Expected Behavior

How periodontitis-linked bacteria accelerate Osteoporosis-like bone loss through the gut

Porphyromonas gingivalis extracellular vesicles exacerbate Osteoporosis by disrupting osteoblast mitochondria

Brain Tumors too.

 Identification of gingipains in glioblastoma tumors and evidence that P. gingivalis infection drives IL-6 and PD-L1 expression in glioma cells

Porphyromonas gingivalis—a key oral bacterium linked to chronic periodontitis and Alzheimer’s disease pathology—produces virulence factors found within glioblastoma tumor tissue.

It significantly boosts the invasiveness and migration of glioma cells in a viability-dependent manner.

I knew it.

I did this search a couple years ago.   There was nothing.  I was pretty sure though...

Bacteria inside Melanoma tumors may offer clues about cancer outcomes

Current research shows an emerging, preliminary link between Porphyromonas gingivalis (and the Porphyromonas genus) and worse melanoma outcomes, though direct causation is not yet established.

And that reminded me of PG's constant companion...

A fungus living in our body can make melanoma more aggressive

The fungus activates several signaling pathways in the melanoma cells, and as a result, creates an environment that ...produces suitable conditions enabling the malignant cells to acquire more oxygen and energy and be spread more easily to the blood and other organs.

See the vortex. 

File under Go Figure

Russia has an HIV epidemic because they are re-using single-use medical supplies.

Wearable sleep trackers are using your brainwaves to train AI models without explicit user consent — tens of millions of hours of EEG data harvested

For decades, we were told to avoid full-fat dairy. New research says otherwise

Energy Drinks Linked to 11 Times More Reports of Cardiac Arrest

Listen to this old lady:  Gat a drip coffeemaker.   Drink coffee.   It's heart healthy.  

Resveratrol inhibits periodontal pathogens in vitro   

That explains the red wine paradox.  But it doesn't counteract the effect of the alcohol...

An anti-aging drug may help protect the brain before Alzheimer's symptoms begin

 Researchers found that just four weeks of low-dose Rapamycin improved brain blood flow in healthy middle-aged adults carrying the high-risk APOE4 gene variant, with women showing the strongest benefits.

Rapamycin lowers the amount of immune response. This is why it preferentially improves female symptoms.

one search later:

Porphyromonas gingivalis Provokes Exosome Secretion and Paracrine Immune Senescence in Bystander Dendritic Cells

Preclinical and animal studies indicate that Rapamycin can reverse pathogen-induced cellular senescence and restore immune/dendritic cell function affected by P. gingivalis. In aging mice, Rapamycin treatment has also been observed to reduce alveolar bone loss and shift the oral microbiome back toward a healthier, younger composition.

I have a bookmarked search for PG on PubMed.   I just type in the other search term I am interested in and press enter.... it works almost every time.  

Everyone really really, really wants to sell you a drug, not cure your infection.

Idiocracy

He's still crazy   And he's still got the nuclear codes.

He said this was a joke.   It was not.  

 The Dana White Debacle   by Jeff Tiedrich.  

Zombie Update

Horrific

Correlation Games

Mamdami is older.

Miller has worse problems than aging.   (previously)

But of course

The influence of periodontal disease and periodontal treatment on colorectal cancer

Periodontal pathogenic bacteria Fusobacterium nucleatum (FN) and Porphyromonas gingivalis (PG), are most linked to colorectal cancer (CRC), from the mucosa of the cancer-affected intestine.

Oral Bacteria and Intestinal Dysbiosis in Colorectal Cancer

Porphyromonas gingivalis Promotes Colorectal Carcinoma by Activating the Hematopoietic NLRP3 Inflammasome

A very good reason not to drink alcohol.

Ladies...

I don't know how I missed this....

Rete Ovarii: The Unsung but CRUCIAL Player in Women's Reproductive Health

It has lots of nerves and blood vessels, seems like a nice home for microbes.

Extinction level Idiocy

Robert F. Kennedy Jr. vows to 'unleash the Kraken' with powerful new MAHA tool by his side

Ummm, the Kraken is a predatory killer.   Not healthy for children or other living things...

This is a euphemism for genocide via medical discrimination and abuse.

Great Science News!

Stanford scientists discover a way to reverse coral bleaching at record speed

Good video

Piggy and the Brain

Buckle up everyone.  Their habenulas are on fire.  Predatory men who can't handle rejection are capable of anything.  (bonus jump scare)

A few things

 Dental implants can hijack your immune system, scientists discover

Mechanisms of Porphyromonas gingivalis to translocate over the oral mucosa and other tissue barriers     A fairly readable scientific article with diagrams.

 Tiny Genetic Tweak From An Ancient Virus Might've Prevented Chimpanzees From Developing Brains Like Ours

This mysterious mushroom makes people see hundreds of tiny humans

Common drugs may help dangerous viruses spread through the body

Porphyromonas gingivalis induced periodontitis exacerbates progression of non‐alcoholic steatohepatitis in rats

Answer to the quiz.  

I bought a souvenir

 I have wanted this for years. Now I must have it.

Thanks America

 Blue is my favorite color.

Palate Cleanser

 A Good Hypothesis

Been there, done that

Watch Trump fall asleep STANDING UP

Nauseously Optimistic

Vote like your life depends on it.   Because it does.

Photo finish

 Narcissus is ready for his close-up

"A massive piece of pool"

Just do it

 I voted early today.

Sick in the Head

 From the man who destroyed healthcare in America:

See the Pathology

A complete lack of empathy.

    

 

https://x.com/Acyn/status/2114153893248803088  

Pop Quiz

WTF is this?

Follow up

As I was saying...            

Women with Polycystic Ovary Syndrome (PCOS) face an elevated risk of postpartum depression, with studies showing a roughly 45% to 50% higher likelihood compared to women without PCOS.

Polycystic ovary syndrome and postpartum depression symptoms: a population-based cohort study

A fine specimen

 

Another one