There it is

The Ultimate Delusion.

The Biggest Con Ever.

More fun for me

Astrocytic metabolic control of orexinergic activity in the lateral hypothalamus regulates sleep and wake architecture

In conclusion, our results provide evidence for the importance of the astrocytic lactate shuttle in regulating sustained wakefulness. By using cell-specific downregulation of MCTs, we demonstrate that astrocytes are a major contributor to lactate export into the extracellular environment where it is available for uptake by orexinergic neurons, modulating their activity and ultimately regulating wakefulness.

My Favorite Researcher

How this whole thing started:

Back in the 2010’s, I used to hang out on Narcolepsy forums and post my ideas.   A student named Christina asked to write to me about dieting.  She had noticed that we fell asleep after eating. And the gluten effect too.   We were both amazed by how much better we felt when we didn’t eat at all.     

We tried gluten free-ketogenic diets.   It was the first experiment.  It was the first biohack.

We went to conferences and watched people fall asleep after eating.   It wasn’t just us.

She went to grad school and became a metabolic researcher.   She’s a professor now.  She studies orexin and intestines.  In tiny little zebrafish guts.

She has just published a paper validating that first hypothesis. 

Orexinergic responses to environmental stressors in the zebrafish gut

Basically:  Orexin levels increase during fasting.  Orexin levels decrease after eating   And it occurs in the intestinal wall as well as the brain.  

Cha Ching.   Bravo.   Way to go, Professor Graves!!

 

I’m glad I lived long enough to read that on the internet.

And see it indexed in PubMed.   That’s my freaky kind of fun.

Dear Boys

This is why we cannot let you drink a lot of alcohol and have a lot of weapons.  You WILL kill us all.   

The Forgotten Prehistoric War That Killed 95% Of All Men   video

State of the Insanity

I am beginning to believe he wants to be hospitalized.  

It's a viable exit strategy.

Plausible deniability is the preferred weapon of sociopaths.

Happy High Holy Day Maga

 Very high.  

Oh Really

Once Thought To Support Neurons, Astrocytes Turn Out To Be in Charge

These overlooked brain cells may control fear and PTSD

Taking a closer look at astrocytes and autism

Gum disease may quietly damage the brain
People with gum disease may have higher levels of brain white matter damage, a new study finds.  

White matter is ASTROCYTES.

This is my all time favorite scientific article:

The Other Half of the Brain  

I read this... in Print... the week it was published.   It rearranged my circuitry.

Priorities on Display

 

Oh the Irony

 Zombie Jones opines on Zombie Trump

Maga Mamas

Your Precious Grandchildren will never forgive you.

Reap what you have sown.

What the Actual Fuck

Keep up the good fight

 No Kings 3

Another Souvenir

 from here

Quickie Hypothesis

The Evolutionary Benefit of Insulin Resistance

It is much more difficult to starve us.   Almost everything we eat turns to fat and becomes long term energy storage. 

We are the ones who survive the famines, eating nothing but potatoes or rice or bread.

Meanwhile

Tucson, AZ recorded its earliest 100-degree day in history Today, reaching the mark at 2:05 p.m., which also broke the city's record for the hottest March day ever.

The previous record was April 11, last year.

Toxic Masculinity

Am I right that the people who love petroleium the most are just blowing it up and setting it on fire?   

I hate them.   So much.  

Not all men.   But always men.

Impulse control problems

There seems to be a lot of discussion about Tourette"s on the interwebs lately, because of the outburst at the BAFTA's.   

I'm not sure if he's for real.   It's not a word I've ever had the urge to say.   

However, I do know why we say Fuck a lot.

N sounds push behind the upper incisors, they are a common problem.  But the rest of the N-word is not helpful for me.  It interrupts the motion.  "No no no no no" works much better. 

Update:   He's for real.   But I'm not sure that tic torrent was.   It got a lot of media attention for his movie.

Yo Brittania:

These are his upper teeth.  His gums and sockets are destroyed.  The incisors and canines have been ground flat.  His lower lip never moves, so I'm assuming those teeth and sockets are worse.  I don't want to think about the molars.

Doctors never noticed he has mouth problems?  WTF.

Practical Zombipathy

Further Adventures with Microbial Whak-a-Mole.

 

Today I am going to discuss foot and nail fungus.

The fungus can create a biofilm with PG and they both become more resistant, so you have to treat them both, or you will continue reinfecting yourself.

With that knowledge I have concocted a foot soak that seems effective.

I actually feel like I’m walking on someone elses’ legs…

 

Here’s my recipe for a small batch.

8 oz /200 ml  liquid castille soap.    I don’t know if there is any difference between brands.   It probably doesn’t matter, it is just to dissolve the oils.

10 drops Curcumin extract.  

10 drops Tea tree oil

Mix well.  

Use 1 tsp/ 15ml of the soap  per 2 cups/0.5 l  of water in your basin.  It wil not be foamy.   You only have to cover the bottom of your feet and make sure it gets on your toenails and in between your toes.   I have a toothbrush I use to do my toes. 

Edit:   5 minutes seems to be enough and causes less itching.   

Rinse your feet with clean water.  Dry them thoroughly.   Put on clean socks.   Cotton or wool are best.

Don’t forget to soak all your metal nail tools too.   Disinfect your tub and shower curtain with bleach. 

Get a new pumice stone in this shape.  You will be able to grind off your calluses.

I've been doing it every other day. 

There is something about the soap and water carrier that permeates the skin more than lotion.

Curcumin inhibits PG and seems to open water channels in the skin cells.  

Tea tree oil inhibits fungus and viruses. 

For further healing and itch relief, use lidocaine cream on problematic spots.  It’s very antimicrobial and also numbs the skin.  It’s in the burn relief or arthritis section.    I like the ones that are “non-greasy”.

I'm old

Why have I never heard of this before?   

Generation Jones is the generation or social cohort sandwiched between the Baby Boomers and Generation X. 

The Watergate scandal in 1972 was a formative political event for Generation Jones, contributing significantly to their characteristic distrust of government and general cynicism.

Heh.  yeah, general cynicism.   LOL.   

video

Update

I feel much better.   It popped out with no problems.  I won't miss it.  

Different dentist.   Same pitch for implants.   No thanks.

Off to the dentist

To have another tooth removed.   The third crown has failed.  Another tooth my dentists destroyed with inappropriate treatment.  

The total is now seven.  That doesn't include the four wisdom teeth that actually needed to go (much sooner than they did).

Sigh

 For some reason I have been reminded of this old joke a lot lately

Correlation Games

Steven Cheung   Trump political advisor, White House communications director.

Steve Bannon-   former White House Chief Strategist, advisor to Jeffrey Epstein.

Stephen Miller   White House deputy chief of staff for policy and homeland security advisor.

Tick Tick Tick Tick Tick

 60 Minutes-  Havana Syndrome investigation is "a massive CIA cover-up"

For years, the U.S. government has doubted the stories of those suffering from AHI, commonly called Havana Syndrome. Now, victims hope that reports of a newly discovered weapon will finally vindicate them.

You dispicable men have been dreaming of this kind of silent, invisible power forever.    Fuck all y'all.

Boys will be Boys

Russia, China, and Iran have joined forces.

Bibi and Trump want to Nuke Iran.   More than anything.   Neither one of those demented zombies will ever stop thinking about it now.

Trump thinks he can get their Uranium.   What he will get: our most elite commandos slaughtered.

Hegseth and Miller will shrug.

And Putin will dance.

O Superman.