Geez Louise

Alzheimer’s drug found to cause harm to mouse brain cells

Alzheimer’s plaques form when protein pieces called beta amyloid clump together. Busche and his colleagues previously discovered that beta amyloid proteins can cause neurons to become hyperactive. They suggest that when the antibodies break up the plaques, it somehow aggravates this effect, making it worse than if the plaques remained intact.
In the wake of multiple failures trying to treat people with advanced Alzheimer’s disease, drug developers have switched to trying to detect and treat disease earlier.
So Busche and his team also studied the effect of the drug in mice with early-stage Alzheimer’s. Even in these mice, which had no plaques in their brains, neurons became hyperactive and symptoms of the disease worsened.

Mercy, mercy, mercy.