Sunday, March 8, 2026

State of the Insanity

At Largest ICE Detention Camp, Staff Bet on Detainee Suicides


Simply Barbaric.   Same as it ever was.

As I was saying

A quote from me:

P. gingivalis highly activates the Habenula in the brain.  The habenula causes panic attacks and major depressive disorder.  Avoidance behavior.  Fleeing from aversive stimuli.

That part of the brain tells you if it thinks your decisions are wrong.   An overactive habenula makes you think your decisions are always wrong.   Your behavior is wrong.  Everything you do is wrong. Everything you ever have done is wrong.   Everything you ever will do will be wrong.  Acute dysfunction creates the feeling of absolute futility and is the source of suicidality.

Yeah, been there, done that. My entire life.  It really makes being told you’ve made a mistake an excruciating experience.   It makes you hate and avoid authority.   You blame them for causing your pain.

It’s almost impossible to admit a mistake. It feels like the end of the world.  We’ll do anything to avoid it.

That explains a whole lot of things I see every day.


This too:

Worldwide Prevalence of Impacted Third Molars is 37%

Saturday, March 7, 2026

I Love Leslie

OMG.   

Leslie Jones Fixes Men

NSFW.

Dear Stormy

Did you notice bite marks on the mushroom?   Inquiring minds...

Friday, March 6, 2026

25th Please

Kristi Noem is out.  

ICE can't wear masks.   

The department of Justice has released the 302 files about nasty Trump.

Somebody has decided it's time for him to go.

Let's see how long it takes.

Unemployment is insane.  Gas prices are skyrocketing.  The stock market is plummeting.

Today would be good.

Trump tells CNN Cuba is soon going to fall: ‘I’m going to put Marco over there’

Thursday, March 5, 2026

Make it stop

He forgot where his father was born.  Twice.   His orexin levels are so low he can barely move his mouth muscles.   He can barely mumble.  He's talking in his sleep.

He's got Dementia and Tourettes, Active Herpes, dental problems and is clearly on drugs.   

His mouth is now moving indepedently of his brain.   Which Cannot Recall Proper Names  or Places or Numbers.  A DEFINITE SIGN OF ASTROCYTE ACTIVATION.

His mouth is a Robot Mad Lib.   He fills in the gaps with similar words. Like an AI text generator.  He's babbling nonsense.

Somebody needs to hospitalize him.    Amyloid test him immediately.

He's the single greatest danger on the planet.


Our military is strung out all over the world.

We are losing people and infrastructure every day.

NATO is fractured.

And Putin is going to die happy.


Dear young people-  save this clip.   You will need it to teach your children history in the future.   They won't believe you.

Monday, March 2, 2026

He has active herpes

That is shingles on his neck.  Herpes Zoster.   That's a strong contributor to Alzheimer's.  

I had shingles on the top of my head  It's really painful. It clogs up your brain.  I couldn't function for 3 weeks.  

It seems probable that whatever they are infusing into his hand has lowered his immune response.    Microbial Whak-a-Mole.   My old friend....

Diagonal Earlobe Crease, a Marker of Coronary Artery Disease




In the meantime

Excerpts from:

Sexual dimorphism in bacterial infections

Periodontal infections show sexual dimorphism, for instance, men are more susceptible than women to develop periodontitis, which as other infections are mainly attributed to the elevated production of pro-inflammatory cytokines in response to differential gene regulation through the action of sex steroid hormones.   Interestingly, chronic periodontal inflammation is considered a cause of endothelial dysfunction by inducing reactive oxygen species production, that in turn contributes to the development of cardiovascular diseases, which are more frequent in men than in women.


Testosterone generally functions as a suppressor at early stages of infection, but as an activator during the late response to infection, as it occurs during sepsis; whereas, estradiol acts as an activator, and progesterone functions as an immunosuppressive agent, mainly during pregnancy.

In general, males are more susceptible to gastrointestinal and respiratory bacterial diseases and sepsis, while females are more susceptible to genitourinary tract bacterial infections. However, these incidences depend on the population evaluated, animal model and the bacterial species. Female protection against bacterial infections and the associated complications is assumed to be due to the pro-inflammatory effect of estradiol, while male susceptibility to those infections is associated with the testosterone-mediated immune suppression.

Certain gastrointestinal infections are more recurrent and severe in men than in women. This sexual dimorphism can be explained in part because of behavioral differences during hygiene and eating practices, such as handwashing before food handling and eating, storage, refrigeration, and defrosting practices, and tendency of men to eat undercooked or raw food, as well as to ingest roadside food .

During gastrointestinal injury, males produce predominantly pro-inflammatory cytokines, as compared with females whose intestine produce anti-inflammatory factors. in turn, the inflammatory response in males leads to perforation and cell necrosis at the site of infection.

Infections caused by Helicobacter pylori affect predominantly males, and its outcomes, such as gastritis, peptic ulcer, and gastric cancer, are also more frequent in males

It has been suggested that male sex is a frequent risk factor and a predictor of worse outcome for most of the respiratory tract infections, with exception of some upper respiratory tract infections (sinusitis, tonsillitis, and otitis externa) that are more frequently found in females.

The incidence of community-acquired pneumonia is higher in men than in women, and this incidence increases by age, especially in infections with Streptococcus pneumoniae, Streptococcus pyogenes, Chlamydophila pneumonia, and Legionella pneumophila.

In fact, male gender is considered as one of the four risk factors associated with the development of sepsis in general surgical and post-traumatic patients, with a hospital mortality rate of 70% in male and 26% in female patients.

One of the most used models to simulate bacteremia is LPS injection into bloodstream, which is known as experimental endotoxemia. Although there are controversies about the mechanisms involved in the sexual dimorphism of LPS response, it is accepted that males are more affected than females in LPS-induced endotoxemia.

 A large number of genes related to immune functions are located on the X chromosome, X-linked mosaicism allows women to respond with a more expanded immune repertoire as compared with men.

Among other diseases that display a sex-based predominance are urinary tract infections (UTIs), which are present in females more often than in males. UTIs in women occur more frequently than in men due to anatomical and physiological differences; for example, the urethra is shorter than that of men, and the distance between the anus and urethral meatus is also shorter in women. Additionally, the perimeatal region has less humidity in men than in women and prostatic secretions show antibacterial activity; therefore, the probability of bacterial colonization and development of infection is lower in men.
(I believe this is why women get more upper respiratory infections.  Our heads and necks and mouths and sinuses are smaller)

Sexually transmitted infections also have female predominance; as it is the case of infections of the genital tract caused by Chlamydia and and Neisseria gonorrhoeae. 

Aging and menopause also influence the immune system function, increasing the predisposition to infections. During menopause, there is a significant reduction in sex steroid hormone synthesis with a concomitant decrease in immune cell levels and their functional capacity.


Uh-huh

 Ndiaga Diagne was identified as the gunman who killed two people and injured 14 others during a mass shooting at a bar in Austin, Texas.

Yeah, he's been exhibiting aggressive behavior for a long time.  

He apparently started taking diet drugs.  Considering the psychosis,  I'd guess amphetemines.





Sunday, March 1, 2026

It's a mystery

‘Boy kibble’: why are young men turning to dog food for meal inspiration?

Digestive and motivational disorders caused by terrible medical advice?

Saturday, February 28, 2026

We will not forget

Trump and Israel are still all over the Epstein Files.   I think we should change the slogan to "Wag the Dick".




Article Roundup

Common pneumonia bacterium may fuel Alzheimer’s disease

Chlamydia pneumoniae can invade the retina and brain, where it sparks inflammation, nerve cell death, and the buildup of amyloid-beta—the hallmark protein linked to Alzheimer’s
 




yeah, in my day this was called bingeing and purging.

Compared with earlier generations, they report more loneliness and depression, along with weaker physical strength and declining memory.

red flag red flag red flag!

In people with Crohn's, the researchers found two bacteria, E. coli and Serratia marcescens, move "in lock step" with the fungus Candida tropicalis, working to produce a biofilm that prompts inflammation typical of Crohn's disease.






(My belief:   Mesolithic women are the prehistoric geniuses who figured out how to brew alcohol.)

Friday, February 27, 2026

Some moments in the Matrix

Here's my lastest rambling screed. 

Auntie Zombie adds some thoughts

It really has been a glaring omission that I didn't have anything about sleep or eating disorders.   Sorry about that.


I still have plans for a discussion on Sexual dimorphism in immune responses.   I wish someone would write that for me....

In the meantime:    

High-Testosterone Men Have the Weakest Immune Responses


Thursday, February 26, 2026

Good Article

New review.   Some chemistry jargon, but the main points are worth reading.  Has a section on Astrocytes, oh my.

Porphyromonas gingivalis: a potential trigger of neurodegenerative disease

Cortisol Exposure leads to Astrocyte dysfunction in Major Depression

Yeah.   That's what this experiment showed.

Chronic cortisol differentially impacts stem cell-derived astrocytes from major depressive disorder patients

Using the 7-day exposure paradigm, we studied the specific impact of chronic cortisol exposure in MDD patient-derived astrocytes with whole transcriptome analyses. We discovered uniquely disrupted pathways in MDD astrocytes exposed to chronic cortisol. Genes involved in GPCR ligand binding, ion transport, and synaptic transmission were uniquely affected by chronic stress in MDD astrocytes, notably the serotonin receptor HTR1B, the neurotrophic factor GDNF, and glutamate receptors GRM1 and GRM8. We have generated a novel in vitro chronic stress-like paradigm and provide evidence for the unique regulation of astrocyte genes in MDD.

Association of Porphyromonas gingivalis with high levels of stress-induced hormone cortisol in chronic periodontitis patients


Another 20-something shooter

 Austin Tucker Martin.   

His family has obvious dental and metabolic problems.  Let's guess infected 3rd molar for him.  I would check their APOE status too.  I used to look just like mom.   I see that lady everywhere.  There were three of us in my library school classes. And we all studied medical indexing not literature. I wondered why for about 15 years.



Wednesday, February 18, 2026

Everything Old is New Again

 Rerun.

On the topic of Cults

Since everyone has infections, everyone is susceptible to the symptoms.
Symptoms like depression and anxiety.
Religion and Cults and Psychs use this to manipulate you.   They get you in the door using that fact.   They literally seek people out who are in crisis to exploit these symptoms.
Then they start wasting your time.   Taking your money.   And making your symptoms worse.
They control your food and sleep and information.  They exhaust you.
They get you to confess your mistakes.    They learn the triggers of your habenula so they can make you feel bad at will.  Coerce you to comply.
When you do, then they give you positive social reinforcement to make you think your problem has been solved.
It hasn’t.   You’re still sick and your astrocytes are fossilizing in your brain.  All of your colleagues are infected too.  Your ability to think is diminishing.    
The longer you stay, the less ability you have to leave.

Tuesday, February 17, 2026

Cha Ching Ching Ching!

 Brain inflammation may be driving compulsive behavior

For years, compulsive behaviors have been viewed as bad habits stuck on autopilot. But new research in rats found the opposite: inflammation in a key decision-making brain region actually made behavior more deliberate, not more automatic. The change was linked to astrocytes, brain support cells that multiplied and disrupted nearby circuits. The discovery hints that some compulsive behaviors may arise from excessive, misdirected control rather than a loss of it.

Pam Bondi is a Zombie

 Hey Maga.   

In your haste to make a Christian Nation, you managed to let an Insane Cult Member take over the Justice Department.  Pam Bondi is not a Christian.   She is a Scientologist.   She is a fully brainwashed robot. 

There's a reason she is Attorney General for the Epstein class.  Scientologists believe that children have the same intellect, experience and decision making capacities as adults.   She has no problem ignoring the victims of human trafficking.   Her entire "religion" is based on exploiting child labor.  

That's how she got to be Attorney General of Florida.   Where she could ignore Jeffrey Epstein.   The billion dollar cult put her there to ignore their crimes.   And Trump has taken advantage of it.  

Trump's not a Christian either, you fuckin idiots.

Sunday, February 15, 2026

Friday, February 13, 2026

Ladies and Gentlemen: The Secretary of Health and Human Services


Measles cases in US top 900 as CDC confirms infections in 24 states

See the Vortex

Chronic Illness is the goal of this administration. 

Herpes viruses contribute to Alzheimer's.  





The undisputed champion

Trump, 79, Sparks Health Concerns With Bizarre Slurring

Everyone thinks this is cognitive.  It is not.  It is dental infection.  (so was Biden's)  The cognitive problems are a whole different mechanism.

I told you his left side was bad.   Look at that swelling.   He's clearly got calcification in both of the main salivary ducts.  When the one under his tongue is pinched it derails his "S" pronunciation.   It's possible he had this one probed and dilated, or maybe he's got a bad tooth.

This event was fascinating because then the upper duct flinched and set off his phrenic nerve.   That weird phrase in the middle is Tourettes,  his mouth adjusting the salivary ducts and motor nerves with vocalization.  It sounds like something he WASN'T supposed to say, a diabolical hallmark of tics.

He clearly is used to this, he recovered without stopping.

Yeah, Me too.