Under your Nose

Schizophrenia onset linked to elevated neural links

In its chronic stage, schizophrenia is typically marked by a dearth of links between brain cells in the prefrontal cortex, the region of the brain responsible for higher-order thinking. However, a new study by Yale and Chinese researchers shows that the onset of the disease—usually in the early 20s—is marked by an abnormal spike in neural connections.
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Anticevic cautioned it is unclear whether the excess of connectivity causes symptoms of schizophrenia or whether this neural "signature" is the result of some other process, such as fever is a response to infection. If further research establishes this link then individuals during early-stage schizophrenia might benefit from drugs that can minimize the abnormal spike in neural communication, notes Anticevic.

Yes, such as a fever is a response to infection...  kind of exactly...

Infection raises cortisol levels.
Which raises dopamine levels.
Which increases prefrontal activity and connectivity. 
Until the chronic endotoxemia kills them.

It's really confusing when your brain is fried and still runs on overdrive...