Monday, May 25, 2015

Yo Dr. Mignot

Serum cytokine levels in Kleine-Levin Syndrome 
We did not observe any changes in serum cytokine levels during KLS episodes compared to between episodes. In a small cohort of asymptomatic KLS patients and age and gender matched healthy controls (n=8/group), all collected and processed at the same day, asymptomatic KLS patients had significantly higher levels of serum sVCAM1 compared to healthy controls.
These data suggest that KLS episodes are not accompanied by an abnormal systemic immune reaction.
So.. you are paying attention.   Huh.
I'm glad you put this on record.   Yeah, I like that a lot.
It will make a nice companion for that flu study you retracted.

You have got this so backwards.   You were looking for a Normal immune response not an "abnormal" one...
Don't you think that if they showed the expected signs of sepsis someone would have noticed-  like maybe centuries before you became a doctor?

You need to look for a strain of strep that  produces aberrant adhesin molecules.   They don't trigger a cytokine storm.  Oh, and I suggest some titers for streptolysin and pneumolysin, too.
That would probably explain all of this.

Actually, we don't need your input or hasty conclusions anymore.
Karolinska is on this already.
Please feel free to go off and exploit someone else's misery...