Wednesday, July 18, 2012

Back to the Future

Obesity pill Qsymia gains FDA approval

Qsymia is the new name for another drug Qnexa, that wasn't approved for safety reasons.  Very clever.
Anyhow, it is a combination of Phentermine and Topiramate.   Phentermine is a methylated amphetamine, and Topiramate increases insulin sensitivity in fat cells.

(For the record-  Phentermine and Topiramate are both generic drugs now.   The only reason this pill exists is to provide the financial benefit of patent protection.)

I really like Phentermine in small doses.   It's an anorectic- reduces hunger- and the lowered food intake really did help my symptoms more than just losing weight.   It does increase anxiety and pain though.   And it also promotes dry mouth and gum disease which is the real reason it causes heart problems and if doctors realized this and gave oral care advice it might be the perfect narcolepsy drug, but I digress...

Topiramate increases insulin sensitivity.    If you are  hyperinsulinemic this is the EXACT OPPOSITE thing you want.   It is good for insulin deficient or resistant diabetics, but for narcoleptics will probably  cancel out the metabolic enhancing properties of the other drug.

But don't worry.   When it doesn't work for you, they will get approved to upgrade you to surgery.
SSDD.