The more I look, the less I see Free Will.
All gram negative bacteria,and most other microbes in the blood lower orexin levels. Orexin is a neurotransmitter that controls energy levels. Orexin stimulates dopamine production , so motivation is decreased as well.
Animals with low orexin levels are lethargic, and eat less but weigh more than controls.
Almost all infections cause astrocytes in the brain to decrease their functioning, and the neurons to increase production of beta amyloid, slowing down thinking and reducing attention and memory.
P. gingivalis in specific:
The gingipains cleave hemoglobin. This lowers available oxygen to the cells.
And GLP-1. Lowering your ability to metabolize glucose.
It disables insulin receptors. Raising your insulin resistance.
And mitochondria. They produce reactive oxygen instead of ATP.
That's just one microbe. It fucks up metabolism on many levels. It also interacts with many others in many known and unknown ways...
Now- Everyone-
You must stop telling us to eat less and move more.
Stop telling yourselves and everyone that laziness and overeating make us fat.
Stop giving us drugs and activities that don't solve the problem.
This is not an "Eating Disorder" - it is CHRONIC METABOLIC DYSFUNCTION caused by missed diagnoses...
