scielo.br/j/jaos/a/R4Qn6wxZdZRGD7TxtvXdWtq/?lang=en

Lipoprotein modifications by gingipains of Porphyromonas gingivalis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969291/

Chronic Oral Infection with Porphyromonas gingivalis Accelerates Atheroma Formation by Shifting the Lipid Profile

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020240#s2

Invasion of Porphyromonas gingivalis strains into vascular cells and tissue

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557090/

STROKE

Periodontitis and stroke

https://www.nel.edu/userfiles/articlesnew/NEL340313R03.pdf

Antibodies to Periodontal Pathogens and Stroke Risk

https://pubmed.ncbi.nlm.nih.gov/15232116/

Arterial thrombosis after intravenous infusion of oral bacterium in a rat model

https://pubmed.ncbi.nlm.nih.gov/18411025/

Systemic exposure to Porphyromonas gingivalis predicts incident stroke

https://www.sciencedirect.com/science/article/abs/pii/S002191500600387X

Serum IgG titers to periodontal pathogens predict 3-month outcome in ischemic stroke patients

https://www.sciencedirect.com/science/article/abs/pii/S1052305721007060

Gingipain R1 and Lipopolysaccharide From Porphyromonas gingivalis Have Major Effects on Blood Clot Morphology and Mechanics

https://pubmed.ncbi.nlm.nih.gov/32793214/

CANCER

Inhibition of epithelial cell apoptosis by Porphyromonas gingivalis

https://www.sciencedirect.com/science/article/abs/pii/S1075996415300652

Porphyromonas gingivalis Gingipains-Mediated Degradation of Plasminogen Activator Inhibitor-1 Leads to Delayed Wound Healing Responses in Human Endothelial Cells

https://karger.com/jin/article/14/4/306/824277/Porphyromonas-gingivalis-Gingipains-Mediated

Possible role of Porphyromonas gingivalis in orodigestive cancers

https://www.tandfonline.com/doi/full/10.1080/20002297.2018.1563410

Porphyromonas gingivalis and digestive system cancers

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473131/

The role of oral microbiota in cancer

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1253025/full

Frequencies of Porphyromonas gingivalis Detection in Oral-Digestive Tract Tumors

https://www.por-journal.com/articles/10.3389/pore.2021.628942/full

Association between Porphyromonas gingivalis and tumor-promoting status in esophageal squamous cell carcinoma

https://www.researchsquare.com/article/rs-22376/v1

Porphyromonas gingivalis: keeping the pathos out of the biont

https://www.tandfonline.com/doi/full/10.3402/jom.v5i0.19804

Potential role of epithelial–mesenchymal transition induced by periodontal pathogens in oral cancer

https://pubmed.ncbi.nlm.nih.gov/38031653/

Extracellular vesicles of P. gingivalis-infected macrophages induce lung injury

https://www.sciencedirect.com/science/article/pii/S0925443921001691

Clinical significance and prognostic value of Porphyromonas gingivalis infection in lung cancer

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718477/

Porphyromonas gingivalis enhances pneumococcal adhesion to human alveolar epithelial cells

https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.14084

DIABETES

Incretin Hormones and Type 2 Diabetes—Mechanistic Insights and Therapeutic Approaches

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766765/

Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses

https://www.frontiersin.org/articles/10.3389/fcimb.2023.1209381/full

Porphyromonas gingivalis impairs glucose uptake in skeletal muscle associated with altering gut microbiota

https://faseb.onlinelibrary.wiley.com/doi/ftr/10.1096/fj.202001158R

Protein implicated in tumor growth found to be heavily associated with pancreatic cancer

https://medicalxpress.com/news/2023-12-protein-implicated-tumor-growth-heavily.html

Intracellular Porphyromonas gingivalis Promotes the Tumorigenic Behavior of Pancreatic Carcinoma Cells

https://www.mdpi.com/2072-6694/12/8/2331

ARTHRITIS

Porphyromonas gingivalis and the pathogenesis of rheumatoid arthritis: analysis of various compartments including the synovial tissue

https://arthritis-research.biomedcentral.com/articles/10.1186/ar4243

The Relationship Between Porphyromonas Gingivalis and Rheumatoid Arthritis: A Meta-Analysis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340274/

P. gingivalis exacerbates arthritis via gut barrier dysfunction

https://www.nature.com/articles/s41584-019-0289-4

Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans

https://www.mdpi.com/2077-0383/8/9/1309

Porphyromonas gingivalis and rheumatoid arthritis

https://pubmed.ncbi.nlm.nih.gov/31268867/

Oral Anaerobic Bacteria in the Etiology of Ankylosing Spondylitis

https://journals.sagepub.com/doi/full/10.1177/1179544117712992

Periodontal Pathogens are Likely to be Responsible for the Development of Ankylosing Spondylitis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997922/

Periodontal diseases and its association with disease activity in ankylosing spondylitis/SpA: A systematic review

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9770410/

SALIVARY GLANDS

Polymicrobial infection alter inflammatory microRNA in rat salivary glands during periodontal disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775307/

Porphyromonas gingivalis lipopolysaccharide interferes with salivary mucin synthesis through inducible nitric oxide synthase activation by ERK and p38 kinase

https://pubmed.ncbi.nlm.nih.gov/12372406/

REPRODUCTIVE

Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers

https://pubmed.ncbi.nlm.nih.gov/34588004/

A potential therapeutic strategy for prostatic disease by targeting the oral microbiome.

https://onlinelibrary.wiley.com/doi/full/10.1002/med.21778 Well written, easy to understand.

Periodontitis in Pregnant Women: A Possible Link to Adverse Pregnancy Outcomes

https://www.mdpi.com/2227-9032/11/10/1372

Porphyromonas gingivalis and adverse pregnancy outcomes: a review on its intricate pathogenic mechanisms

https://pubmed.ncbi.nlm.nih.gov/32267781/

Estimation of Transmission of Porphyromonas Gingivalis from Mother to Child through Saliva

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827543/

Age and prevalence of Porphyromonas gingivalis in children.

https://pubmed.ncbi.nlm.nih.gov/8818903/

KIDNEY

Serum antibody to Porphyromonas gingivalis in chronic kidney disease

https://pubmed.ncbi.nlm.nih.gov/22828790/

Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238692/

CELIAC

Microbiome signatures of progression toward celiac disease onset in at-risk children in a longitudinal prospective cohort study

https://obj.umiacs.umd.edu/pnas-colwell/e2020322118.full.pdf

Characterization of Porphyromonas gingivalis-induced degradation of epithelial cell junctional complexes

https://pubmed.ncbi.nlm.nih.gov/10678958/

Salivary Gluten Degradation and Oral Microbial Profiles in Healthy Individuals and Celiac Disease Patients

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335528/

VISION

Periodontal Inflammation Linked to Vision Loss - Today's RDH

https://www.todaysrdh.com/periodontal-inflammation-linked-to-vision-loss/

Porphyromonas gingivalis outer membrane vesicles exacerbate retinal microvascular endothelial cell dysfunction in diabetic retinopathy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10213754/

Invasion of Human Retinal Pigment Epithelial Cells by Porphyromonas gingivalis leading to Vacuolar/Cytosolic localization and Autophagy dysfunction In-Vitro - PMC

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198524/

Exposure to Porphyromonas gingivalis and Modifiable Risk Factors Modulate Risk for Early Diabetic Retinopathy

https://tvst.arvojournals.org/article.aspx?articleid=2772282#

P. gingivalis the ghost in the machine

The paradox of painless periodontal disease

https://pubmed.ncbi.nlm.nih.gov/27397640/

The anti-nociceptive effects of Porphyromonas gingivalis lipopolysaccharide

https://www.sciencedirect.com/science/article/abs/pii/S0003996919300706

The Mysteries of Capsaicin-Sensitive Afferents

https://www.frontiersin.org/articles/10.3389/fphys.2020.554195/full

DEPRESSION

Porphyromonas gingivalis induces depression via downregulating p75NTR-mediated BDNF maturation in astrocytes

https://pubmed.ncbi.nlm.nih.gov/31299366

ProBDNF signaling is involved in periodontitis-induced depression-like behavior in mouse hippocampus

https://pubmed.ncbi.nlm.nih.gov/36738676/

Effects of Monoamines and Antidepressants on Astrocyte Physiology: Implications for Monoamine Hypothesis of Depression

https://journals.sagepub.com/doi/10.1177/1179069518789149

Inflammation-Induced Lethargy Is Mediated by Suppression of Orexin Neuron Activity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155688/

Scientists identify what makes us feel 'bad' when we're sick, how to treat it

https://www.sciencedaily.com/releases/2011/08/110803092314.htm

Lipopolysaccharide challenge-induced suppression of Fos in hypothalamic orexin neurons: their potential role in sickness behavior

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792632/

ANXIETY

Association of Stress, Salivary Cortisol, and Chronic Periodontitis: A Clinico-biochemical Study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169263/

Association of Porphyromonas gingivalis with high levels of stress-induced hormone cortisol in chronic periodontitis patients

https://www.biorxiv.org/content/10.1101/2020.08.09.243402v1.full

Circuits Regulating Pleasure and Happiness: The Evolution of the Amygdalar-Hippocampal-Habenular Connectivity in Vertebrates

https://www.frontiersin.org/articles/10.3389/fnins.2016.00539/full

BIPOLAR

Chronic Periodontitis Is Associated with the Risk of Bipolar Disorder: A Population-Based Cohort Study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277490/

HEADACHES

Porphyromonas gingivalis lipopolysaccharide rapidly activates trigeminal sensory neurons and may contribute to pulpal pain.

https://onlinelibrary.wiley.com/doi/full/10.1111/iej.13282

ADHD

Periodontal outcomes of children and adolescents with attention deficit hyperactivity disorder:

https://link.springer.com/article/10.1007/s40368-022-00732-8

Genetic risk for attention-deficit/hyperactivity disorder is associated with amyloid-dependent cognitive decline in older adults

https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.061603

Peridontitis as a Risk Factor for Attention Deficit Hyperactivity Disorder: Possible Neuro-inflammatory Mechanisms

https://link.springer.com/article/10.1007/s11064-022-03650-9

Alzheimer’s Model Develops Early ADHD Syndrome

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704098/

BRAIN FOG

Aberrant Calcium Signals in Reactive Astrocytes: A Key Process in Neurological Disorders

https://www.mdpi.com/1422-0067/20/4/996

New research shows astrocytes are key to swaying the pendulum in Alzheimer's disease progression

https://www.news-medical.net/news/20230529/New-research-shows-astrocytes-are-key-to-swaying-the-pendulum-in-Alzheimers-disease-progression.aspx

Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease.

https://pubmed.ncbi.nlm.nih.gov/37248300/

Accumulation of Aβ in astrocytes results in mitochondrial structural alterations.

https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-023-02722-z

Aβ accumulation in astrocytes caused significant deficits in maximal mitochondrial respiration and spare respiratory capacity despite no alterations on basal respiration or ATP production

Bonus article- The Other Half of the Brain- I read this article when it came out. It rearranged my circuitry. https://www.scientificamerican.com/article/the-other-half-of-the-bra/ (use stealth)

PTSD

Oral and Dental Considerations of Combat-Induced Post Traumatic Stress Disorder (PTSD)—A Cross-Sectional Study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181801/

Prevalence of post-traumatic stress disorder symptoms in adult critical care survivors: a systematic review and meta-analysis

https://ccforum.biomedcentral.com/articles/10.1186/s13054-019-2489-3#

NARCOLEPSY

Effects of inflammation produced by chronic lipopolysaccharide administration on the survival of hypocretin neurons and sleep

https://pubmed.ncbi.nlm.nih.gov/15306250/

HLA genetics for diagnosis of susceptibility to early-onset periodontitis

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0765.1999.tb02269.x

Immunoglobulin G subclass antibody profiles in Porphyromonas gingivalis-associated aggressive and chronic periodontitis patients

https://pubmed.ncbi.nlm.nih.gov/16922931/

SCHIZOPHRENIA

Viruses and schizophrenia: a focus on herpes simplex virus

https://pubmed.ncbi.nlm.nih.gov/15319094/

Association between schizophrenia and periodontal disease in relation to cortisol levels: an ELISA-based descriptive analysis

https://ejnpn.springeropen.com/articles/10.1186/s41983-021-00423-z

An oral pathogen and psychopathology severity in a sample of Arab patients with schizophrenia

https://journals.lww.com/mecpsychiatry/fulltext/2011/07000/an_oral_pathogen_and_psychopathology_severity_in_a.5.aspx

Interference waves simulation

https://www.ritsumei.ac.jp/~akitaoka/warp7.gif

Altered Volume and Functional Connectivity of the Habenula in Schizophrenia

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743681/

A botched root canal operation left a woman with hallucinations and migraines that she thought would kill her.

https://www.insider.com/woman-had-hallucination-and-migraines-due-to-botched-root-canal-2022-5

ADDICTION

Illegal drugs and periodontal conditions

https://onlinelibrary.wiley.com/doi/full/10.1111/prd.12450

ALCOHOL

Evaluation of the subgingival microbiota of alcoholic and non-alcoholic individuals

https://www.sciencedirect.com/science/article/pii/S0300571211001795

Ethanol Impairs Intestinal Barrier Function in Humans through Mitogen Activated Protein Kinase Signaling: A Combined In Vivo and In Vitro Approach

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165763/

The lateral habenula is not required for ethanol dependence-induced escalation of drinking

https://www.nature.com/articles/s41386-022-01357-7

OPIOIDS

Opioid receptor desensitization: mechanisms and its link to tolerance

https://www.frontiersin.org/articles/10.3389/fphar.2014.00280/full

Treating opioid disorder without meds is more harmful than no treatment at all, finds study

https://medicalxpress.com/news/2023-12-opioid-disorder-meds-treatment.html

NICOTINE

Suppression of overt gingival inflammation in tobacco smokers - clinical and mechanistic considerations

https://pubmed.ncbi.nlm.nih.gov/16451473/

The Role of the Habenula in Nicotine Addiction

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321348/

Nicotine produces selective degeneration in the medial habenula and fasciculus retroflexus

https://pubmed.ncbi.nlm.nih.gov/11430869/

Is vaping harmful?

https://www.cancerresearchuk.org/about-cancer/causes-of-cancer/smoking-and-cancer/is-vaping-harmful#

MARIJUANA

Efficacy of Cannabis-Based Medicines for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

https://pubmed.ncbi.nlm.nih.gov/28934780/

Cannabis in Parkinson’s Disease: The Patients’ View

https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd202260

Parkinson’s Foundation Consensus Statement on the Use of Medical Cannabis for Parkinson’s Disease

https://www.parkinson.org/sites/default/files/documents/medical_cannabis_statement_finalv2_5.pdf

TAA Position Statement on the Use of Medical Marijuana for Tourette Syndrome

https://tourette.org/research-medical/medical-marijuana/

COCAINE

Local anesthetics as antimicrobial agents: a review

https://pubmed.ncbi.nlm.nih.gov/18426354/

Comparison of 3% Mepivacaine and 2% Procaine in Local Anesthetics as Antibacterial Activity on the Growth of Porphyromonas Gingivalis

https://www.jidmr.com/journal/wp-content/uploads/2023/09/22-D23_2803_Vinna_Kurniawati_Sugiaman_Indonesia.pdf

Analysis of the antimicrobial activity of local anaesthetics used for dental analgesia

https://pubmed.ncbi.nlm.nih.gov/18065672/

The efficiency of topical anesthetics as antimicrobial agents: A review of use in dentistry

https://pubmed.ncbi.nlm.nih.gov/30186969/

Cocaine and lidocaine with phenylephrine as topical anesthetics: antimicrobial activity against common nasal pathogens

https://pubmed.ncbi.nlm.nih.gov/9693473/

These topical anesthetics have bactericidal activity against nasal pathogens, which can sometimes lead to false-negative results.

RT-PCR quantification of periodontal pathogens in crack users and non-users (The crack users should have much lower PG activity than healthy people…)

https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.12609

The antibacterial activity of topical anesthetics

https://pubmed.ncbi.nlm.nih.gov/9395876/

The Antimicrobial Susceptibility of Porphyromonas gingivalis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8698109/

AMPHETAMINES

Relationship between amphetamine ingestion and gingival enlargement

https://pubmed.ncbi.nlm.nih.gov/15460293/

Methamphetamine effects on blood-brain barrier structure and function

https://www.frontiersin.org/articles/10.3389/fnins.2015.00069/full

TREATMENTS

An estimated 3.7 billion people under age 50 (67%) globally have herpes simplex virus type 1 (HSV-1) infection, the main cause of oral herpes.

https://www.who.int/news-room/fact-sheets/detail/herpes-simplex-virus

Porphyromonas gingivalis: where do we stand in our battle against this oral pathogen?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8152699/

The additional value of real-time PCR in the quantitative detection of periodontal pathogens

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1600-051X.2006.00925.x

Elevated serum ApoE levels are associated with bacterial infections in pediatric patients

https://www.sciencedirect.com/science/article/pii/S1684118213000893

Effect of baking soda in dentifrices on plaque removal

https://pubmed.ncbi.nlm.nih.gov/29056188/

Sodium Bicarbonate A Review and its Uses in Dentistry

https://journals.lww.com/ijdr/fulltext/2018/29050/sodium_bicarbonate__a_review_and_its_uses_in.25.aspx

CHLORHEXIDINE

Porphyromonas gingivalis outer membrane vesicles promote bacterial resistance to chlorhexidine

https://pubmed.ncbi.nlm.nih.gov/8596676/

Porphyromonas gingivalis biofilms persist after chlorhexidine treatment

https://pubmed.ncbi.nlm.nih.gov/23659238/

Increase in cariogenic bacteria after initial periodontal therapy

https://pubmed.ncbi.nlm.nih.gov/15615875/

ANTIBIOTICS

Efficacy of Antibiotics Against Periodontopathogenic Bacteria Within Epithelial Cells: An In Vitro Study

https://pubmed.ncbi.nlm.nih.gov/15562909/

Emergence of Antibiotic-Resistant Porphyromonas gingivalis in United States Periodontitis Patients

https://www.mdpi.com/2079-6382/12/11/1584

Antibiotic resistance of subgingival species in chronic periodontitis patients

https://pubmed.ncbi.nlm.nih.gov/20546113/

STATINS

Determination of the antibacterial activity of simvastatin against periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans: An in vitro study

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147817/

The effect of statins on periodontal treatment-a systematic review with meta-analyses and meta-regression

https://pubmed.ncbi.nlm.nih.gov/29396642/

Efficacy of locally-delivered statins adjunct to non-surgical periodontal therapy for chronic periodontitis: a Bayesian network analysis

https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-019-0789-2

The effects of statins on dental and oral health: a review of preclinical and clinical studies

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132955/

CURCUMIN/TURMERIC

Effect of curcumin on growth, biofilm formation and virulence factor gene expression of Porphyromonas gingivalis

https://pubmed.ncbi.nlm.nih.gov/32279229/

Antibacterial Effect of Curcumin against Clinically Isolated Porphyromonas gingivalis and Connective Tissue Reactions to Curcumin Gel in the Subcutaneous Tissue of Rats

https://www.hindawi.com/journals/bmri/2019/6810936/

The Effects of Curcumin in the Treatment of Gingivitis: A Systematic Review of Clinical Trials

https://pubmed.ncbi.nlm.nih.gov/34331691/

Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241198/

The effect of curcumin as an adjunct in the treatment of chronic periodontitis: A systematic review and meta-analysis

https://www.sciencedirect.com/science/article/pii/S101390522100081X

OTHER TREATMENTS

Quercitrin for periodontal regeneration: effects on human gingival fibroblasts and mesenchymal stem cells

https://www.nature.com/articles/srep16593

Selected dietary (poly)phenols inhibit periodontal pathogen growth and biofilm formation

https://pubs.rsc.org/en/content/articlepdf/2015/fo/c4fo01087f

Effectiveness of Brewed Green Tea and Mouthwash Containing Green Tea Extract against Streptococcus mutans and Porphyromonas gingivalis in Saliva

https://www.researchgate.net/publication/346278453

Capsaicin inhibits Porphyromonas gingivalis growth, biofilm formation, gingivomucosal inflammatory cytokine secretion, and in vitro osteoclastogenesis

https://link.springer.com/article/10.1007/s10096-013-1947-0

Antibacterial Effects of Cocoa on Periodontal Pathogenic Bacteria

https://www.sciencedirect.com/science/article/abs/pii/S1349007910800337

Antibacterial Activity of Fermented and Non-Fermented Edel Cacao Bean Extract (Theobroma Cacao L.) Against Porphyromonas gingivalis

https://www.academia.edu/76524883/

Antibacterial Activity of Nanoparticles of Garlic (Allium sativum) Extract against Different Bacteria Such as Streptococcus mutans and Poryphormonas gingivalis

https://www.mdpi.com/2076-3417/12/7/3491

Aloe vera: It's effect on gingivitis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800403/

Vitamin D reduces the inflammatory response by Porphyromonas gingivalis infection

https://www.sciencedirect.com/science/article/abs/pii/S1567576917301182

The Role of Vitamin C and Vitamin D in the Pathogenesis and Therapy of Periodontitis—Narrative Review

https://www.mdpi.com/1422-0067/24/7/6774

Effects of Oral Commensal Streptococci on Porphyromonas gingivalis Invasion into Oral Epithelial Cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345648/

Heat-killed Lactobacillus reuteri and cell-free culture supernatant have similar effects to viable probiotics during interaction with Porphyromonas gingivalis

https://onlinelibrary.wiley.com/doi/abs/10.1111/jre.12704

Streptococcus gordonii programs epithelial cells to resist ZEB2 induction by Porphyromonas gingivalis

https://www.pnas.org/doi/10.1073/pnas.1900101116

Calcium ions and vitamin B₁₂ are growth factors for Porphyromonas gingivalis

https://www.sciencedirect.com/science/article/abs/pii/S1349007922001256

Exopeptidases and gingipains in Porphyromonas gingivalis as prerequisites for its amino acid metabolism

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382784/

High glucose appeared to enhance the inflammatory response induced by the periodontal pathogen.

https://aap.onlinelibrary.wiley.com/doi/abs/10.1902/jop.2013.130009

The periodontal pathogen Porphyromonas gingivalis harnesses the chemistry of the μ-oxo bishaem of iron protoporphyrin IX to protect against hydrogen peroxide

https://academic.oup.com/femsle/article/183/1/159/551813

Is Toxoplasma gondii a potential risk factor for Alzheimer's disease? A systematic review and meta-analysis

https://www.sciencedirect.com/science/article/abs/pii/S0882401019308769

VACCINES

rgpA DNA vaccine induces protective immunity against infection by Porphyromonas gingivalis in a murine model

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC98235

RgpA-Kgp peptide-based immunogens provide protection against Porphyromonas gingivalis challenge in a murine lesion model

https://pubmed.ncbi.nlm.nih.gov/10858222/

IMPLICATIONS

Minimismal Monsters in Our Blood and Brains: The Patient's Psychiatric Germ Theory of 1833

https://pubmed.ncbi.nlm.nih.gov/31885027/

Focal Infection and Periodontitis: A Narrative Report and New Possible Approaches