Another Souvenir

 from here

Quickie Hypothesis

The Evolutionary Benefit of Insulin Resistance

It is much more difficult to starve us.   Almost everything we eat turns to fat and becomes long term energy storage. 

We are the ones who survive the famines, eating nothing but potatoes or rice or bread.

Meanwhile

Tucson, AZ recorded its earliest 100-degree day in history Today, reaching the mark at 2:05 p.m., which also broke the city's record for the hottest March day ever.

The previous record was April 11, last year.

Toxic Masculinity

Am I right that the people who love petroleium the most are just blowing it up and setting it on fire?   

I hate them.   So much.  

Not all men.   But always men.

Impulse control problems

There seems to be a lot of discussion about Tourette"s on the interwebs lately, because of the outburst at the BAFTA's.   

I'm not sure if he's for real.   It's not a word I've ever had the urge to say.   

However, I do know why we say Fuck a lot.

N sounds push behind the upper incisors, they are a common problem.  But the rest of the N-word is not helpful for me.  It interrupts the motion.  "No no no no no" works much better. 

Update:   He's for real.   But I'm not sure that tic torrent was.   It got a lot of media attention for his movie.

Yo Brittania:

These are his upper teeth.  His gums and sockets are destroyed.  His lower lip never moves, so I'm assuming those teeth are worse.  I don't want to think about the molars.

Doctors never noticed he has mouth problems?  WTF.

Practical Zombipathy

Further Adventures with Microbial Whak-a-Mole.

 

Today I am going to discuss foot and nail fungus.

The fungus can create a biofilm with PG and they both become more resistant, so you have to treat them both, or you will continue reinfecting yourself.

With that knowledge I have concocted a foot soak that seems effective.

I actually feel like I’m walking on someone elses’ legs…

 

Here’s my recipe for a small batch.

8 oz /200 ml  liquid castille soap.    I don’t know if there is any difference between brands.   It probably doesn’t matter, it’s just a carrier.

10 drops Curcumin extract.  

10 drops Tea tree oil

Mix well.  

Use 1 tsp/ 15ml of the soap  per 2 cups/0.5 l  of water in your basin.  It wil not be foamy.   You only have to cover the bottom of your feet and make sure it gets on your toenails and in between your toes.   I have a toothbrush I use to do my toes. 

Edit:   5 minutes seems to be enough and causes less itching.   

Rinse your feet with clean water.  Dry them thoroughly.   Put on clean socks.   Cotton or wool are best.

Don’t forget to soak all your metal nail tools too.   Disinfect your tub and shower curtain with bleach. 

I've been doing it every other day. 

There is something about the soap and water carrier that permeates the skin more than lotion.

Curcumin inhibits PG and seems to open water channels in the skin cells.  

Tea tree oil inhibits fungus and viruses. 

For further healing and itch relief, use lidocaine cream on problematic spots.  It’s very antimicrobial and also numbs the skin.  It’s in the burn relief or arthritis section.    I like the ones that are “non-greasy”.

I'm old

Why have I never heard of this before?   

Generation Jones is the generation or social cohort sandwiched between the Baby Boomers and Generation X. 

The Watergate scandal in 1972 was a formative political event for Generation Jones, contributing significantly to their characteristic distrust of government and general cynicism.

Heh.  yeah, general cynicism.   LOL.   

video

Update

I feel much better.   It popped out with no problems.  I won't miss it.  

Different dentist.   Same pitch for implants.   No thanks.

Off to the dentist

To have another tooth removed.   The third crown has failed.  Another tooth my dentists destroyed with inappropriate treatment.  

The total is now seven.  That doesn't include the four wisdom teeth that actually needed to go (much sooner than they did).

Sigh

 For some reason I have been reminded of this old joke a lot lately

Correlation Games

Steven Cheung   Trump political advisor, White House communications director.

Steve Bannon-   former White House Chief Strategist, advisor to Jeffrey Epstein.

Stephen Miller   White House deputy chief of staff for policy and homeland security advisor.

Tick Tick Tick Tick Tick

 60 Minutes-  Havana Syndrome investigation is "a massive CIA cover-up"

For years, the U.S. government has doubted the stories of those suffering from AHI, commonly called Havana Syndrome. Now, victims hope that reports of a newly discovered weapon will finally vindicate them.

You dispicable men have been dreaming of this kind of silent, invisible power forever.    Fuck all y'all.

Boys will be Boys

Russia, China, and Iran have joined forces.

Bibi and Trump want to Nuke Iran.   More than anything.   Neither one of those demented zombies will ever stop thinking about it now.

Trump thinks he can get their Uranium.   What he will get: our most elite commandos slaughtered.

Hegseth and Miller will shrug.

And Putin will dance.

O Superman.

State of the Insanity

At Largest ICE Detention Camp, Staff Bet on Detainee Suicides

Simply Barbaric.   Same as it ever was.

As I was saying

A quote from me:

P. gingivalis highly activates the Habenula in the brain.  The habenula causes panic attacks and major depressive disorder.  Avoidance behavior.  Fleeing from aversive stimuli.

That part of the brain tells you if it thinks your decisions are wrong.   An overactive habenula makes you think your decisions are always wrong.   Your behavior is wrong.  Everything you do is wrong. Everything you ever have done is wrong.   Everything you ever will do will be wrong.  Acute dysfunction creates the feeling of absolute futility and is the source of suicidality.

Yeah, been there, done that. My entire life.  It really makes being told you’ve made a mistake an excruciating experience.   It makes you hate and avoid authority.   You blame them for causing your pain.

It’s almost impossible to admit a mistake. It feels like the end of the world.  We’ll do anything to avoid it.

That explains a whole lot of things I see every day.

This too:

Worldwide Prevalence of Impacted Third Molars is 37%

I Love Leslie

OMG.   

Leslie Jones Fixes Men

NSFW.

Dear Stormy

Did you notice bite marks on the mushroom?   Inquiring minds...

25th Please

Kristi Noem is out.  

ICE can't wear masks.   

The department of Justice has released the 302 files about nasty Trump.

Somebody has decided it's time for him to go.

Let's see how long it takes.

Unemployment is insane.  Gas prices are skyrocketing.  The stock market is plummeting.

Today would be good.

Trump tells CNN Cuba is soon going to fall: ‘I’m going to put Marco over there’

Make it stop

He forgot where his father was born.  Twice.   His orexin levels are so low he can barely move his mouth muscles.   He can barely mumble.  He's talking in his sleep.

He's got Dementia and Tourettes, Active Herpes, dental problems and is clearly on drugs.   

His mouth is now moving indepedently of his brain.   Which Cannot Recall Proper Names  or Places or Numbers.  A DEFINITE SIGN OF ASTROCYTE ACTIVATION.

His mouth is a Robot Mad Lib.   He fills in the gaps with similar words. Like an AI text generator.  He's babbling nonsense.

Somebody needs to hospitalize him.    Amyloid test him immediately.

He's the single greatest danger on the planet.

Our military is strung out all over the world.

We are losing people and infrastructure every day.

NATO is fractured.

And Putin is going to die happy.

Dear young people-  save this clip.   You will need it to teach your children history in the future.   They won't believe you.

He's so crispy

Melania Trump presides at UN Security Council meeting as U.S. attacks Iran

Trump Rambles About Golden Drapes in White House as Americans Die Overseas

State of the Insanity

 Flaccid men with impulse control problems.   All over the world.

The Trump-Netanyahu call that changed the Middle East

He has active herpes

That is shingles on his neck.  Herpes Zoster.   That's a strong contributor to Alzheimer's.  

I had shingles on the top of my head  It's really painful. It clogs up your brain.  I couldn't function for 3 weeks.  

It seems probable that whatever they are infusing into his hand has lowered his immune response.    Microbial Whak-a-Mole.   My old friend....

Diagonal Earlobe Crease, a Marker of Coronary Artery Disease

In the meantime

Excerpts from:

Sexual dimorphism in bacterial infections

Periodontal infections show sexual dimorphism, for instance, men are more susceptible than women to develop periodontitis, which as other infections are mainly attributed to the elevated production of pro-inflammatory cytokines in response to differential gene regulation through the action of sex steroid hormones.   Interestingly, chronic periodontal inflammation is considered a cause of endothelial dysfunction by inducing reactive oxygen species production, that in turn contributes to the development of cardiovascular diseases, which are more frequent in men than in women.

Testosterone generally functions as a suppressor at early stages of infection, but as an activator during the late response to infection, as it occurs during sepsis; whereas, estradiol acts as an activator, and progesterone functions as an immunosuppressive agent, mainly during pregnancy.

In general, males are more susceptible to gastrointestinal and respiratory bacterial diseases and sepsis, while females are more susceptible to genitourinary tract bacterial infections. However, these incidences depend on the population evaluated, animal model and the bacterial species. Female protection against bacterial infections and the associated complications is assumed to be due to the pro-inflammatory effect of estradiol, while male susceptibility to those infections is associated with the testosterone-mediated immune suppression.

Certain gastrointestinal infections are more recurrent and severe in men than in women. This sexual dimorphism can be explained in part because of behavioral differences during hygiene and eating practices, such as handwashing before food handling and eating, storage, refrigeration, and defrosting practices, and tendency of men to eat undercooked or raw food, as well as to ingest roadside food .

During gastrointestinal injury, males produce predominantly pro-inflammatory cytokines, as compared with females whose intestine produce anti-inflammatory factors. in turn, the inflammatory response in males leads to perforation and cell necrosis at the site of infection.

Infections caused by Helicobacter pylori affect predominantly males, and its outcomes, such as gastritis, peptic ulcer, and gastric cancer, are also more frequent in males

It has been suggested that male sex is a frequent risk factor and a predictor of worse outcome for most of the respiratory tract infections, with exception of some upper respiratory tract infections (sinusitis, tonsillitis, and otitis externa) that are more frequently found in females.

The incidence of community-acquired pneumonia is higher in men than in women, and this incidence increases by age, especially in infections with Streptococcus pneumoniae, Streptococcus pyogenes, Chlamydophila pneumonia, and Legionella pneumophila.

In fact, male gender is considered as one of the four risk factors associated with the development of sepsis in general surgical and post-traumatic patients, with a hospital mortality rate of 70% in male and 26% in female patients.

One of the most used models to simulate bacteremia is LPS injection into bloodstream, which is known as experimental endotoxemia. Although there are controversies about the mechanisms involved in the sexual dimorphism of LPS response, it is accepted that males are more affected than females in LPS-induced endotoxemia.

 A large number of genes related to immune functions are located on the X chromosome, X-linked mosaicism allows women to respond with a more expanded immune repertoire as compared with men.

Among other diseases that display a sex-based predominance are urinary tract infections (UTIs), which are present in females more often than in males. UTIs in women occur more frequently than in men due to anatomical and physiological differences; for example, the urethra is shorter than that of men, and the distance between the anus and urethral meatus is also shorter in women. Additionally, the perimeatal region has less humidity in men than in women and prostatic secretions show antibacterial activity; therefore, the probability of bacterial colonization and development of infection is lower in men.

(I believe this is why women get more upper respiratory infections.  Our heads and necks and mouths and sinuses are smaller)

Sexually transmitted infections also have female predominance; as it is the case of infections of the genital tract caused by Chlamydia and and Neisseria gonorrhoeae. 

Aging and menopause also influence the immune system function, increasing the predisposition to infections. During menopause, there is a significant reduction in sex steroid hormone synthesis with a concomitant decrease in immune cell levels and their functional capacity.

Uh-huh

 Ndiaga Diagne was identified as the gunman who killed two people and injured 14 others during a mass shooting at a bar in Austin, Texas.

Yeah, he's been exhibiting aggressive behavior for a long time.  

He apparently started taking diet drugs.  Considering the psychosis,  I'd guess amphetemines.

It's a mystery

‘Boy kibble’: why are young men turning to dog food for meal inspiration?

Digestive and motivational disorders caused by terrible medical advice?