I am having a real hard time thinking about this.
I have been telling my doctors and dentists my brain problems come from my effin teeth for a decade.
They have rolled their eyes at me.
And taken my money anyway.
The only reason I am alive is because I didn't listen to them.
I can't look at much research because I am tired of screaming right now.
I am very exhausted from living in this mirror.
Anyway, here's the one search I could manage.
Orthodontic brackets increase levels of porphyromonas gingivalis.
(and the tissue wounds that transfer bacteria to the brain...)
Yeah, I had braces for nine years before I was 21.
I'm pretty sure that living in an Alzheimer's facility, eating pancakes, and not remembering to brush your teeth does the same thing...
Wednesday, March 27, 2019
We may finally know what causes Alzheimer’s – and how to stop it
Multiple teams have been researching Porphyromonas gingivalis, the main bacterium involved in gum disease, which is a known risk factor for Alzheimer’s. So far, teams have found that P. gingivalis invades and inflames brain regions affected by Alzheimer’s; that gum infections can worsen symptoms in mice genetically engineered to have Alzheimer’s; and that it can cause Alzheimer’s-like brain inflammation, neural damage and amyloid plaques in healthy mice.
“When science converges from multiple independent laboratories like this, it is very compelling,” says Casey Lynch of Cortexyme, a pharmaceutical firm in San Francisco.
Now researchers from Cortexyme and several universities have reported finding the two toxic enzymes that P. gingivalis uses to feed on human tissue in 99 and 96 per cent of 54 human Alzheimer’s brain samples taken from the hippocampus – a brain area important for memory (Science Advances, doi.org/gftvdt). These protein-degrading enzymes are called gingipains, and they were found in higher levels in brain tissue that also had more tau fragments and thus more cognitive decline.
The team also found genetic material from P. gingivalis in the cerebral cortex – a region involved in conceptual thinking – in all three Alzheimer’s brains they looked for it in.
“This is the first report showing P. gingivalis DNA in human brains, and the associated gingipains co-localising with plaques,” says Sim Singhrao at the University of Central Lancashire, UK, who wasn’t involved in the study. Her team has previously found that P. gingivalis actively invades the brains of mice with gum infections.