The incidence of PD is much lower that the other diseases I have mentioned. I think there are two reasons:
It is a bit more complicated to produce.
Because of that it manifests later in life and people die of other complications of
infection like heart attacks instead.
Current research shows there are multiple failure sites in the substantia nigra, and several routes of transmission.
My observations and research indicate that rather than a combination of 2 microbes, there are (at least) three: P. gingivalis (gum disease), Candida albicans (yeast) and Helicobacter pylori (stomach ulcers). These three each enhance the others, and form a really complicated web to untangle.
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Candida and PG form a cooperative biofilm at the gumline. The infections are both milder, but are able to persist longer.
H. pylori and PG- co-incubation in the oral cavity enhances Porphyromonas gingivalis virulence.
Candida and H. pylori -
form a virulent and resistant combination in the stomach.
H. pylori was also found to enter C. albicans yeast cells. Moving “bacterial-like bodies” in the vacuoles of the C. albicans yeast cells from the stomach were observed, and these were identified as H. pylori.
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How I think it works.
These people have chronic stomach ulcers. Their oral microbes go straight through the holes and get into their bloodstream and body cavity. The gluten, germs and alcohol make the intestines permeable too.
PG gingipains can apparently travel to the substantia nigra. They are found in the neurons there. They seem to cause the damage to Alpha Synuclein and clog up the cells.
Candida produces melanin while infecting it’s host. This melanin also escapes the stomach. That
stimulates the creation of anti-melanin antibodies. I’m quite convinced that similar to Multiple Sclerosis, some people’s HLA
genes code for fungal anti-melanin antibodies that cross react with human
melanin. Their antibodies then attack
the melanin in the substantia nigra too.
Cryptococcus infection of the nasal sinuses rapidly causes Parkinsonian symptoms. PG enhanced Candida in the nose may produce the same efffect more slowly. Other fungal species produce melanin as well.
These are the foods I think are the most common sources of mold for these people: bread, beer, wine, nuts, honey. Americans seem to eat large amounts of peanut butter too. (Almonds are not susceptible to this fungus. If you have ulcers, please switch to almond butter.)
This is what is in their medicine cabinets and car consoles: antacid stomach medication. I haven’t yet looked to see if that creates
another feedback loop….
My father was an Air Force fighter jet pilot. When those were new. He was obsessed with airplanes. He would fuse his neural systems with his machine. He had full body twitch control at the sound barrier. He joined the National Guard after his tours of duty so he could keep flying really fast.
He was a typical pilot- very precise. He was a typical soldier- wanted to follow the rules. He was the most logical and disciplined person I have ever met. He believed that anything could be overcome with willpower. (I was a complete mystery to him. So unpredictable.)
He told me about his symptoms a decade after he had been diagnosed. I begged him for years to give up the beer and bread. I asked him one last time as we took away his car keys. He shoved a honey covered biscuit into his face like a five year old. It was the most heartbreaking moment of my life.
Long before he died, he couldn’t walk or get a spoon into his mouth. He lost the thing that he was the very best at, and loved the most- his self-control.
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Ability of Helicobacter pylori to internalize into Candida
Anti-melanin
antibodies are increased in sera in Parkinson's disease
Synthesis of Melanin Pigment by Candida albicans In Vitro and during Infection
Fungal melanin-induced metabolic reprogramming in macrophages is crucial for inflammation
Parkinson's Disease: A
Comprehensive Analysis of Fungi and Bacteria in Brain Tissue
