He's so crispy

Melania Trump presides at UN Security Council meeting as U.S. attacks Iran

Trump Rambles About Golden Drapes in White House as Americans Die Overseas

State of the Insanity

 Flaccid men with impulse control problems.   All over the world.

The Trump-Netanyahu call that changed the Middle East

He has active herpes

That is shingles on his neck.  Herpes Zoster.   That's a strong contributor to Alzheimer's.  

I had shingles on the top of my head  It's really painful    I couldn't function for 3 weeks.  

It seems probable that whatever they are infusing into his hand has lowered his immune response.    Microbial Whak-a-Mole.   My old friend....

Diagonal Earlobe Crease, a Marker of Coronary Artery Disease

In the meantime

Excerpts from:

Sexual dimorphism in bacterial infections

Periodontal infections show sexual dimorphism, for instance, men are more susceptible than women to develop periodontitis, which as other infections are mainly attributed to the elevated production of pro-inflammatory cytokines in response to differential gene regulation through the action of sex steroid hormones.   Interestingly, chronic periodontal inflammation is considered a cause of endothelial dysfunction by inducing reactive oxygen species production, that in turn contributes to the development of cardiovascular diseases, which are more frequent in men than in women.

Testosterone generally functions as a suppressor at early stages of infection, but as an activator during the late response to infection, as it occurs during sepsis; whereas, estradiol acts as an activator, and progesterone functions as an immunosuppressive agent, mainly during pregnancy.

In general, males are more susceptible to gastrointestinal and respiratory bacterial diseases and sepsis, while females are more susceptible to genitourinary tract bacterial infections. However, these incidences depend on the population evaluated, animal model and the bacterial species. Female protection against bacterial infections and the associated complications is assumed to be due to the pro-inflammatory effect of estradiol, while male susceptibility to those infections is associated with the testosterone-mediated immune suppression.

Certain gastrointestinal infections are more recurrent and severe in men than in women. This sexual dimorphism can be explained in part because of behavioral differences during hygiene and eating practices, such as handwashing before food handling and eating, storage, refrigeration, and defrosting practices, and tendency of men to eat undercooked or raw food, as well as to ingest roadside food .

During gastrointestinal injury, males produce predominantly pro-inflammatory cytokines, as compared with females whose intestine produce anti-inflammatory factors. in turn, the inflammatory response in males leads to perforation and cell necrosis at the site of infection.

Infections caused by Helicobacter pylori affect predominantly males, and its outcomes, such as gastritis, peptic ulcer, and gastric cancer, are also more frequent in males

It has been suggested that male sex is a frequent risk factor and a predictor of worse outcome for most of the respiratory tract infections, with exception of some upper respiratory tract infections (sinusitis, tonsillitis, and otitis externa) that are more frequently found in females.

The incidence of community-acquired pneumonia is higher in men than in women, and this incidence increases by age, especially in infections with Streptococcus pneumoniae, Streptococcus pyogenes, Chlamydophila pneumonia, and Legionella pneumophila.

In fact, male gender is considered as one of the four risk factors associated with the development of sepsis in general surgical and post-traumatic patients, with a hospital mortality rate of 70% in male and 26% in female patients.

One of the most used models to simulate bacteremia is LPS injection into bloodstream, which is known as experimental endotoxemia. Although there are controversies about the mechanisms involved in the sexual dimorphism of LPS response, it is accepted that males are more affected than females in LPS-induced endotoxemia.

 A large number of genes related to immune functions are located on the X chromosome, X-linked mosaicism allows women to respond with a more expanded immune repertoire as compared with men.

Among other diseases that display a sex-based predominance are urinary tract infections (UTIs), which are present in females more often than in males. UTIs in women occur more frequently than in men due to anatomical and physiological differences; for example, the urethra is shorter than that of men, and the distance between the anus and urethral meatus is also shorter in women. Additionally, the perimeatal region has less humidity in men than in women and prostatic secretions show antibacterial activity; therefore, the probability of bacterial colonization and development of infection is lower in men.

(I believe this is why women get more upper respiratory infections.  Our heads and necks and mouths and sinuses are smaller)

Sexually transmitted infections also have female predominance; as it is the case of infections of the genital tract caused by Chlamydia and and Neisseria gonorrhoeae. 

Aging and menopause also influence the immune system function, increasing the predisposition to infections. During menopause, there is a significant reduction in sex steroid hormone synthesis with a concomitant decrease in immune cell levels and their functional capacity.

Uh-huh

 Ndiaga Diagne was identified as the gunman who killed two people and injured 14 others during a mass shooting at a bar in Austin, Texas.

Yeah, he's been exhibiting aggressive behavior for a long time.  

He apparently started taking diet drugs.  Considering the psychosis,  I'd guess amphetemines.

It's a mystery

‘Boy kibble’: why are young men turning to dog food for meal inspiration?

Digestive and motivational disorders caused by terrible medical advice?

We will not forget

Trump and Israel are still all over the Epstein Files.   I think we should change the slogan to "Wag the Dick".

Article Roundup

Common pneumonia bacterium may fuel Alzheimer’s disease

Chlamydia pneumoniae can invade the retina and brain, where it sparks inflammation, nerve cell death, and the buildup of amyloid-beta—the hallmark protein linked to Alzheimer’s

 

The periodontal anaerobe Porphyromonas gingivalis induced platelet activation and increased aggregation in whole blood by rat model

Effect of Aspirin on aggregation of human platelets by Porphyromonas gingivalis

Potential of Curcumin in the Management of Skin Diseases

Surprising giant DNA discovery may be linked to gum disease and cancer

Large study finds no link between mRNA COVID vaccine in pregnancy and autism

Intermittent fasting fails to beat standard dieting for weight loss

yeah, in my day this was called bingeing and purging.

Middle age is becoming a breaking point in the U.S.

Compared with earlier generations, they report more loneliness and depression, along with weaker physical strength and declining memory.

Severe pregnancy sickness raises risk of mental health conditions by over 50%

red flag red flag red flag!

Fungus identified as key cause in Crohn's disease

In people with Crohn's, the researchers found two bacteria, E. coli and Serratia marcescens, move "in lock step" with the fungus Candida tropicalis, working to produce a biofilm that prompts inflammation typical of Crohn's disease.

Ambroxol may slow Parkinson’s dementia

Properties of ambroxol hydrochloride as an antibiofilm compound

Snug with your bugs? How microbes control your sleep

Much speculation and no mention of orexin

Metformin’s secret brain pathway revealed after 60 years

Amphetamines: a current epidemic

Chimps and the Ancestry of Alcohol: What a New Study Reveals About Our Shared Evolutionary Past

New Study Challenges Stereotypes of Mesolithic Women

(My belief:   Mesolithic women are the prehistoric geniuses who figured out how to brew alcohol.)

Some moments in the Matrix

Here's my lastest rambling screed. 

Auntie Zombie adds some thoughts

It really has been a glaring omission that I didn't have anything about sleep or eating disorders.   Sorry about that.

I still have plans for a discussion on Sexual dimorphism in immune responses.   I wish someone would write that for me....

In the meantime:    

High-Testosterone Men Have the Weakest Immune Responses

Good Article

New review.   Some chemistry jargon, but the main points are worth reading.  Has a section on Astrocytes, oh my.

Porphyromonas gingivalis: a potential trigger of neurodegenerative disease

Cortisol Exposure leads to Astrocyte dysfunction in Major Depression

Yeah.   That's what this experiment showed.

Chronic cortisol differentially impacts stem cell-derived astrocytes from major depressive disorder patients

Using the 7-day exposure paradigm, we studied the specific impact of chronic cortisol exposure in MDD patient-derived astrocytes with whole transcriptome analyses. We discovered uniquely disrupted pathways in MDD astrocytes exposed to chronic cortisol. Genes involved in GPCR ligand binding, ion transport, and synaptic transmission were uniquely affected by chronic stress in MDD astrocytes, notably the serotonin receptor HTR1B, the neurotrophic factor GDNF, and glutamate receptors GRM1 and GRM8. We have generated a novel in vitro chronic stress-like paradigm and provide evidence for the unique regulation of astrocyte genes in MDD.

Association of Porphyromonas gingivalis with high levels of stress-induced hormone cortisol in chronic periodontitis patients

Another 20-something shooter

 Austin Tucker Martin.   

His family has obvious dental and metabolic problems.  Let's guess infected 3rd molar for him.  I would check their APOE status too.  I used to look just like mom.   I see that lady everywhere.  There were three of us in my library school classes. And we all studied medical indexing not literature. I wondered why for about 15 years.

Everything Old is New Again

 Rerun.

On the topic of Cults

Since everyone has infections, everyone is susceptible to the symptoms.
Symptoms like depression and anxiety.
Religion and Cults and Psychs use this to manipulate you.   They get you in the door using that fact.   They literally seek people out who are in crisis to exploit these symptoms.
Then they start wasting your time.   Taking your money.   And making your symptoms worse.
They control your food and sleep and information.  They exhaust you.
They get you to confess your mistakes.    They learn the triggers of your habenula so they can make you feel bad at will.  Coerce you to comply.
When you do, then they give you positive social reinforcement to make you think your problem has been solved.
It hasn’t.   You’re still sick and your astrocytes are fossilizing in your brain.  All of your colleagues are infected too.  Your ability to think is diminishing.    
The longer you stay, the less ability you have to leave.

See the pathology

Cha Ching Ching Ching!

 Brain inflammation may be driving compulsive behavior

For years, compulsive behaviors have been viewed as bad habits stuck on autopilot. But new research in rats found the opposite: inflammation in a key decision-making brain region actually made behavior more deliberate, not more automatic. The change was linked to astrocytes, brain support cells that multiplied and disrupted nearby circuits. The discovery hints that some compulsive behaviors may arise from excessive, misdirected control rather than a loss of it.

Pam Bondi is a Zombie

 Hey Maga.   

In your haste to make a Christian Nation, you managed to let an Insane Cult Member take over the Justice Department.  Pam Bondi is not a Christian.   She is a Scientologist.   She is a fully brainwashed robot. 

There's a reason she is Attorney General for the Epstein class.  Scientologists believe that children have the same intellect, experience and decision making capacities as adults.   She has no problem ignoring the victims of human trafficking.   Her entire "religion" is based on exploiting child labor.  

That's how she got to be Attorney General of Florida.   Where she could ignore Jeffrey Epstein.   The billion dollar cult put her there to ignore their crimes.   And Trump has taken advantage of it.  

Trump's not a Christian either, you fuckin idiots.

Mood

Trump reads "The Snake" poem

Ladies and Gentlemen: The Secretary of Health and Human Services

Measles cases in US top 900 as CDC confirms infections in 24 states

See the Vortex

Chronic Illness is the goal of this administration. 

Herpes viruses contribute to Alzheimer's.  

The undisputed champion

Trump, 79, Sparks Health Concerns With Bizarre Slurring

Everyone thinks this is cognitive.  It is not.  It is dental infection.  (so was Biden's)  The cognitive problems are a whole different mechanism.

I told you his left side was bad.   Look at that swelling.   He's clearly got calcification in both of the main salivary ducts.  When the one under his tongue is pinched it derails his "S" pronunciation.   It's possible he had this one probed and dilated, or maybe he's got a bad tooth.

This event was fascinating because then the upper duct flinched and set off his phrenic nerve.   That weird phrase in the middle is Tourettes,  his mouth adjusting the salivary ducts and motor nerves with vocalization.  It sounds like something he WASN'T supposed to say, a diabolical hallmark of tics.

He clearly is used to this, he recovered without stopping.

Yeah, Me too.

Pop Quiz

Count the red flags.

Meet The Internet’s Most Disturbing New Influencer

Holy Frankenfuck

I am so tired of hearing about perverts.  Hearing the lies of perverts.  Paying for the crimes of perverts.  And living with my personal memories of perverts.

One more time:

On the topic of Toxic Masculinity

Now that I have pretty much satisfied most of my personal medical obsessions- I am going to turn my gaze on the one I think causes the most problems in the world:  Men’s obsession with their dicks.  

It’s pathological.  It has destroyed civilized society.

Here’s my hypothesis:   Your penises are never happy because you don’t know how they work.  They are mistreated and abused.   They become impaired.

First of all, most of them have been chronically infected by germs that live in saliva.   Do the math.

P. gingivalis impairs the sensory nerves in the skin.   That’s a big problem.  Sexual success is dependent on the ability to perceive pressure and vibrations. 

It also causes inflammation in the tissues.   Which is irritating.    Abrasions then allow the germs into blood vessels, and they get less elastic.

It also gets in the ducts and impairs the draining function.

I wouldn't be surprised if it traveled to your spine and gave you all that back pain...

 

Secondly, you don’t know how to operate them properly.   You’re terrible drivers.

Orgasm does not just occur in the genitals.   It also drains the glands in the face and throat.  You never ever include that in your workout.   There are vibration sensors in your nasal sinuses too.  You must move your head and neck, you need to stretch your face and tongue.  If you synchronize this with your hips, you will be able to drain your cranium and relax completely.   Yes it looks stupid, but it’s important.

It’s not a wonder you people are never happy.  

Stop blaming women.  You’re the ones suffering from Hysterical Suffocation.  Y'all should have figured that out a long time ago.  Try some curcumin soap and lotion instead.  Reduce your inflammation and infectious burden.  Fix your nasty teeth, they impair your facial nerves.  Clean your mouth and nose before sex too.

And please, stop doing weird anti-masturbation rituals.  It’s quite healthy and satisfying if you do it right.

What a dick

He took over the Kennedy Center to host the premier of Melania's ridiculous movie.  

Her silence really is golden.

(my peeps know he fell asleep after three minutes in the dark)

See the vortex

 Oh my.   Fucking Brilliant.  

Christopher Titus | Carrying Monsters (Full Comedy Special)

Notice:  NSFW..  ALL the trigger warnings.   

"These are not my teeth"  😬

Are we Great yet?

Trump cannot remember the word Alzheimer's

Big Boy Toys

It seems he invaded Venezuela for the Peace Prize. 

I wonder if he will pardon Maduro, now that he has it.

Now he's threatening NATO to distract them.   

Putin is up to something.