Protein Kinase C (PKC) is a group of enzymes that act as catalysts for a host of cellular functions, among which are cancer-relevant activities, such as cell survival, proliferation, apoptosis, and migration. The discovery that they are receptors for tumor-producing phorbol esters, plant-derived compounds that bind to and activate PKC, created a dogma that activation of PKCs by phorbol esters promoted carcinogen-induced tumorigenesis.That one will go in the chapter on man's ability to increasingly intricately measure irrelevant things. With serum cholesterol. And maternal attachment.
"For three decades, researchers have sought to find new cancer therapies based on the idea that inhibiting or blocking PKC signals would hinder or halt tumor development," said Alexandra Newton, PhD, professor of pharmacology and the study's principal investigator, "but PKCs have remained an elusive chemotherapeutic target." The reason, suggest Newton and colleagues, is that contrary to conventional wisdom, PKCs do not promote cancer progression; rather, they act to suppress tumor growth.
Viruses may play unexpected role in inflammatory bowel diseases
I don't know about you, but I do not find that surprising.
Regular marijuana use may not be so bad for your lungs
Smoking a joint every day for 20 years was not associated with negative changes in exhalation strength.So have a nice weekend.
