Monday, March 9, 2020

Another good article

People ‘shed’ high levels of coronavirus, study finds, but most are likely not infectious after recovery begins
The researchers found very high levels of virus emitted from the throat of patients from the earliest point in their illness —when people are generally still going about their daily routines. Viral shedding dropped after day 5 in all but two of the patients, who had more serious illness. The two, who developed early signs of pneumonia, continued to shed high levels of virus from the throat until about day 10 or 11.
This pattern of virus shedding is a marked departure from what was seen with the SARS coronavirus, which ignited an outbreak in 2002-2003. With that disease, peak shedding of virus occurred later, when the virus had moved into the deep lungs.
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 Osterholm said the data in the paper confirm what the spread of the disease has been signaling - “early and potentially highly efficient transmission of the virus occurs before clinical symptoms or in conjunction with the very first mild symptoms.”
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The researchers monitored the viral shedding of nine people infected with the virus. In addition to tests looking for fragments of the virus’s RNA, they also tried to grow viruses from sputum, blood, urine, and stool samples taken from the patients. The latter type of testing -trying to grow viruses -is critical in the quest to determine how people infect one another and how long an infected person poses a risk to others.
Importantly, the scientists could not grow viruses from throat swabs or sputum specimens after day 8 of illness from people who had mild infections.
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The German researchers found high levels of viral fragments in 13 stool samples from four patients in their study, but they were unable to grow virus from any of them...“
Virus could not be grown from blood or urine samples taken from the patients, the authors reported...

...adding that their findings suggest measures to try to stop spread of the virus should focus on respiratory tract transmission — protecting others from the coughs and sneezes of people infected with the virus.
It looks very much like you want to keep in in your nose and not let it make a home your lungs. 
Antibodies kick in at about day 8.