Silver Alert

Last seen sleeping in public.  Perfectly.

Another week missing at the end of the month.

Thanks for the evidence

Scientists found the hidden switch fueling Alzheimer’s brain inflammation

Scientists at Scripps Research have uncovered a molecular “switch” that appears to fuel the damaging brain inflammation seen in Alzheimer’s disease. They found that a protein called STING becomes chemically altered in a way that keeps the brain’s immune system stuck in overdrive, harming the connections between nerve cells.

Porphyromonas gingivalis induces an inflammatory response via the cGAS-STING signaling pathway in a periodontitis mouse model

Our results demonstrate that the cGAS-STING signaling pathway may be one of the key mechanisms crucial for the P. gingivalis-induced inflammatory response that leads to chronic periodontitis.

Proud Boy

ICYMI:   Greg Bovino had a playdate with his "just friends".

80 years old

Has anyone ever wanted to go to his birthday parties?

 Cancel it', Trump says after artists drop out of US Freedom 250 festival

As I was saying

Scientists discover why Alzheimer’s risk hits women so much harder

No they didn't.   Most of this is caused by the difference in men's and women's immune response.   

Their  list of "risk factors" are merely other (very profitable) manifestations of the infections that cause Alzheimer's. 

Men have suppressed immune systems due to anabolic steroids like testosterone.  

Women have increased immune responses triggered by estrogen.  

Since Alzheimer's is caused by a surplus of immune response molecules clogging up the brain...women will have more pathology.  The same imbalance applies to narcolepsy patients.

(I suppressed my ovaries with progesterone birth control from the time I was 16 until I was 50.   I participated in the clinical trials for all the forms:  pills, shots, and implants.  Looking back, it's surely one of the reasons I'm still alive.   Why I wasn't institutionalized.  Why I didn't just wither and die when I was 42 and the dementia set in.)

His Holy Grail

Here's the plan

Oh my.    Putin and Xi know this.   They're going to strike during a Cabinet Meeting.

Excellent Documentation of the Obvious

Man Didn’t Know How Weird Men Were Until He Changed His Profile To A Woman’s Picture On TikTok

On a tangent

I like this topic. 

The Evolution of Throwing

Origins of human throwing unlocked

I only ever throw things when I am really really pissed off.  I have never wanted to throw or catch a ball or anything else for fun.

My nephews started obsessively throwing rocks overhand when they were 2.

It's something I think about sometimes.  Ballistics. Strategy.   Long distance domination.  

And why men think about it all the time....

Yeah

 March 2021

Uh huh

 Sept 11, 2025.     Just sayin.

How about that

Mexico launches Universal Health Service registration, starting with elderly

I find it quite noteworthy that a google search does not find any major news outlets reporting this story.   

There is no bottom

Stop calling it a Ballroom just because he does.   Stop the construction immediately.

It's a Big Baby Bunker.   He has no plan to give up the keys to the White House.  That's why it's his priority.   He hasn't got much time to get it done.

It's got a restaurant and a hospital and a military command center so he can lay in bed, get his burgers and drugs, and shit himself while streaming the destruction of America life-size on massive TV screens.  

He's going to lock himself in and gather his human shields around the building.  If I were a gambler, I'd put money on that.  That's his kind of fun.

Cha Ching

I know his secret.

The goddess Nemesis is on her game.  She's going to take his mouth and face.  His very favorite things... (she already has the mushroom)

Here we go

The Functional Roles of Curcumin on Astrocytes in Neurodegenerative Diseases

have fun.   I'm still reading...

Mansplaining

Why women put up with more than they should  short video

I love her chirp after "plan ahead".   You don't say!  No kidding? <eyerolls>

It's also why we cooperate with eachother...

I would like to reframe that patronizing title:  Why men remain babies and believe their own bullshit. 

Article Roundup

Porphyromonas gingivalis promotes neuroinflammation and neuronal loss associated with dysfunction of the brain barrier

Curcumin attenuates cell migration in human ovarian cancer cells

Severe COVID or flu may raise lung cancer risk years later

Sepsis is linked to nearly one in five pediatric hospital deaths in the US

Scientists just discovered what coffee is really doing to your gut and brain

New study debunks the biggest fear about yo-yo dieting

A hidden map in your nose could explain how smell works

People who underwent root canal treatment experienced better blood sugar control 

Alzheimer’s drugs may not work and could raise brain risks
A major review finds Alzheimer’s drugs that remove amyloid may do little good- and could carry hidden risks.

Scientists reversed memory loss by recharging the brain’s tiny engines
more mitochondrial science soon...

What I Learned About Billionaires at Jeff Bezos’s Private Retreat
For the richest men on Earth, everything is free and nothing matters.

Sea shanties actually help people work together better

Pop Quiz

Eating eggs could cut Alzheimer’s risk by 27%

Researchers found that people 65 and older who eat eggs regularly have a significantly lower risk of developing Alzheimer’s disease, with daily or near-daily consumption linked to up to a 27% reduction. Even modest egg intake showed benefits, suggesting that small dietary changes could make a meaningful difference over time.

Find the critical flaw in their logic. (that pesky third variable)

Don't forget that this is exactly the opposite of what we were told for decades....

Inmates running the asylum

Of the psychopaths

For the psychopaths

By the psychopaths.

Oral Cancer for 1000, Alex

President Donald Trump will receive a dental examination later this month at Walter Reed National Military Medical Center, the third time he has visited the dentist this year.

TWENTY YEARS AGO!!!!!!!!!!

Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients

Cause and Effect

Neanderthals used stone drills to treat cavities 59,000 years ago, tooth suggests

I have to think that drugs were involved.   They clearly weren't stupid or unobservant.

Waiting for an Apology

Drinking Coffee Could Lower Dementia Risk by 35%, Scientists Say

That's better than their fancy drugs...

Go Fuckin Figure

Brain scans reveal a shocking difference between psychopaths and other people

Scientists have uncovered a striking brain difference linked to psychopathy: people with psychopathic traits were found to have a striatum — a brain region tied to reward, motivation, and decision-making — that was about 10% larger on average than those without such traits. Using MRI scans and psychological assessments on 120 participants, researchers connected this enlarged brain region to thrill-seeking, impulsive behavior, and a stronger drive for stimulation.

One search later:

Group A Streptococcus (strep throat), share molecular structures similar to proteins found in human brain cells. Following an infection, the body's immune system creates antibodies that mistakenly target the basal ganglia (which includes the striatum).

Antibodies from children with PANDAS bind specifically to striatal cholinergic interneurons and alter their activity

One more:

Characterization of Human Genes Modulated by Porphyromonas gingivalis Highlights the Ribosome, Hypothalamus, and Cholinergic Neurons

And of course:

Insular-striatal activation during COVID-19 predicts stress reactivity in high-trait anxiety

head desk.  head desk.    head desk.

So very weird

Even atheists know how this story ends.