Retinal neurons provide insight into schizophrenia disease mechanisms
In a previous study, researchers found alterations in the retina of schizophrenia patients that became more severe with increased genetic risk. Accordingly, the researchers suspected that retinal alterations are not only a consequence of common comorbidities like obesity or diabetes, but might be caused by schizophrenia-driven diseases mechanisms directly.
In addition to schizophrenia, retinal alterations have been observed in patients with bipolar disorder, depression, multiple sclerosis (MS), Alzheimer's disease, Parkinson's disease and stroke.
PG is documented to invade the retina and gingipains are found there too.
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Study reveals immune system changes linked to schizophrenia and treatment resistance
Specifically, the researchers found that the ratio of CD4 to CD8 T cells was much higher, while the levels of mucosal-associated invariant T (MAIT) cells were much lower in individuals with schizophrenia, especially in those with greater treatment resistance.
Reduced CD8+ peripheral blood T lymphocytes are found in rapidly progressive periodontitis
