The scientists explained that beta-lactam antibiotics kill normal staph bacteria by inactivating their cell-wall-making enzymes. But one of these enzymes, PBP2A, which is induced when MRSA is exposed to beta-lactam antibiotics, is not rendered inactive by the antibiotics. In fact, PBP2A allows the superbug to continue making its cell wall. Further, the cell wall's structure differs from that of normal staph, and not in a good way. "This altered cell wall induces a powerful inflammatory response," said the study's co-senior author, David Underhill, PhD, associate director of the Division of Immunology Research in the Cedars-Sinai Department of Biomedical Sciences and the Janet and William Wetsman Family Chair in Inflammatory Bowel Disease. "In mice infected with MRSA, induction of PBP2A with methicillin led to more inflammation and pathology."Yeah, beta-lactam antibiotics are flat out evil. They seem to make everything worse.
In other words, the mice became sicker.
And not to put too fine a point on this.... but my doctor gave me Keflex to prevent MRSA.
Prophylactic use is against protocol, and this shows clearly that it could not have helped.
And people tell me I have a bad attitude about doctors...
