Free your mind

New hope for Alzheimer’s: lithium supplement reverses memory loss in mice

The clues added up. The authors found that lithium levels were lower in parts of the human brain affected by Alzheimer’s disease than in unaffected regions. The team also discovered that in people with mild cognitive impairment, a precursor to Alzheimer’s, brain lithium is tied up in amyloid plaques, leaving less available for essential brain functions. This lithium withdrawal “became more severe as the disease progressed”, says Yankner.

Isn't that interesting, a product of the brain's immune response- Beta Amyloid- actually binds to and sequesters an antimicrobial molecule.   Go figure.

This is not the cause of the problem, it is an effect.

Antibacterial Evaluation of Lithium-Loaded Nanofibrous Poly(L-Lactic Acid) Membranes Fabricated via an Electrospinning Strategy

Adhesion of P.gingivalis on Li-PLLA membranes was significantly lower than adhesion on pure PLLA membranes, particularly with regard to the 10%Li and 15%Li membranes. Significant antibacterial activity of Li-PLLA were also observed against according to the inhibition zone test.

Lithium carbonate accelerates the healing of apical periodontitis

Lithium carbonate accelerates the healing of periapical periodontitis

Lithiated porous silicon nanowires stimulate periodontal regeneration

Hey Boys. Yoo Hoo.

Not just diabetes: How slightly high blood sugar wrecks men’s sexual health

Declines in sperm movement, erectile function may be linked to elevated blood sugar.

Actually, both are linked to P. gingivalis.

Big Red Flag Here

Complex Medical Conditions Drive Children’s Mental Health Problems  

The odds of a mental health diagnosis in children with chronic medical conditions increased stepwise based on the severity of their illness, according to data from nearly 3 million children...

In a retrospective study, the researchers examined data from children aged 5-17 years with at least 11 months of continuous Medicaid enrollment in 2022 based on the Merative MarketScan Medicaid Database. The study population included 2.9 million children, categorized into noncomplex nonchronic (NCNC) conditions, noncomplex chronic (NCC) conditions, and complex chronic conditions (CCC).

Overall, 310,000 (10.6%) of the children had a mental health diagnosis, and the rates increased stepwise with increasing severity and chronicity of disease: 7.6%, 16.0%, and 20% for the NCNC, NCC, and CCC groups, respectively. The most common mental health diagnoses were trauma/stressor disorders, anxiety disorders, and depressive disorders, accounting for 5.3%, 4.6%, and 4.3%, respectively.

Yeah, this doesn't get lower as we age...

Unfit for Duty

More Presidential Narcolepsy

HT Jeff Tiedrich

Yo Dentists

When I Was 7, I Stopped Feeling Any Kind Of Pain. Years Later, I Finally Learned Why.

"I got my wisdom teeth pulled without anesthesia or laughing gas ... I barely felt a thing." 

Another case of Pyschological  Bullshit.  I guarantee this woman has systemic PG.

Oh Really

Manhattan shooting suspect claimed to have CTE, mentioned NFL in note: 'Study my brain'

Those studies have already been done-  this is not a mystery.

Repetitive injury induces phenotypes associated with Alzheimer’s disease by reactivating HSV-1 in a human brain tissue model

Fear thy Neighbor

This it the best hypothesis I have learned in a long time:

The Uncanny Valley Theory of Human Evolution  by NorthO2

It's a 13 minute video.   He's a very good science explainer...

Holy Frankenfuck

FDA Names Former Pharmaceutical Executive To Oversee U.S. Drug Program

 RFK Jr. Is Letting AI Help Run the FDA. There’s Just One Problem

The FDA’s new AI assistant is straight-up inventing data.

That is a medical librarian's nightmare.   Holy mindfuck.     

 Trump Fails Basic Math Problem Trying to Brag About Drug Prices

According to Donald Trump, prescription drugs will now cost negative money.

“This is something that nobody else can do,” Trump said during a reception with members of Congress Tuesday night. “We’re gonna get the drug prices down. Not 30 or 40 percent, which would be great, not 50 or 60, no. We’re gonna get ’em down 1,000 percent, 600 percent, 500 percent, 1,500 percent.”

He bragged that he could use a “certain talent” to reach “numbers not even thought to be achievable.” 

Not even in my most delirious and demented moments did I say shit like that.   

Not being able to manipulate or remember numbers is a sign of serious ear problems.   I lost all my math ability after breaking four molars during sepsis.

His ears are ringing.  His astrocytes are fossilized.

He is desperately sick.

What I See

 Donald Trump has a Neck Pussy.  NSFW    -Cliff Cash Comedy

I am definitely not the only one who sees this.    

But the sad fact is, being overweight isn't the problem. 

And dieting won't solve it.

Fascinating

I don't know why I never looked at him before.    Serious dental problems here.   It was hard to find pictures.    He scrubbed his childhood ones and closes his mouth for pictures.   Kind of like Putin.

He had no canine teeth.   And horrific gums.

I'm guessing they once were impacted like this, or worse grew on the inside.  He also had one of those incisors capped. 

Yeah, pinching these nerves tends to cause obsession and cruelty.  I don't know why, but it does.   Been there, done that.

Stolen from a protest sign

ELECT A RAPIST-

EXPECT TO GET FUCKED.

For the Record

The pumpkin head has heart failure.     And he knows it.

He also has dementia.  And he knows that too.

These are classic symptoms of P.gingivalis.

He surely infected all those girls and women he "didn't assault".

Dear MAHA

(bumping to the top)

You are right, the medical system is ineffective.  But ignoring infectious disease is the absolute wrong strategy for public health care. Decades of searching for non-communicable causes (diet, toxins, stress, etc.) is the reason you have so many chronic illnesses.  Feel free to blame Freud and Psychs, I agree with you they're useless.

Unfortunately, you're also trashing the most important part of medicine:  Infection surveillance and prevention.  

There are a lot of problematic germs circulating right now, but let me tell you about one you probably already have… Porphyromonas gingivalis is a bacterium that causes chronic gum disease. 

• It is invisible and painless.  It disables pain receptors.   You can't see or feel it.
• It penetrates your oral cells in about fifteen minutes.  It then moves into your nerves and blood.
• It creates toxic molecules that travel around your body and cut your collagen and hemoglobin apart.  They also destroy GLP-1 and cause Diabetes.
• It get swallowed into your digestive tract.  It interacts with alcohol to trigger many Cancers.
• It gets inhaled into your lungs and promotes pulmonary diseases and cancer.
• It combines with Strep mutans to create Atherosclerosis.
• It combines with the Herpes 1 virus and other microbes in the brain to cause Alzheimer’s.
• It interacts with Epstein-Barr virus to create Multiple Sclerosis pathology.
• It probably interacts with H. pylori and Candida albicans to create stomach ulcers and Parkinson’s.
• IT IS ALSO TRANSMITTED SEXUALLY…
• It lives in the genitals and causes erectile dysfunction and eventually prostate cancer.
• It lives in the uterine area and placenta and causes pregnancy problems.    
• It is strongly associated with AUTISM.  Not only via infection of the mother during pregnancy, but familial transmission after birth.
• Almost everyone has it.   (this includes All humans throughout history.)
• It is resistant to most antibiotics.  It disables common antiseptics.
• There are already effective vaccines for mice.

RFKJr  IS COMPLETELY WRONG.   HUMAN VACCINES ARE EXACTLY WHAT IS NEEDED.  

The cause of human suffering is microbes.  It always has been.

Here’s a good review article:   

Porphyromonas gingivalis and Its Systemic Impact: Current Status

Here’s my thoughts on the topic:

Auntie Zombie Explains Insanity 

Sigh

 Barbie launches first doll with type 1 diabetes

See the Truth

 

Insert Curse Words Here

 “We are witnessing a true reversal of ocean circulation in the Southern Hemisphere—something we’ve never seen before,” explains Antonio Turiel, ICM-CSIC researcher and co-author of the study. “While the world is debating the potential collapse of the AMOC in the North Atlantic, we’re seeing that the SMOC is not just weakening, but has reversed. This could have unprecedented global climate impacts.”

Hear His Habenula Howl

Trump said: “They wouldn’t vote only because they hate Trump, but I hate them, too, you know that?”

“I really do. I hate them,” Trump repeated. “I cannot stand them, because I really believe they hate our country, if you want to know the truth.”

Very Sick People

Literally lose their ability to feel.   It's a symptom.

See the pathology

Got Milk?

Study Finds Water Isn't the Best Drink for Hydration

I've been saying this for a decade...

Never Forget

Fuck Donald Trump and Fuck You if you voted for him.

Move Fast. Kill People.

Tesla blows past stopped school bus and hits kid-sized dummies in Full Self-Driving tests

I do not understand why anyone would want a full self-driving vehicle.  Or even want them on the road.   Or how it can be legal.   It's insane in so many ways.

There is a never ending supply of irresponsible people out there...

Local governments approved this.  Has there ever been a referendum?   I want to know what voters think.

This and That

99-Million-Year-Old Amber Fossils Mark The Oldest Known Example Of “Zombie Fungus” Infection

Nicotine Gum Gave Me My Brain Back

Scientists discover unknown organelle inside our cells

Progesterone affects periodontitis in perimenopausal women and in an experimental rat model

Cold sore virus hijacks human genome in 3D--and scientists found its weak spot

Cold sore-causing HSV-1 doesn't just hijack cells it reconfigures the entire architecture of our DNA to aid its invasion. 

 'Best place to have herpes': New Zealand advert wins top prize

The campaign aimed to destigmatise herpes via a faux tourism advertisement video.

Statins may reduce risk of death by 39% for patients with life-threatening sepsis, large study finds

That's because they are antimicrobial...

Simple Math

 Republicans want Americans to get sick and die.   Because profit.

Hey Alpha Boys

Here's an infection you might want to avoid while you're cosplaying mountain men:

‘Explosive increase’ of ticks that cause meat allergy in US due to climate crisis

The ticks are known to be unusually aggressive and can provoke an allergy in bitten people whereby they cannot eat red meat without enduring a severe reaction, such as breaking out in hives and even the risk of heart attacks. The condition, known as alpha-gal syndrome, has proliferated from just a few dozen known cases in 2009 to as many as 450,000 now.

One of my friends in Seattle had this.   It will fuck up your life real good.  No steaks. No hamburgers. The only meat she could eat was lamb.  That is expensive and hard to find.

My senator, on point