Wednesday, February 3, 2016

Correlation Games

Diabetes discovery could lead to more effective drugs
The formation of type 2 diabetes is directly related to how our muscles convert sugar, a landmark new study has found.
The work, published in Molecular Metabolism, is the first strong evidence that when muscles fail to convert glucose into a substance called glycogen, it leads to the hallmarks of type 2 diabetes.  They hope the research will lead to development of a drug to that could convert glucose into glycogen when muscle metabolism fails.
My turn:

Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system.
We show that injection of orexin-A into the ventromedial hypothalamus of mice or rats increased glucose uptake and promoted insulin-induced glucose uptake and glycogen synthesis in skeletal muscle, but not in white adipose tissue...
And guess what not only raises blood glucose but also lowers orexin production?
Sugar.  

Maybe we don't actually need those drugs to solve this problem.  Just sayin.