From Lydia. Nice finds.
Adolescent gamma-hydroxybutyric acid exposure decreases cortical NMDA receptor and impairs spatial learning
Adolescent gamma-hydroxybutyric acid exposure decreases cortical NMDA receptor and impairs spatial learning
Together, these data indicate that GHB exposure in adolescent rats negatively impacts spatial learning and this is associated with altered regulation of cortical NMDA receptor.
These data indicate that GHB exposure in adolescent female rats has a negative impact on spatial learning and memory.
Neurotoxic effects induced by gammahydroxybutyric acid (GHB) in male rats
Stereological quantification showed that this drug produces a drastic neuronal loss in the hippocampal region and in the prefrontal cortex, two areas clearly involved in cognitive and neurological functions. ... The results show for the first time that the repeated administration of GHB, especially at very low doses, produces neurotoxic effects. This is very relevant because its abuse, especially by young persons, could produce considerable neurological alterations after prolonged abuse.
